Pharmacogenomics Methods and Protocols 2nd Edition by Rosane Charlab, Lei Zhang, Federico Innocenti ISBN 1627034358 9781627034357

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ISBN 10: 1627034358 
ISBN 13: 9781627034357
Author: Rosane Charlab, Lei Zhang, Federico Innocenti

Understanding an individual’s genetic makeup is the key to creating personalized drugs with greater efficacy and safety, and pharmacogenomics aims to study the complex genetic basis of inter-patient variability in response to drug therapy.  Based upon the success of its first edition, the second edition of Pharmacogenomics: Methods And Protocols aims to continue providing readers with high-quality content on the most innovative and commonly adopted technologies in the field of pharmacogenomics as presented by experts in the field.  Broken into several sections, this detailed volume examines techniques for interrogating variation in human genes and genomes, functional assessment of genetic variation, both in vitro and in vivo, as well as tools for translation and implementation of pharmacogenetic markers. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to the respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Pharmacogenomics Methods and Protocols 2nd Table of contents:

Part I: Introduction to Pharmacogenomics

1. Pharmacogenomics: Historical Perspective and Current Status – Rosane Charlab and Lei Zhang

Part II: Techniques for Interrogating Variation in Human Genes and Genomes

2. Denaturing High-Performance Liquid Chromatography for Mutation Detection and Genotyping – Donna Lee Fackenthal, Pei Xian Chen, Ted Howe, and Soma Das

3. Clinical SNP Detection by the SmartAmp Method – Toshihisa Ishikawa and Yoshihide Hayashizaki

4. MALDI-TOF Mass Spectrometry – Dirk van den Boom, Matthias Wjst, and Robin Everts

5. Methods to Examine the Impact of Nonsynonymous SNPs on Protein Degradation and Function of Human ABC Transporter – Toshihisa Ishikawa, Kanako Wakabayashi-Nakao, Hiroshi Nakagawa

6. In Vitro Identification of Cytochrome P450 Enzymes Responsible for Drug Metabolism – Zhengyin Yan and Gary W. Caldwell

Part III: Functional Assessment of Genetic Variation

7. Functional Analysis of Gene Variation – Hideki Jinno, Nobumitsu Hanioka, Toshiko Tanaka-Kagawa, Yoshiro Saito, Jun-ichi Sawada, Shogo Ozawa

8. Snapshot of the Allele-Specific Variation in Human Gene Expression – Hai Yan

9. Genome-Wide Analysis of Allele-Specific Gene Expression Using Oligo Microarrays – Maxwell P. Imle and Peter Imle

10. Single-Nucleotide Polymorphism Genotyping in DNA Pools – Ian Craig, Emma Meaburn, Lee Butcher, Linzy Hill, Robert Plomin

11. TaqMan Genotyping of Insertion/Deletion Polymorphisms – Renato Robledo, William R. Beggs, Patrick K. Bender

Part IV: Management of Pharmacogenomic Information

12. PharmGKB – Caroline F. Thorn, Teri E. Klein, Russ B. Altman

13. Systems for the Management of Pharmacogenomic Information – Alexander Sturn, Michael Maurer, Robert Molidor, Zlatko Trajanoski

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Tags: Rosane Charlab, Lei Zhang, Federico Innocenti, Pharmacogenomics Methods