The World of Nano Biomechanics Mechanical Imaging and Measurement by Atomic Force Microscopy 1st Edition by Atsushi Ikai ISBN 044452777X 9780444527776
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Product details:
ISBN 10: 044452777X
ISBN 13: 9780444527776
Author: Atsushi Ikai
The book describes the physical properties of such life supporting structures from the molecular level with a special emphasis on their designs based on the mechanical strength and flexibility, membrane and other biological nanostructures.
– Describes the basic mechanical features of proteins, DNA, cell membrane and other biological nanostructures
– Explains the basic concepts and mathematics of elementary mechanics needed to understand and perform experimental work
The World of Nano Biomechanics Mechanical Imaging and Measurement by Atomic Force Microscopy 1st Table of contents:
Chapter 1. Force in Biology
1.1 What are We Made of?
1.2 Human Body and Force
1.3 Biomechanics as the Big Brother
1.4 Molecular Basis for Structural Design
1.5 Soft versus Hard Materials
1.6 Biological and Biomimetic Structural Materials
1.7 Wear and Tear of Biological Structures
1.8 Thermodynamics and Mechanics in Nanometer Scale Biology
Bibliography
Chapter 2. Introduction to Basic Mechanics
2.1 Elastic and Plastic Deformation of Materials
2.2 Stress and Strain Relationship
2.3 Mechanical Breakdown of Materials
2.4 Viscoelasticity
2.5 Mechanical Moduli of Biological Materials
2.6 Fluid and Viscosity
2.7 Adhesion and Friction
2.8 Mechanically Controlled Systems
Bibliography
Chapter 3. Force and Force Measurement Apparatuses
3.1 Mechanical, Thermal, and Chemical Forces
3.2 Laser Trap
3.3 Atomic Force Microscope
3.4 Biomembrane Force Probe
3.5 Magnetic Beads
3.6 Gel Columns
3.7 Cantilever Force Sensors
3.8 Loading-rate Dependence
3.9 Force Clamp Method
3.10 Specific versus Nonspecific Forces
Bibliography
Chapter 4. Polymer Chain Mechanics
4.1 Polymers in Biological World
4.2 Polymer Chains
4.3 End-to-End Distance
4.4 Persistence Length
4.5 Polymers in Solution
4.6 Polymers on the Surface
4.7 Polymers as Biomimetic Materials
4.8 Polymer Pull-out
Bibliography
Chapter 5. Interaction Forces
5.1 Covalent versus Noncovalent Force
5.2 Basics of Electrostatic Interaction Force
5.3 Various Types of Noncovalent Forces
5.4 Application of External Force
5.5 Interaction Force Between Macromolecules
5.6 Water at the Interface
Bibliography
Chapter 6. Single-Molecular Interaction Forces
6.1 Ligand–receptor Interactions
6.2 Sugar–lectin Interactions
6.3 Antigen–antibody Interactions
6.4 GroEL and Unfolded-Protein Interactions
6.5 Lipid–protein Interactions
6.6 Anchoring Force of Proteins to the Membrane
6.7 Receptor Mapping
6.8 Protein Unanchoring and Identification
6.9 Membrane Breaking
Bibliography
Chapter 7. Single-molecule DNA and RNA Mechanics
7.1 Stretching of Double-stranded DNA
7.2 Hybridization and Mechanical Force
7.3 Chain Dynamics and Transition of DNA and RNA
7.4 DNA–protein Interaction
7.5 Prospect for Sequence Analysis
Bibliography
Chapter 8. Single-molecule Protein Mechanics
8.1 Protein-stretching Experiments
8.2 Intramolecular Cores
8.3 Stretching of Modular Proteins
8.4 Dynamic Stretching
8.5 Catch Bond
8.6 Protein-compression Experiments
8.7 Internal Mechanics of Protein Molecules
8.8 Mechanical Control of Protein Activity
8.9 Computer Simulation of Protein Deformation
Case Study: Carbonic Anhydrase II
Bibliography
Chapter 9. Motion in Nano-biology
9.1 Cell Movement and Structural Proteins
9.2 Muscle and Motor Proteins
9.3 Single-motor Measurements
9.4 Flagella for Bacterial Locomotion
9.5 Mycoplasma Gliding
9.6 Mechanics and Efficiency of Motor Proteins
Bibliography
Chapter 10. Cell Mechanics
10.1 Changes in Shape of Red Blood Cell
10.2 Membrane and Cytoskeleton
10.3 Association of Membrane Proteins with Cytoskeleton
10.4 Deformation of 2D Membrane
10.5 Helfrich Theory of Membrane Mechanics
10.6 Cytoplasm and Subcellular Structures
10.7 Indentation Experiment and the Use of Sneddon’s Formulae
10.8 Deformation Mechanics of a Thin Plate
Bibliography
Chapter 11. Manipulation at the Molecular Level
11.1 Prospects for Useful Applications of Nanomechanics
11.2 Cell Surgery
11.3 Chromosomal Surgery and Gene Manipulation
11.4 Tissue Surgery
11.5 Liposomal Technology
11.6 Drug Delivery
11.7 DNA and RNA Recovery from the Chromosome and the Cell
Bibliography
Chapter 12. Finite Element Analysis of Microscopic Biological Structures
12.1 Introduction
12.2 A Brief History of the Finite Element Method
12.3 The Finite Element Method
12.4 Application of the Finite Element Method to Microbiological Samples
12.5 Conclusion
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Tags: Atsushi Ikai, Nano Biomechanics, Mechanical Imaging, Atomic Force