The Road from Nanomedicine to Precision Medicine Part A 1st Edition by Shaker A Mousa, Raj Bawa, Gerald F Audette ISBN 1003027016 9789814800983

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ISBN 10: 1003027016 
ISBN 13: 9789814800983
Author: Shaker A Mousa, Raj Bawa, Gerald F Audette

The Road from Nanomedicine to Precision Medicine Part A 1st Table of contents:

1. Drug Delivery at the Nanoscale: A Guide for Scientists, Physicians and Lawyers
1.1 Nano Frontiers: An Introduction
1.2 The Arrival of Modern Nanotechnology
1.3 Drug Delivery in the Context of Nano: Terminology Matters
1.4 Views of the Nanoworld: Physical Scientists versus Drug Developers
1.5 US Food and Drug Administration
1.6 What Is a Biologic?
1.7 Size Matters in Drug Delivery
1.8 What Are Nanodrugs?
1.9 Nanodrugs in the Era of Generics
1.10 FDA Regulation of Nanodrugs: Gaps and Baby Steps on a Bumpy Road
1.11 Protecting Inventions via US Patents
1.12 Bench-to-Bedside Translation of Nanomedicine
1.13 Concluding Remarks and Future Prospects
2. What Is Precision Medicine? A Primer on Contemporary Issues and Concerns
2.1 Introduction
2.2 From Personalized to Precision Medicine
2.3 How We Arrived at Our Definition of Precision Medicine
2.4 Data Collection to Support Precision Medicine Research Efforts
2.5 Themes and Issues in Precision Medicine
2.6 Conclusions
3. FDA’s Role in Paving the Way for Personalized Medicine
3.1 Introduction
3.2 Personalized Medicine from a Regulatory Perspective
3.3 Driving Toward and Responding to Scientific Advances
3.4 Defining and Clarifying Regulatory Pathways and Policies
3.5 Advancing Regulatory Science in Support of Personalized Medicine
3.6 A New Era of Medical Product Development: Opportunities and Challenges Ahead
4. Multifunctional Gold Nanoparticles in Drug Delivery Systems
4.1 Introduction
4.2 Gold Nanoparticle Synthesis: The Construct Base
4.3 Gold Nanoparticle Targeting and Imaging
4.4 Multifunctional Gold Nanoparticles in Drug Delivery Systems
4.5 Conclusion
5. Nanoparticles and Nanoparticulate Drug Delivery Systems: Impact of Size and Structure on Functionality
5.1 Introduction
5.2 Functionality: Biopharmaceutical and Pharmacokinetic Modification
5.3 Impact of Size and Structure on Functionality
5.4 Quality Attributes and Analytical Tools
5.5 Conclusions
6. Self-Assembling Peptide Amphiphiles as a Versatile Future Nanomedicine Platform
6.1 Introduction
6.2 Mechanisms for Peptide Amphiphile Self-Assembly
6.3 Self-Assembling PA Applications
6.4 The Current Status of Therapeutic Peptides and the Future of PA Systems
7. Pharmaceutical Applications of Water-Soluble Polymers in Nanomedicine and Drug Delivery
7.1 Introduction
7.2 Pharmaceutical Applications of Polymers in Nanomedicine
7.3 Polymer Preparation
7.4 Polymers in Pharmaceuticals
7.5 Xanthan Gum
7.6 Conclusion
8. Nanomaterials: Tools, Technology, and Methodology of Nanotechnology-Based Biomedical Systems for Diagnostics and Therapy
8.1 Introduction
8.2 Definition of Terms
8.3 Applications of Nanotechnology to Life Sciences
8.4 Comparing Theranostic Features Using a Better than a Random Guess Value
8.5 Perspective
9. Nanomagnetic Resonance Imaging (Nano-MRI) Gives Personalized Medicine a New Perspective
9.1 Introduction
9.2 Personalized Medicine
9.3 Molecular Imaging
9.4 Nanomagnetic Resonance Imaging
9.5 Nitrogen-Vacancy Center Magnetometry
9.6 Nanocrystals
9.7 Conclusions
10. Advancing Precision Medicine: Tailoring Personalized Therapies
10.1 Introduction
10.2 Ex vivo Models Predict Treatment Responses
10.3 Real-Time Monitoring of Treatment Responses and ex vivo Guided Personalized Treatments
10.4 Metabolic Profiling Enhances Mutational Profiling
10.5 Real Time Mutational Profiling Led Risk Stratification
10.6 Circulating Biomarker Led Detection of High-Risk Patients
10.7 Discussion and Concluding Remarks
11. Precision Medicine for Alzheimer’s Disease Prevention
11.1 Introduction to Precision Medicine
11.2 “One-Size-Fits-All” Approach to AD Prevention
11.3 Precision Medicine Approach to AD Prevention
11.4 APOE and AD Prevention
11.5 MTHFR and AD Prevention
11.6 Other Genetic Influencers on AD Prevention
11.7 Conclusions and Future Directions
12. Advanced Porphyrin Nanomaterials for Biological Applications
12.1 Introduction
12.2 Emerging Applications of Porphyrins
12.3 Porphyrin-Containing Nanoscale Materials
12.4 Conclusion
13. Cerium Oxide Nanoparticles as a Novel Reactive Oxygen Modulating Nanodrug
13.1 Introduction
13.2 Nanomedicine
13.3 Conclusions
14. Artificial Nanomachines and Nanorobotics
14.1 Introduction
14.2 Biologically Inspired Molecular Nanomotors
14.3 Artificially Fabricated Nanomachines
14.4 First-Generation Nanorobots with Autonomy Locomotion
14.5 Nubots
14.6 Shape-Shifting Nanorobot
14.7 Bionanorobotics
14.8 Future Perspectives
15. Nanomotors for Nucleic Acid, Protein, Pollutant, and Cell Detection
15.1 Introduction
15.2 Nanomotors for Protein Detection
15.3 Nanomotors for Nucleic Acid Detection
15.4 Nanomotors for Pollutants and Small Molecules Detection
15.5 Nanomotors for Cell Capture
15.6 Conclusions
16. Magneto-Responsive Scaffolds for Tissue Engineering Applications
16.1 Introduction
16.2 Magnetic Nanoparticles in Tissue Engineering
16.3 Synthesis of Magneto-Responsive Biomaterials
16.4 Magneto-Responsive Biomaterials for Tissue Regeneration Applications
16.5 Concluding Remarks
17. Anti-Cancer and Anti-Angiogenic Properties of Nano-Diamino-Tetrac, A Thyroid Hormone Derivative
17.1 Introduction
17.2 Tetrac, Nanotetrac (Nano-diamino-tetrac, NDAT) and Angiogenesis
17.3 Anti-Cancer Properties of Nanotetrac
17.4 Pharmacodynamics of Nanotetrac
17.5 Side Effect Profile of Nanotetrac
17.6 Conclusions

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