Tissue Protective Cytokines Methods and Protocols 1st Edition by Pietro Ghezzi, Anthony Cerami ISBN 1627033084 9781627033084

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ISBN 10: 1627033084 
ISBN 13: 9781627033084
Author: Pietro Ghezzi, Anthony Cerami

While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines.

 In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs.

Tissue Protective Cytokines Methods and Protocols 1st Table of contents:

Erythropoietin and Engineered Innate Repair Activators
Michael Brines, Anthony Cerami
Pages 1-11
Epo and Non-hematopoietic Cells: What Do We Know?
Omolara O. Ogunshola, Anna Yu. Bogdanova
Pages 13-41
Tissue-Protective Cytokines: Structure and Evolution
Pietro Ghezzi, Darrell Conklin
Pages 43-58
The Regenerative Activity of Interleukin-6
Eithan Galun, Stefan Rose-John
Pages 59-77
Brain Ischemic Injury in Rodents: The Protective Effect of EPO
Annelise Letourneur, Edwige Petit, Simon Roussel, Omar Touzani, Myriam Bernaudin
Pages 79-101
Experimental Traumatic Spinal Cord Injury
Zübeyde Erbayraktar, Necati Gökmen, Osman Yılmaz, Serhat Erbayraktar
Pages 103-112
Erythropoietin as a Neuroprotectant for Neonatal Brain Injury: Animal Models
Christopher M. Traudt, Sandra E. Juul
Pages 113-126
Evaluating Effects of EPO in Rodent Behavioral Assays Related to Depression
Catharine H. Duman, Samuel S. Newton
Pages 127-140
Erythropoietin and Cytoprotective Cytokines in Experimental Traumatic Brain Injury
Samson Kumar Gaddam, Jovany Cruz, Claudia Robertson
Pages 141-162
Therapeutic Efficacy of Erythropoietin in Experimental Autoimmune Encephalomyelitis in Mice, a Model of Multiple Sclerosis
Ilaria Cervellini, Pietro Ghezzi, Manuela Mengozzi
Pages 163-173
Deciphering the Intracellular Signaling of Erythropoietin in Neuronal Cells
Murat Digicaylioglu
Pages 175-186
Assessment of Allodynia Relief by Tissue-Protective Molecules in a Rat Model of Nerve Injury-Induced Neuropathic Pain
Maarten Swartjes, Marieke Niesters, Albert Dahan
Pages 187-195
Intra-epidermal Nerve Fibers Density and Nociception in EPO-Treated Type 1 Diabetic Rats with Peripheral Neuropathy
Bianchi Roberto, Lombardi Raffaella, Porretta-Serapiglia Carla, Lauria Giuseppe
Pages 197-211
ARA290 in a Rat Model of Inflammatory Pain
Andrew Dilley
Pages 213-225
In Vivo Angiogenic Activity of Erythropoietin
Domenico Ribatti
Pages 227-235
Photoreceptor Degeneration in Mice: Adeno-Associated Viral Vector-Mediated Delivery of Erythropoietin
Pasqualina Colella, Alberto Auricchio
Pages 237-263
Myocardial Infarction: Cardioprotection by Erythropoietin
Mark I. Talan, Roberto Latini
Pages 265-302
Using Plethysmography to Determine Erythropoietin’s Impact on Neural Control of Ventilation
Tommy Seaborn, Max Gassmann, Jorge Soliz
Pages 303-314
Cerebral Malaria: Protection by Erythropoietin
Anne-Lise Bienvenu, Stephane Picot
Pages 315-324

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Tags: Pietro Ghezzi, Anthony Cerami, Tissue Protective, Cytokines Methods