Tinkering The Microevolution of Development Novartis Foundation Symposia 1st Edition by Novartis Foundation ISBN 0470319402 9780470319406

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ISBN 10: 0470319402 
ISBN 13: 9780470319406
Author: Novartis Foundation

Much recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan. Such microevolutionary events have been well studied on a population genetic level and from the perspective of adaptive phenotypic evolution, but their developmental mechanisms remain poorly studied.

This book explores both theoretical and practical issues of tinkering. It features a wide range of perspectives to address several fundamental questions. How does tinkering occur developmentally, and how is it manifested phenotypically? Are the developmental mechanisms by which tinkering occur different from those that underlie larger evolutionary changes? What are the developmental constraints on tinkering? And how do we test hypotheses about microevolutionary shifts in development from the fossil record?

With contributions from experts in a range of fields, this fascinating book makes exciting reading for anyone studying evolution, developmental biology or genetics.

Tinkering The Microevolution of Development Novartis Foundation Symposia 1st Table of contents:

Chapter 1: Conceptual Foundations of Developmental Evolution

• Evolutionary Developmental Biology (Evo-Devo)

• Microevolutionary Mechanisms

• Developmental Constraints and Plasticity

Chapter 2: Genetic Regulation and Development

• Gene Networks in Development

• Mutations and Phenotypic Variation

• Regulatory Evolution

Chapter 3: Morphogenesis and Pattern Formation

• Cellular and Molecular Mechanisms

• Evolution of Body Plans

• Case Studies in Morphological Change

Chapter 4: Evolution of Developmental Pathways

• Conserved vs. Divergent Pathways

• Modularity and Evolution

• Developmental Rewiring in Evolution

Chapter 5: Tinkering in Evolution

• Concept of “Evolutionary Tinkering”

• Examples from Plants and Animals

• Adaptive Significance

Chapter 6: Experimental Approaches

• Model Organisms and Systems

• Comparative Developmental Studies

• Techniques in Evo-Devo Research

Chapter 7: Implications for Evolutionary Theory

• Revisiting Classical Darwinism

• Microevolution and Macroevolution

• Future Directions in Evo-Devo

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Tags: Novartis Foundation, Microevolution, Novartis Foundation