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Tumor Immunology Molecularly Defined Antigens and Clinical Applications 1st Edition by Giorgio Parmiani, Michael T Lotze ISBN 9781134484997

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Tumor Immunology Molecularly Defined Antigens and Clinical Applications 1st Edition Giorgio Parmiani (Editor) Digital Instant Download

Author(s): Giorgio Parmiani (Editor); Michael T. Lotze (Editor)
ISBN(s): 9781134484997
Edition: 1
File Details: PDF, 9.67 MB
Year: 2002
Language: english
SKU: EB-12052228 Category: Tags: ,

Tumor Immunology Molecularly Defined Antigens and Clinical Applications 1st Edition by Giorgio Parmiani, Michael T Lotze – Ebook PDF Instant Download/Delivery: 9781134484997 
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ISBN 13: 9781134484997
Author: Giorgio Parmiani, Michael T Lotze

Recent advances in immunology and molecular biology have resulted in new therapeutic approaches being generated and implemented in cancer clinics. The discovery of new antigens, mechanisms of antigen presentation, and interplay of cells involved in anti-tumor immunity have made the clinical control of some cancers more plausible than previously tho

Tumor Immunology Molecularly Defined Antigens and Clinical Applications 1st Table of contents:

Chapter 1: Immune Recognition of Cancer – Tumor Antigens

  • Introduction

  • Tumor Antigens

    • Cancer-Testis Antigens

    • Differentiation Antigens

    • Widely Expressed Proteins

    • Tumor-Specific Antigens

    • Class II MHC-Restricted Tumor Antigens

  • Identification of Epitopes on Candidate Antigens

  • Modulation of T Cell Recognition

  • T Cell Receptor Analysis

  • Clinical Applications

  • References

Chapter 2: Processing and Presentation of Antigen for the Activation of Lymphocytes to Tumor Cells

  • Antigen Processing and Presentation: Critical Components

  • Endogenous Pathway

  • Exogenous Pathway

  • Antigen Presentation Molecules

    • MHC Class I

    • MHC Class II

    • MHC Class IB Molecules

    • CD1 Molecules

    • Heat Shock Proteins

  • Antigen Presentation by Professional Antigen Presenting Cells

    • Dendritic Cells

      • Antigen Uptake

      • Maturation and Migration

      • Activation of B and T Cells in Lymph Nodes

      • Cross-Priming

      • In Vitro Generation for Vaccination

    • Macrophages/Monocytes

    • B Lymphocytes

  • Non-Professional Antigen Presentation by Tumor Cells

  • Activation of CD8+ T Lymphocytes

  • Activation of CD4+ T Lymphocytes

  • Conclusions

  • Acknowledgments

  • References

Chapter 3: Cellular Recognition of Tumors by T and NK Cells

  • T Cell Recognition of Tumors

  • Role of T Cells in Antitumor Responses

  • CD4+ T Lymphocytes and Cancer

    • Direct vs. Indirect Antigen Presentation

    • Defects in Helper Arm of Immune Response

    • TH1 and TH2 Roles

    • CD4+ T Cells in Human Cancer

  • CD8+ T Lymphocytes and Cancer

    • CD8+ T Cells in Human Cancer

    • Failure of CD8+ Responses

    • Direct vs. Indirect Antigen Presentation

  • Role of Natural Killer (NK) Lymphocytes

    • Basis of NK Recognition

    • NKT Cells

  • Circulation and Homing of Tumor-Specific T and NK Cells

    • Role of Adhesion Molecules and Chemokines

  • References

Chapter 4: Humoral Recognition of Cancer

  • Mechanisms of B Cell Recognition and Effector Functions

  • Target Cancer Antigens

  • Antibody-Mediated Cancer Therapy

  • Cancer Vaccines to Enhance Antibody Responses

    • Vaccines Against Gangliosides

    • Other Antigens and Polyvalent Vaccines

  • Monoclonal Antibodies

    • Preparation

    • Therapeutic Applications

    • Diagnostic Applications

  • Conclusion

  • References

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Tags: Giorgio Parmiani, Michael T Lotze, Immunology Molecularly