T Cell Subsets Cellular Selection Commitment and Identity 1st Edition by Harvey Cantor, Laurie Glimcher, Frederick Alt ISBN 0120224836 ‎ 978-0120224838

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ISBN 10: 0120224836
ISBN 13: ‎ 978-0120224838
Author: Harvey Cantor, Laurie Glimcher, Frederick Alt 

This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers

T Cell Subsets Cellular Selection Commitment and Identity 1st Table of contents:

Chapter 1. Lineage Commitment and Developmental Plasticity in Early Lymphoid Progenitor Subsets

I. Introduction

II. Hematopoietic Stem Cells: Clonogenic Precursors of the Hematolymphoid System

III. Cell Fate Determination: How do HSCs Commit to Each of the Hematolymphoid Lineages?

IV. Overview of T and B Lymphoid Differentiation

V. Defining the Earliest Stage in Lymphoid Commitment: Isolation of Common Lymphoid Progenitors (CLP

VI. Is the CLP Stage Necessary for Adult Lymphoid Differentiation?

VII. Common Myeloid Progenitors as the Counterpart of CLPs

VIII. Lineage Priming by Promiscuous Gene Expression in Multipotent Stem and Progenitor Cells

IX. Lymphoid and Myeloid Promiscuity Demonstrated by Single-Cell Analyses

X. Fate Choices Made by Combinations of Instructive Signals at Lineage Promiscuous Stages

XI. Lineage Plasticity in Lymphoid Progenitors: Fate Choices are Reversible

XII. Comparison of Gene Expression Profiles among Early Hematopoietic Stem and Progenitor Cells

XIII. Early Lymphoid Progenitors can Differentiate into Antigen-presenting Dendritic Cells

XIV. Fetal Hematopoietic Progenitors are Not Fully Committed to the Lymphoid and Myeloid Fates

XV. Lymphoid- and Myeloid-restricted Progenitors in Human Bone Marrow

XVI. Clinical Relevance

XVII. Conclusion

References

Chapter 2. The CD4/CD8 Lineage Choice: New Insights into Epigenetic Regulation during T Cell Develop

I. Introduction

II. Role of Coreceptors in T Cell Development

III. Regulation of CD4 Gene Expression

IV. Regulation of CD8 Gene Expression

V. Conclusion

References

Chapter 3. CD4/CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis

I. Introduction

II. Early Thymocyte Development

III. CD4 and CD8 Coreceptor Molecules on DP Thymocytes

IV. Selection and Commitment: Classical Models

V. Kinetic Signaling as an Alternative to Classical Models of Lineage Commitment

VI. Conclusions

References

Chapter 4. Development and Function of T Helper 1 Cells

I. Introduction

II. Factors Inducing the Development of Th1 Cells And Their Production of IFN-γ

III. Role of Th1 Signaling Components in In Vivo Immune Responses

IV. Transcriptional Regulation for Th1 Cells Producing IFN-γ

V. New Cytokines: What is Their Role in Th1 Cell Responses?

VI. Inherited Disorders of IL-12 and IFN-γ-mediated Immunity: Clinical Outcomes of Defects in Th1 D

References

Chapter 5. Th2 Cells: Orchestrating Barrier Immunity

I. Introduction: History and Definitions

II. Activation of IL-4 Expression in Naive CD4 T Cells

III. Stabilization of IL-4 Expression in T Cells

IV. Phenotype and Genotype Analysis of Th2 Cells

V. Mutations Impacting IL-4 Expression in T Cells

VI. Expression of IL-4 in Non-Th2 Cells

VII. Where Does Type 2 Immunity Operate?

VIII. Concluding Remarks

References

Chapter 6. Generation, Maintenance, and Function of Memory T Cells

I. Introduction

II. What Is a Memory Cell?

III. Where Do Memory CD8+ T Cells Come From?

IV. How Are Memory Cells Maintained?

V. Conclusions

References

Chapter 7. CD8+ Effector Cells

I. Effector Cells Defined

II. Secretion as the Mechanism of Effector Function

III. Cytotoxicity In Vivo

IV. Cytotoxicity In Vitro

V. Perforin-dependent Granule Exocytosis Pathway

VI. FasL/Fas Death Pathway

VII. Cytokine Secretory Effector Cells

VIII. CD8+ T Cell Differentiation

IX. Conclusions

References

Chapter 8. An Integrated Model of Immunoregulation Mediated by Regulatory T Cell Subsets

I. Introduction and Objectives

II. Historical Considerations: Clonal Selection Theory, Immunoregulation, and Regulatory T Cell Subs

III. The T Cell Subsets which Mediate Suppression of the Immune Response

IV. An Integrated Model of Immunoregulation by NKT, CD4+CD25+, and Qa-1 Restricted CD8+ T Cell Sub

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