Strategies for Reducing Drug and Chemical Residues in Food Animals International Approaches to Residue Avoidance Management and Testing 1st Edition by Ronald E Baynes, Jim E Riviere – Ebook PDF Instant Download/Delivery: 0470247525, 9780470247525
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ISBN 10: 0470247525
ISBN 13: 9780470247525
Author: Ronald E Baynes, Jim E Riviere

Highlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. Focuses attention on drug and chemical residues in edible animal products Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animals Details major drug classes used in food animal production and their residue risks Highlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and Asia, where the issue of chemical exposures has significant impact on livestock products Ties veterinary clinical practice and the use of these drugs in food animals with regulatory standards and mitigation practices

Strategies for Reducing Drug and Chemical Residues in Food Animals International Approaches to Residue Avoidance Management and Testing 1st Table of contents:

1 Importance of Veterinary Drug Residues
1.1 Introduction
1.2 Veterinary Drug Use in Livestock
1.3 Quality Assurance Programs
1.4 Adverse Human Health Effects of Drug Residues
1.5 Withdrawal Time Determinations
1.6 Antimicrobial Resistance
1.7 Economic Impact of Drug Residues
References
2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination of Withdrawal Periods for Animal Drugs
2.1 Introduction
2.2 Basic Pharmacokinetic Principles Underlying Drug Depletion
2.3 The Impact of PK on Drug Depletion
2.4 Factors Influencing ADME
2.5 Conclusion
References
3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals for Establishing Withdrawal Periods and Milk Discard Times
3.1 Introduction
3.2 Information Needed for Determination of Withdrawal Periods or Milk Discard Times
3.3 Factors for Consideration in Conducting a Marker Residue Depletion Study
Acknowledgments
References
4 Establishing Maximum Residue Limits in Europe
4.1 Introduction
4.2 Procedure for the Establishment of MRLs
4.3 Scientific Evaluation
4.4 Extrapolation of MRLs
4.5 Prohibited Drugs
4.6 EU Policy on Minor Use and Minor Species
4.7 EU Policy and Legislation on Feed Additives
4.8 Off-Label Use
Acknowledgments
References
5 Methods to Derive Withdrawal Periods in the European Union
5.1 Introduction
5.2 Withdrawal Periods for Meat
5.3 Statistical Method
5.4 Alternative Approach: Decision Rule
5.5 Withdrawal Periods for Milk
5.6 Withdrawal Periods for Eggs
5.7 Withdrawal Periods for Honey
5.8 Extrapolation of Withdrawal Periods
References
6 Population Pharmacokinetic Modeling to Predict Withdrawal Times
6.1 Introduction
6.2 Applications of Population Modeling to Preslaughter Withdrawal Times
6.3 Covariate Analysis
6.4 Benefits to Population-Based Modeling Techniques
6.5 Limitations of Population-Based Modeling Techniques
6.6 Future Applications
6.7 Conclusions
References
7 Physiologically Based Pharmacokinetic Modeling
7.1 Introduction
7.2 Model Development and Validation
7.3 PBPK Applied to Prediction of Drug Residues
7.4 Conclusions
References
8 Residue Avoidance in Beef Cattle Production Systems
8.1 Introduction
8.2 Beef Cattle Production Systems
8.3 Use of Anti-infective Agents in Beef Cattle Production
8.4 Approaches to Minimize the Need for Antimicrobial Drugs
8.5 Approaches to Minimize the Need for Parasiticides
8.6 Approaches to Minimize Residues (Residue Avoidance)
8.7 Quality Assurance Programs
8.8 The Future: Antimicrobial Regulation and the Market for “Antimicrobial-Free” Beef Products
References
9 Residue Avoidance in Dairy Cattle Production Systems
9.1 Prophylactic Use of Drugs in Dairy Cattle
9.2 Therapeutic Use of Drugs in Dairy Cattle
9.3 Prevalence of Drug Residues
9.4 Minimizing Residues in Meat and Milk
References
10 Residue Avoidance in Aquaculture Production Systems
10.1 Introduction
10.2 Environmental Contaminants
10.3 Drug Use as a Source of Residues
10.4 Melamine Adulteration of Aquaculture Feeds: A Case Study
Acknowledgments
References
11 Residue Avoidance in Small Ruminant Production Systems
11.1 Introduction
11.2 Prophylactic Use of Major Drug Classes (e.g., Antibiotics, Antiparasitics) in Goat and Sheep Production Systems in the EU, United States, and Australasia
11.3 Therapeutic Use of Major Drug Classes (e.g., Antibiotics, Antiparasitics) in Goat and Sheep Production Systems
11.4 Prevalence of Drug Residues in Sheep and Goat Meat and Milk
11.5 Approaches to Minimize Antimicrobial Use and Cost of Eliminating Subtherapeutic Use
11.6 Quality Assurance Programs with Special Emphasis on Management of Drug Residues in Goat and Sheep Production Systems
11.7 The Future
References
12 Residue Avoidance in Swine Production Systems
12.1 Introduction
12.2 Prophylactic Use of Drugs in Swine
12.3 Therapeutic Use of Drugs in Swine
12.4 Prevalence of Drug Residues
12.5 Minimizing Residues in Swine
References
13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities
13.1 Introduction and Essential Concepts
13.2 Instrumentation and Techniques
13.3 Method Development, Validation, and Official Guidelines
13.4 Selected Recent Publications for Confirmation of Veterinary Drugs or Organic Contaminants in Food Animal Products and Feed
13.5 Conclusion and Future Perspective
Acknowledgments
References
14 The Food Animal Residue Avoidance Databank
14.1 Origins of FARAD
14.2 The Role of FARAD
14.3 Access to Regulatory Drug Information via the FARAD Website
14.4 Expert-Mediated Consultations by FARAD
14.5 FARAD Publications and Presentations
14.6 Global FARAD
References
Further Reading
15 Risk Management of Chemical Contaminants in Livestock
15.1 Introduction
15.2 Heptachlor
15.3 Dioxin
15.4 Melamine
15.5 Radioactive Contamination and Management Consideration
15.6 By-Products of Fracking

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Strategies for Reducing Drug and Chemical Residues in Food Animals International Approaches to Residue Avoidance Management and Testing 1st Edition by Ronald E Baynes, Jim E Riviere ISBN 0470247525 9780470247525

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Strategies for Reducing Drug and Chemical Residues in Food Animals International Approaches to Residue Avoidance Management and Testing 1st Edition by Ronald E Baynes, Jim E Riviere ISBN 0470247525 9780470247525

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