Sale!

Systems Biology of Clostridium 1st Edition by Peter Durre ISBN 1783264403 9781783264407

Original price was: $50.00.Current price is: $35.00.

Systems Biology of Clostridium 1st Edition Peter Durre (Ed.) Digital Instant Download

Author(s): Peter Durre (ed.)
ISBN(s): 9781783264407, 1783264403
Edition: 1
File Details: PDF, 9.69 MB
Year: 2014
Language: english
SKU: EB-5242396 Category: Tag:

Systems Biology of Clostridium 1st Edition by Peter Durre – Ebook PDF Instant Download/Delivery: 1783264403, 9781783264407
Full download Systems Biology of Clostridium 1st Edition after payment

Product details:

ISBN 10: 1783264403 
ISBN 13: 9781783264407
Author: Peter Durre

Systems Biology of Clostridium provides a comprehensive overview of system biology approaches in clostridia, especially Clostridium acetobutylicum. Systems biology is a rapidly evolving scientific discipline that allows us to understand and predict the metabolism and its changes within the bacterium as a whole.Clostridia represent one of the largest bacterial genera. This group contains organisms with metabolic properties that hold enormous potential for biotechnological processes. A model organism is Clostridium acetobutylicum that has been, and is still used in large-scale industrial production of the solvents acetone and butanol. Systems biology offers a new way to elucidate and understand the complex regulatory network controlling the different metabolic pathways and their interactions. All aspects from the development of appropriate experimental tools to mathematical modeling are covered, including a fascinating historical account on acetone-butanol fermentation in World War II.Written by world-class experts in their fields, Systems Biology of Clostridium is an essential source of reference for all biologists, biochemists, chemists, and chemical engineers working on biotechnological fermentations or industrial applications, as well as biofuels.

Systems Biology of Clostridium 1st Table of contents:

Chapter 1: Metabolic and Regulatory Networks in Clostridium acetobutylicum

  • 1.1 Introduction

  • 1.2 Roadmap to modeling

  • 1.3 Regulators of solventogenesis and sporulation in C. acetobutylicum

  • Supplementary material

  • References

Chapter 2: Clostridial Gene Tools

  • 2.1 Introduction

  • 2.2 Clostridial gene transfer

  • 2.3 Clostridial vector systems

  • 2.4 Tools for forward genetics studies
      - 2.4.1 Conjugative transposons
      - 2.4.2 Non-conjugative transposons

  • 2.5 Recombination-based tools for reverse genetic studies
      - 2.5.1 Mutants in pathogenic clostridia
      - 2.5.2 Solventogenic clostridia
      - 2.5.3 Negative selection markers

  • 2.6 Reverse genetic tools based on recombination-independent methods
      - 2.6.1 Group II introns
      - 2.6.2 Targetron-mediated inactivation of clostridial genes
      - 2.6.3 Positive selection of gene inactivation

  • 2.7 The ClosTron: a universal gene knock-out system for clostridia
      - 2.7.1 ClosTron development
      - 2.7.2 The prototype ClosTron system
      - 2.7.3 ClosTron procedure refinements

  • 2.8 Conclusions

  • Acknowledgement

  • References

Chapter 3: Supporting Systems Biology of Clostridium acetobutylicum by Proteome Analysis

  • 3.1 Introduction

  • 3.2 Stress proteomes of C. acetobutylicum

  • 3.3 Sample preparation and proteome reference maps

  • 3.4 Effects of the metabolic shift on the proteome

  • 3.5 Proteome data and transcriptome data: a comparison

  • 3.6 Conclusions and outlook

  • Acknowledgement

  • References

Chapter 4: Comparative Genomic Analysis of the General Stress Response in Clostridium acetobutylicum and Clostridium beijerinckii

  • 4.1 Introduction

  • 4.2 Class I heat shock proteins

  • 4.3 Class II heat shock proteins

  • 4.4 Class III heat shock proteins

  • 4.5 Class IV–VI heat shock proteins

  • 4.6 Heat shock proteins (HSPs) and solvent tolerance

  • 4.7 Conclusions

  • Acknowledgement

  • References

Chapter 5: Mathematical Modeling of the pH-Induced Metabolic Shift in Clostridium acetobutylicum

  • 5.1 Industrial application of C. acetobutylicum

  • 5.2 AB fermentation in C. acetobutylicum

  • 5.3 Modeling the pH-dependent metabolic switch
      - 5.3.1 AB fermentation in a continuous stirred-tank reactor
      - 5.3.2 pH-induced changes of transcriptome and proteome
      - 5.3.3 Impact of pH on biochemical reactions
      - 5.3.4 Dynamic modeling of the metabolic shift

  • 5.4 Conclusions and outlook

  • Acknowledgement

  • References

Chapter 6: Mathematical Models for Clostridia: From Cultivation Description to Systems Biology

  • 6.1 Introduction

  • 6.2 Models for the ABE fermentation process
      - 6.2.1 History
      - 6.2.2 Batch fermentation with C. acetobutylicum
      - 6.2.3 Continuous fermentation with C. acetobutylicum

  • 6.3 Models for processes beyond ABE fermentation
      - 6.3.1 Growth models for C. perfringens
      - 6.3.2 Biohydrogen production by clostridia

  • 6.4 Outlook

  • Nomenclature

  • References

Chapter 7: Modelling agr-Dependent Quorum Sensing in Gram-Positive Bacteria

  • 7.1 Quorum sensing: gene regulation and cell density

  • 7.2 agr-type quorum sensing systems

  • 7.3 Mathematical models of quorum sensing

  • 7.4 Model formulation

  • 7.5 Numerical solutions

  • 7.6 Relevance to clostridial systems biology

  • Acknowledgement

  • References

Chapter 8: Comparative Genomic Analysis of the Central Metabolism of Clostridium acetobutylicum and Clostridium beijerinckii

  • 8.1 Introduction

  • 8.2 General genome features

  • 8.3 Central catabolic pathways
      - 8.3.1 Glucose uptake
      - 8.3.2 Glycolysis
      - 8.3.3 Gluconeogenesis
      - 8.3.4 Pyruvate conversion
      - 8.3.5 Acetyl-CoA conversion
      - 8.3.6 Energy generation and disposal of reducing equivalents

People also search for Systems Biology of Clostridium 1st:

    
clostridium organisms
    
clostridium b
    
clostridium botulinum osmosis
    
clostridia (class)
    
a system of classification grouping organisms into 3 domains

Tags: Peter Durre, Systems Biology, Clostridium