The Nuclear Envelope Vol 56 1st Edition by David Evans, Chris Hutchison, John Bryant – Ebook PDF Instant Download/Delivery: 1134279787, 9781134279838
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Product details:
ISBN 10: 1134279787
ISBN 13: 9781134279838
Author: David Evans, Chris Hutchison, John Bryant
The Nuclear Envelope Vol 56 1st Table of contents:
1. The Nuclear Envelope: A Comparative Overview
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A general description of the nuclear envelope
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Nuclear envelope formation
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Nuclear pore complexes and transport across the nuclear envelope
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Nuclear lamina
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Proteins of the nuclear envelope
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Conclusion
2. The Nuclear Envelope Proteome
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Introduction
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Structure of the nuclear envelope
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Strategies in nuclear envelope proteomics
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Proteins of the nuclear envelope
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Conclusions
3. Nuclear Envelope Proteins and Human Disease
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Nuclear envelope: overall structure
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Integral proteins of the inner nuclear membrane of vertebrates
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Nuclear lamina and the human nuclear lamin gene family
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Invasion of the positional cloners
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Mouse models of human diseases caused by nuclear envelope protein mutations
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How do mutations in emerin and lamins A and C cause the same disease?
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How do mutations in widely expressed proteins cause tissue-specific diseases?
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How do different mutations in lamins A and C cause different diseases?
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Conclusions
4. Protein Interactions, Right or Wrong, in Emery-Dreifuss Muscular Dystrophy
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Introduction
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Nuclear foci of A-type lamins
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Cell division, degeneration and death
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Interactions of emerin with other proteins
5. Plant Nuclear Envelope Proteins
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Introduction
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The plant nuclear envelope as scaffold for macromolecular complexes
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Targeting across and into the plant nuclear envelope
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Signal transduction at the plant nuclear envelope
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Summary
6. Structure, Function and Assembly of the Nuclear Pore Complex
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Introduction
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NPC structure
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Annulate lamellae
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Identification of the NPC proteome
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NPC protein complexes and their functions
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Traversing the nuclear pore
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NPC assembly
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The molecular requirements for NPC assembly
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Nucleoporins and disease
7. Import and Export at the Nuclear Envelope
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Introduction
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The soluble phase of transport
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Role of NPC in transport
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Summary
8. Regulating Gene Expression in Mammalian Cells: How Nuclear Architecture Influences mRNA Synthesis and Export to the Cytoplasm
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Introduction
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Initiating gene expression
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Chromatin structure and gene expression
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Chromatin modification
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Spatial nuclear architecture
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Transcription centres
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Nuclear architecture and chromosome structure
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The nuclear matrix
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Nuclear compartments
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Proteins of the nuclear matrix—links to function
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The nucleoskeleton and nuclear lamina—common themes
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The lamin genes
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Lamin function
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Internal nuclear lamins
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The pathway of gene expression—from gene to cytoplasm
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RNA export pathways
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Nuclear transport—facilitated diffusion
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Gene regulation and transcript stability
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Conclusions
9. Nuclear Shuttling in Plant Cells
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Introduction
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Nuclear import and export
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Plant virus movement proteins
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Concluding remarks
10. Dynamics of Nuclear Lamina Assembly and Disassembly
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Introduction
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Lamina dynamics in interphase cells
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Lamin dynamics during mitosis
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Dynamics of the lamina during apoptosis
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Summary
11. Spatial and Temporal Control of Nuclear Envelope Assembly by Ran GTPase
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Introduction
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Control of nuclear envelope assembly by Ran
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Summary
12. Nuclear Envelope Dynamics During Mitosis
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Introduction
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The nuclear envelope
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Nuclear envelope breakdown
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The role of dynein
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The kinetochore connection
13. Nuclear Dynamics in Higher Plants
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Introduction
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The structure of plant nuclei as revealed using GFP targeting
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Nuclear movement
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Nuclear fragmentation
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Dynamic movement of chromosomes and chromatin within the nucleus
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What mediates the nuclear shape changes?
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Prospects and future directions
14. The Nuclear Envelope in the Plant Cell Cycle
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Introduction
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An overview of plant cell division
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A survey of key elements of the endomembrane system involved in the mitotic apparatus
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Traffic of components of the plant NE and of other membranes during cell division
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Targeting to the plant NE
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Mechanisms for the breakdown and reformation of the plant NE and for protein traffic during this process
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Unanswered questions and future prospects
15. Signalling to the Nucleus via A-Kinase Anchoring Proteins
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Summary
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Introduction
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Intracellular targeting of cAMP signalling by A-kinase anchoring proteins
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Regulation of chromosome dynamics and nuclear function by AKAP95
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Integration of cAMP and Ca²⁺ signalling at the cardiomyocyte nuclear envelope by mAKAP
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Targeting of PP1 to the nuclear envelope by AKAP149: implications on cell cycle progression
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Developmentally regulated nAKAP150
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A novel nuclear envelope-chromatin interaction: involvement in DNA replication
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Conclusions
16. Spectraplakins and Nesprins, Giant Spectrin Repeat Proteins Participating in the Organization of the Cytoskeleton and the Nuclear Envelope
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Spectraplakins organize actin and microtubule cytoskeletons
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The identification of novel spectrin repeat proteins in the nucleus and nuclear membrane
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Conclusions
17. Arabidopsis U1 snRNP 70K Protein and Its Interacting Proteins: Nuclear Localization and In Vivo Dynamics of a Novel Plant-Specific Serine/Arginine-Rich Protein
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Introduction
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U1-70K is essential in plants
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Arabidopsis U1-70K interacts with a novel set of SR proteins
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A LAMMER-type protein kinase (AFC2) phosphorylates several plant SR proteins
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Localization and in vivo dynamics of SR45
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Conclusions
18. Calcium/Calmodulin-Binding Transcription Activators in Plants and Animals
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Calcium: a versatile biological signal
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Calmodulin as a calcium sensor
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Regulation of Ca²⁺/CaM flux by the nuclear envelope
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CaM-binding proteins
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Regulation of transcription
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CaM-regulated transcription factors
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Future perspectives
19. CAAX-Dependent Modifications of the Lamin Proteins in the Organization of the Nuclear Periphery
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Introduction
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The biochemistry of lamin CAAX processing
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Biological consequences of CAAX processing of the nuclear lamins
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Defects of lamin CAAX processing: drugs and diseases
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Conclusions
20. All in the Family: Evidence for Four New LEM-Domain Proteins Lem2 (NET-25), Lem3, Lem4 and Lem5 in the Human Genome
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Summary
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Introduction to LEM-domain proteins, their functions in the nucleus and links to ‘laminopathy’ disease
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Evidence for more LEM-domain proteins in the human genome
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Other new LEM-domain proteins?
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