Sale!

Introduction to Enzyme and Coenzyme Chemistry 3rd Edition by TDH Bugg ISBN 1119995957 9781119995951

Original price was: $50.00.Current price is: $35.00.

Introduction to Enzyme and Coenzyme Chemistry Third Edition T. D. H. Bugg(Auth.) Digital Instant Download

Author(s): T. D. H. Bugg(auth.)
ISBN(s): 9781119995951, 1119995957
File Details: PDF, 4.11 MB
Year: 2012
Language: english
SKU: EB-4306778 Category: Tag:

Introduction to Enzyme and Coenzyme Chemistry 3rd Edition by TDH Bugg – Ebook PDF Instant Download/Delivery: 1119995957, 9781119995951
Full download Introduction to Enzyme and Coenzyme Chemistry 3rd Edition after payment

Product details:

ISBN 10: 1119995957 
ISBN 13: 9781119995951
Author: TDH Bugg

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Introduction to Enzyme and Coenzyme Chemistry 3rd Table of contents:

Chapter 1: From Jack Beans to Designer Genes
1.1 Introduction
1.2 The discovery of enzymes
1.3 The discovery of coenzymes
1.4 The commercial importance of enzymes in biosynthesis and biotechnology
1.5 The importance of enzymes as targets for drug discovery

Chapter 2: All Enzymes Are Proteins
2.1 Introduction
2.2 The structures of the L-α-amino acids
2.3 The primary structure of polypeptides
2.4 Alignment of amino acid sequences
2.5 Secondary structures found in proteins
2.6 The folded tertiary structure of proteins
2.7 Enzyme structure and function
2.8 Metallo-enzymes
2.9 Membrane-associated enzymes
2.10 Glycoproteins

Chapter 3: Enzymes Are Wonderful Catalysts
3.1 Introduction
3.2 A thermodynamic model of catalysis
3.3 Proximity effects
3.4 The importance of transition state stabilisation
3.5 Acid/base catalysis in enzymatic reactions
3.6 Nucleophilic catalysis in enzymatic reactions
3.7 The use of strain energy in enzyme catalysis
3.8 Desolvation of substrate and active site nucleophiles
3.9 Catalytic perfection
3.10 The involvement of protein dynamics in enzyme catalysis

Chapter 4: Methods for Studying Enzymatic Reactions
4.1 Introduction
4.2 Enzyme purification
4.3 Enzyme kinetics
4.4 The stereochemical course of an enzymatic reaction
4.5 The existence of intermediates in enzymatic reactions
4.6 Analysis of transition states in enzymatic reactions
4.7 Determination of active site catalytic groups

Chapter 5: Hydrolytic and Group Transfer Enzymes
5.1 Introduction
5.2 The peptidases
CASE STUDY: HIV-1 protease
5.3 Esterases and lipases
5.4 Acyl transfer reactions in biosynthesis (coenzyme A)
5.5 Enzymatic phosphoryl transfer reactions
5.6 Adenosine 5′-triphosphate (ATP)
5.7 Enzymatic glycosyl transfer reactions
5.8 Methyl group transfer: use of S-adenosyl methionine and tetrahydrofolate coenzymes for one-carbon transfers

Chapter 6: Enzymatic Redox Chemistry
6.1 Introduction
6.2 Nicotinamide adenine dinucleotide-dependent dehydrogenases
6.3 Flavin-dependent dehydrogenases and oxidases
6.4 Flavin-dependent mono-oxygenases
6.5 CASE STUDY: Glutathione and trypanothione reductases
6.6 Deazaflavins and pterins
6.7 Iron-sulphur clusters
6.8 Metal-dependent mono-oxygenases
6.9 α-Ketoglutarate-dependent dioxygenases
6.10 Non-heme iron-dependent dioxygenases

Chapter 7: Enzymatic Carbon–Carbon Bond Formation
7.1 Introduction
Carbon–carbon bond formation via carbanion equivalents
7.2 Aldolases
CASE STUDY: Fructose 1,6-bisphosphate aldolase
7.3 Claisen enzymes
7.4 Assembly of fatty acids and polyketides
7.5 Carboxylases: Use of biotin
7.6 Ribulose bisphosphate carboxylase/oxygenase (Rubisco)
7.7 Vitamin K-dependent carboxylase
7.8 Thiamine pyrophosphate-dependent enzymes
Carbon–carbon bond formation via carbocation intermediates
7.9 Terpene cyclases
Carbon–carbon formation through radical intermediates
7.10 Phenolic radical couplings

Chapter 8: Enzymatic Addition/Elimination Reactions
8.1 Introduction
8.2 Hydratases and dehydratases
8.3 Ammonia lyases
8.4 Elimination of phosphate and pyrophosphate
8.5 CASE STUDY: 5-Enolpyruvyl shikimate 3-phosphate (EPSP) synthase

Chapter 9: Enzymatic Transformations of Amino Acids
9.1 Introduction
9.2 Pyridoxal 5′-phosphate-dependent reactions at the α-position
9.3 CASE STUDY: Aspartate aminotransferase
9.4 Reactions at the β- and γ-positions of amino acids
9.5 Serine hydroxymethyltransferase
9.6 N-Pyruvoyl-dependent amino acid decarboxylases
9.7 Imines and enamines in alkaloid biosynthesis

Chapter 10: Isomerases
10.1 Introduction
10.2 Cofactor-independent racemases and epimerases
10.3 Keto-enol tautomerases
10.4 Allylic isomerases
10.5 Case Study: Chorismate Mutase

Chapter 11: Radicals in Enzyme Catalysis
11.1 Introduction
11.2 Vitamin B12-dependent rearrangements
11.3 The involvement of protein radicals in enzyme catalysis
11.4 S-adenosyl-methionine-dependent radical reactions
11.5 Biotin synthase and sulphur insertion reactions
11.6 Radical chemistry in DNA repair enzymes
11.7 Oxidised amino acid cofactors and quinoproteins

Chapter 12: Non-Enzymatic Biological Catalysis
12.1 Introduction
12.2 Catalytic RNA
12.3 Catalytic antibodies
12.4 Synthetic enzyme models

People also search for Introduction to Enzyme and Coenzyme Chemistry 3rd:

introduction to enzyme and coenzyme chemistry
    
introduction to enzyme and coenzyme chemistry pdf
    
what are enzymes and coenzymes
    
define coenzyme in biochemistry
    
introduction to enzymes

Tags: TDH Bugg, Enzyme, Coenzyme Chemistry