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Target Identification and Validation in Drug Discovery Methods and Protocols 1st Edition by Marta Cortes Cros ISBN 1627033106 9781627033107

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Target Identification and Validation in Drug Discovery Methods and Protocols 1st Edition Marta Cortés-Cros Digital Instant Download

Author(s): Marta Cortés-Cros, Tobias Schmelzle, Volker M. Stucke, Francesco Hofmann (auth.), Jurgen Moll, Riccardo Colombo (eds.)
ISBN(s): 9781627033107, 1627033106
Edition: 1
File Details: PDF, 4.78 MB
Year: 2013
Language: english
SKU: EB-4318150 Category: Tags: , , , , ,

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ISBN 10: 1627033106 
ISBN 13: 9781627033107
Author: Marta Cortes Cros

This third edition book explores breakthrough techniques in the field of drug target identification and validation. With technologies and methodologies ranging from target identification to the analysis of clinical samples, as well as newer areas like artificial intelligence and machine learning applications, the book will aid decision-makers in drug development by offering a succinct overview of the available technologies for portfolio management. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and up-to-date, Target Identification and Validation in Drug Discovery: Methods and Protocols, Third Edition will help a diverse audience of scientists find valuable insights to address their drug development inquiries.

Target Identification and Validation in Drug Discovery Methods and Protocols 1st Table of contents:

Part I: Background

  1. The Path to Oncology Drug Target Validation – an Industry Perspective

Part II: DNA as a Tool to Modulate Drug Targets
2. Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity
3. The Design and Structure-Functional Properties of DNA-Based Immunomodulatory Sequences

Part III: RNA Interference: From Design to Data Analysis
4. siRNA Design Principles and Off-Target Effects
5. Western Blot Evaluation of siRNA Delivery by pH Responsive Peptides
6. High-Throughput RNAi Screening for the Identification of Novel Targets
7. Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development
8. CellProfiler and KNIME: Open Source Tools for High-Content Screening
9. PARP Inhibition as a Prototype for Synthetic Lethal Screens

Part IV: Protein-Focused Technologies
10. Structure-Based Target Druggability Assessment
11. Validating Pharmacological Disruption of Protein‑Protein Interactions by Acceptor Photobleaching FRET Imaging
12. Systematic Analysis of Complex Signal Transduction Pathways using Protein Fragment Complementation Assays
13. Reverse‑Phase Protein Microarrays and Their Utility in Drug Development

Part V: Innovative Cell Culture Techniques to Mimic Tissue Microenvironments
14. A Cell Culture System that Mimics Chronic Lymphocytic Leukemia Microenvironment for Drug Screening and Characterization
15. Two‑Dimensional vs. Three‑Dimensional In Vitro Tumor Migration and Invasion Assays
16. Tumor Spheroid‑based Migration Assays for Evaluation of Therapeutic Agents
17. The NeuroSphere Assay (NSA) Applied to Neural Stem Cells (NSCs) and Cancer Stem Cells (CSCs)

Part VI: Genetically Engineered Animal Models to Study Gene Functions
18. Genetically Engineered Animal Models for In Vivo Target Identification and Validation in Oncology
19. Target Validation in Mice by Constitutive and Conditional RNAi
20. In Vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models

Part VII: Translational Methods to Validate Biomarkers
21. Brightfield In Situ Hybridization Methods to Discover Gene Amplifications and Rearrangements in Clinical Samples
22. Combined microRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers

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Tags: Marta Cortes Cros, Target Identification, Drug Discovery