Surface Modification of Biomaterials Methods Analysis and Applications 1st Edition by Rachel Williams 1845696409 9781845696405
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ISBN 10:1845696409
ISBN 13:9781845696405
Author:Rachel Williams
The surface modification of biomaterials plays a significant role in determining the outcome of biological-material interactions. With the appropriate modification a material’s surface can be tailored to improve biocompatibility, adhesion and cell interactions. Consequently surface modification is vital in the development and design of new biomaterials and medical devices. Surface modification of biomaterials reviews both established surface modifications and those still in the early stages of research and discusses how they can be used to optimise biological interactions and enhance clinical performance.
Part one begins with chapters looking at various types and techniques of surface modification including plasma polymerisation, covalent binding of poly (ethylene glycol) (PEG), heparinisation, peptide functionalisation and calcium phosphate deposition before going on to examine metal surface oxidation and biomaterial surface topography to control cellular response with particular reference to technologies, cell behaviour and biomedical applications. Part two studies the analytical techniques and applications of surface modification with chapters on analysing biomaterial surface chemistry, surface structure, morphology and topography before moving onto discuss modifying biomaterial surfaces to optimise interactions with blood, control infection, optimise interactions with soft tissues, repair and regenerate nerve cells, control stem cell growth and differentiation and to optimise interactions with bone.
The distinguished editor and international team of contributors to Surface modification of biomaterials have produced a unique overview and detailed chapters on a range of surface modification techniques which will provide an excellent resource for biomaterials researchers and scientists and engineers concerned with improving the properties of biomaterials. It will also be beneficial for academics researching surface modification.
- Reviews both established surface modifications and those still in the early stages of research and how they can be used to optimise biological interactions and enhance clinical performance
- Studies analytical techniques and applications of surface modification with chapters assessing biomaterial surface chemistry, surface structure, morphology and topography
- Discusses modifying biomaterial surfaces to optimise interactions with blood and soft tissues and also to repair and regenerate nerve cells and control infection
Surface Modification of Biomaterials Methods Analysis and Applications 1st Table of contents:
Part I Surface modification techniques
1 Surface modification of biomaterials by plasma polymerization
1.1 Introduction
1.2 An overview of plasma and plasma polymerization
1.3 Plasma generation and systemdesign
1.4 Plasma parameters
1.5 Intrinsic parameters
1.6 Potential biomaterial applications
1.7 Future trends in plasma polymers
1.8 Sources of further information and advice
1.9 References
2 Surface modification of biomaterials by covalent binding of poly(ethylene glycol) (PEG)
2.1 Introduction
2.2 Principles andmethods
2.3 Technologies and applications
2.4 Conclusions and future trends
2.5 References
3 Surface modification of biomaterials by heparinisation to improve blood compatibility
3.1 Introduction
3.2 Bioactivemolecule: heparin
3.3 Blood−biomaterial interaction
3.4 Surface modification by heparinisation for improved blood compatibility
3.5 Future trends in heparinisation of biomaterial surfaces
3.6 References
4 Surface modification of biomaterials by peptide functionalisation
4.1 Introduction
4.2 Peptides and peptide functionalisation of surfaces
4.3 Defining the biomaterial surface
4.4 Peptide functionalised surfaces
4.5 Non-covalent peptide functionalisation by self-assembly
4.6 Spatial control of peptide functionality
4.7 Conclusions
4.8 References
5 Metal surface oxidation and surface interactions
5.1 Surface oxides inmetallic medical devices: the scenario
5.2 Titaniumoxides on Ti implants: from crystallographic structure to the theoretical study of the a
5.3 Technologies for tailoring Ti oxides on titanium
5.4 Future trends
5.5 References
5.6 Appendix A: Materials andmethods for unpublished results
5.7 Appendix B: Abbreviations and symbols
6 Surface modification of biomaterials by calcium phosphate deposition
6.1 Introduction
6.2 Basicmethods and applications
6.3 Strengths and weaknesses
6.4 Future trends
6.5 Sources of further information and advice
6.6 References
7 Biomaterial surface topography to control cellular response: technologies, cell behaviour and biom
7.1 Introduction
7.2 Defining micron and nano
7.3 Manufacturing surface topography
7.4 Howsurface topography affects cell behaviour
7.5 Technologies and potential applications
7.6 Tissue regeneration
7.7 Current issues and future trends
7.8 Acknowledgements
7.9 References
Part II Analytical techniques and applications
8 Techniques for analysing biomaterial surface chemistry
8.1 Introduction
8.2 X-ray photoelectron spectroscopy (XPS)
8.3 Time of flight secondary ionmass spectrometry (ToF SIMS)
8.4 Sample preparation and handling
8.5 Sources of further information and advice
8.6 Acknowledgements
8.7 References
9 Techniques for analyzing biomaterial surface structure, morphology and topography
9.1 Introduction
9.2 Surface morphology and topography
9.3 Surface structure and spatial distribution
9.4 Energetics
9.5 Future trends
9.6 References
10 Modifying biomaterial surfaces to optimise interactions with blood
10.1 Introduction
10.2 Physicochemical modification
10.3 Biofunctionalisation
10.4 Conclusions
10.5 References
11 Modifying biomaterial surfaces with bioactives to control infection
11.1 Introduction
11.2 Plasma-based strategies for combating device-related infections
11.3 Plasma polymerswith incorporated metal nanoparticles or ions
11.4 Covalent immobilisation of antibacterial molecules
11.5 Future trends
11.6 References
12 Modifying biomaterial surfaces to optimise interactions with soft tissues
12.1 Introduction
12.2 Surface modification of biomaterials for the liver
12.3 Surface modification of biomaterials for the kidney
12.4 Surface modification of biomaterials for tendons/ligaments
12.5 Surface modification of biomaterials for skeletalmuscle
12.6 Surface modification of biomaterials for skin
12.7 Conclusions
12.8 Future trends
12.9 References
13 Modifying biomaterial surfaces for the repair and regeneration of nerve cells
13.1 Introduction: the nervous system
13.2 Surface properties and their effect on neural cells
13.3 Future trends
13.4 References
14 Modifying biomaterial surfaces to control stem cell growth and differentiation
14.1 Introduction
14.2 Surfaces for stemcell expansion
14.3 Surfaces for directing stem cell differentiation
14.4 Surfaces formaintaining the differentiated cell phenotype
14.5 Future trends
14.6 Acknowledgments
14.7 References
15 Modifying biomaterial surfaces to optimise interactions with bone
15.1 Introduction
15.2 Joint replacements: successes and challenges
15.3 Bone graft substitute materials: successes and challenges
15.4 Percutaneous bone-anchored devices
15.5 Summary and conclusions
15.6 Sources of further information and advice
15.7 References
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