The IACUC Handbook 3d Edition by Jerald Silverman, Mark A. Suckow, Sreekant Murthy ISBN 1466555645 9781466555648

Part I: Foundations of Animal Care and Use

• Chapter 1: Introduction to the IACUC and Animal Welfare:

  • The History and Evolution of Animal Research Regulations
  • The Three Rs (Replacement, Reduction, Refinement)
  • The Role of the IACUC
  • Institutional Animal Care and Use Committee (IACUC) Membership and Responsibilities
  • Ethical Considerations in Animal Research

• Chapter 2: Federal Regulations and Guidance:

  • The Animal Welfare Act (AWA) and its Regulations
  • Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals
  • Guidance from the Office of Laboratory Animal Welfare (OLAW)
  • International Harmonization of Animal Welfare Standards

• Chapter 3: Animal Welfare Principles:

  • Housing and Environmental Enrichment
  • Husbandry and Animal Care Techniques
  • Pain Management and Euthanasia
  • Humane Endpoint Determination

• Chapter 4: Species-Specific Considerations:

  • Rodents, Rabbits, and other common lab animals
  • Non-human primates, dogs, cats, and other species
  • Aquatic animals, birds, and other unique considerations

Part II: IACUC Operations and Procedures

• Chapter 5: Protocol Review and Approval:

  • Protocol Development and Submission
  • IACUC Review Process (Including documentation and record keeping)
  • Criteria for Protocol Approval
  • Handling Protocol Amendments and Modifications

• Chapter 6: Facility Oversight and Inspections:

  • Facility Design and Maintenance
  • Environmental Monitoring and Management
  • Program and Personnel Inspections

• Chapter 7: Investigator Responsibilities:

  • Training and Education Requirements for Researchers
  • Maintaining Records and Reporting Requirements
  • Reporting Adverse Events and Protocol Deviations

• Chapter 8: Training and Education:

  • IACUC Member Training
  • Investigator Training Programs
  • Technician and Staff Training Programs

• Chapter 9: Record Keeping and Reporting:

  • Maintaining Accurate and Comprehensive Records
  • Reporting Requirements to Regulatory Agencies (e.g., USDA, OLAW)
  • Data Management and Analysis

Part III: Specialized Topics

• Chapter 10: Field Studies and Wildlife Research: Unique considerations for research outside of laboratory settings
• Chapter 11: Genetic Engineering and Transgenic Animals: Ethical and welfare considerations
• Chapter 12: The Use of Anesthesia, Analgesia, and Sedation: Best practices and pain management
• Chapter 13: Euthanasia Techniques: Humane methods and considerations

Part IV: Appendices

• Appendix A: Sample IACUC Forms and Templates
• Appendix B: Relevant Legislation and Regulations
• Appendix C: Resource List (Organizations, Websites, Publications)
• Appendix D: Glossary of Terms