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The Language Of Life How Cells Communicate In Health Disease 1st Edition by Debra Niehoff ISBN 0309102014 9780309102018

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The Language Of Life How Cells Communicate In Health Disease 1st Edition Debra Niehoff Digital Instant Download

Author(s): Debra Niehoff
ISBN(s): 9780309089890, 0309089891
Edition: 1
File Details: PDF, 6.11 MB
Year: 2005
Language: english
SKU: EB-1019968 Category: Tag:

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Product details:
ISBN 10: 0309102014
ISBN 13: 9780309102018
Author: Debra Niehoff
Cooperation requires conversation. Human beings speak to one another. Sounds, scents, and postures allow animals to make their point. While individual cells can’t talk, hiss, growl, or bare their teeth, they nevertheless communicate regularly. Their language is based not on words or gestures, but on chemistry —using molecules where we would use words, constructing sentences from chains of proteins. The cells that make up the bodies of muticellular organisms inform, wheedle, command, exhort, reassure, nurture, criticize, and instruct each other to direct every physiological function, report every newsworthy event, record every memory, heal every wound. And each of those chemical conversations represents an opportunity for scientists and physicians.

The molecular biologists who worked for over a decade to sequence the human genome have sometimes referred to that sequence as the “book of life.” To our cells, that “book” is no more than a dictionary—only living cells can converse, forming the network that allows our 60 trillion cells to function as a single organism.

For nearly a century, researchers have been straining to hear the whispered conversations among cells, hoping to master the basics of their language. They know that if we can decipher and translate this cellular chatter, we have the potential for sending signals of our own that could repair wounds, reduce cholesterol, control insulin levels, or even block the reproduction of cancer cells. The possibilities are as endless as they are intriguing. The Language of Life is a fantastic story of discovery, blending the vision of science with the poetry of life itself.

The Language Of Life How Cells Communicate In Health Disease 1st Edition Table of contents:

  • Chapter 1: The Foundations of Cellular Communication

    • Overview of the concept of cellular communication and its role in the body.
    • The history of cellular signaling research.
    • Basic principles: signal reception, transduction, and response.
    • Types of cellular signals: chemical, electrical, and mechanical signals.

  • Chapter 2: Molecular Signals and Their Pathways

    • The role of molecules like hormones, neurotransmitters, and cytokines.
    • Signal receptors: how cells detect and respond to stimuli.
    • Key signaling pathways: G-protein-coupled receptors (GPCRs), kinases, and transcription factors.
    • Intracellular signaling and second messengers (e.g., calcium, cyclic AMP).

  • Chapter 3: The Language of the Cell: Receptors and Messengers

    • Structure and function of receptors.
    • Ligands and how they bind to receptors.
    • The role of messengers in amplifying signals inside the cell.
    • Feedback mechanisms in cellular communication.

  • Chapter 4: Cell Communication in Development and Homeostasis

    • How cells communicate to coordinate development and growth.
    • The role of signaling in stem cell differentiation and tissue formation.
    • Maintaining homeostasis through cell signaling: feedback loops and balance.
    • The concept of cell “crosstalk” in multicellular organisms.

  • Chapter 5: Disruptions in Cellular Communication: The Basis of Disease

    • How disruptions in signaling pathways can lead to diseases such as cancer, autoimmune disorders, and neurological diseases.
    • Genetic mutations and signaling pathway alterations.
    • The role of inflammation and cytokine storms in disease development.
    • Aberrant signaling in cancer: oncogenes and tumor suppressor genes.

  • Chapter 6: The Role of the Immune System in Cellular Communication

    • How immune cells communicate with each other and other cells in the body.
    • The role of cytokines, chemokines, and antigen presentation.
    • Immune response modulation and tolerance.
    • Dysregulated immune signaling in autoimmune diseases and immunodeficiencies.

  • Chapter 7: Neurotransmission and Neural Communication

    • Understanding how nerve cells communicate across synapses.
    • The role of neurotransmitters and receptors in synaptic signaling.
    • Neuronal signaling and its impact on behavior, learning, and memory.
    • Disorders related to disrupted neural communication, such as Alzheimer’s and Parkinson’s diseases.

  • Chapter 8: Hormonal Signaling and Its Impact on Health

    • Overview of endocrine signaling and hormone action.
    • The role of hormones in regulating metabolism, growth, and reproduction.
    • Disruptions in hormonal signaling: endocrine diseases and metabolic disorders.
    • The impact of stress hormones on the body’s response to disease.

  • Chapter 9: Communication Between Cells in Multicellular Organisms

    • The role of gap junctions, tight junctions, and adherens junctions in cell-to-cell communication.
    • Extracellular matrix (ECM) signaling and its impact on tissue architecture and function.
    • How cells coordinate to form functional organs and tissues.
    • The role of signaling in wound healing and tissue repair.

  • Chapter 10: The Impact of Environmental Factors on Cell Communication

    • Environmental toxins, radiation, and pathogens as disruptors of cellular communication.
    • The effects of diet, stress, and lifestyle on signaling pathways.
    • Epigenetic changes induced by environmental factors.
    • How environmental influences can lead to disease through altered cell signaling.

  • Chapter 11: Advances in Cell Communication Research

    • Current research trends in cellular signaling and communication.
    • The role of omics technologies (genomics, proteomics, metabolomics) in understanding cell communication.
    • Targeted therapies based on signaling pathway modulation.
    • The future of personalized medicine and therapeutic interventions based on cellular communication.

  • Chapter 12: Cell Communication and Aging

    • How cell communication changes with age.
    • The role of cellular senescence and its impact on aging-related diseases.
    • Age-related decline in signaling pathways and its effects on tissue repair and regeneration.
    • Interventions and lifestyle factors that can modulate aging-related signaling.

  • Conclusion: The Language of Life and Its Role in Human Health

    • A synthesis of key concepts discussed in the book.
    • The importance of understanding cellular communication for advancing health care and disease treatment.
    • Future directions in research and medical therapies related to cell signaling.

  • Glossary

    • Definitions of key terms and concepts related to cell communication.

  • References

    • A comprehensive list of academic references and research articles cited throughout the book.

  • Index

    • An alphabetical index for quick reference to specific topics discussed in the book.

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