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Serotonin and Sleep Molecular Functional and Clinical Aspects 1st Edition by Reidun Ursin, Jaime M Monti, SR Pandi Perumal, Barry L Jacobs, David J Nutt ISBN 3764385618 9783764385613

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Serotonin and Sleep Molecular Functional and Clinical Aspects 1st Edition Reidun Ursin (Auth.) Digital Instant Download

Author(s): Reidun Ursin (auth.), Jaime M. Monti, S. R. Pandi-Perumal, Barry L. Jacobs, David J. Nutt (eds.)
ISBN(s): 9783764385613, 3764385618
Edition: 1
File Details: PDF, 6.79 MB
Year: 2008
Language: english
SKU: EB-4405442 Category: Tags: , , , ,

Serotonin and Sleep Molecular Functional and Clinical Aspects 1st Edition by Reidun Ursin, Jaime M Monti, SR Pandi Perumal, Barry L Jacobs, David J Nutt – Ebook PDF Instant Download/Delivery: 3764385618, 9783764385613
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ISBN 10: 3764385618 
ISBN 13: 9783764385613
Author: Reidun Ursin, Jaime M Monti, SR Pandi Perumal, Barry L Jacobs, David J Nutt

Foreword Barry Jacobs once memorably commented that the problem in understanding the role of serotonin in the brain was that it was implicated in virtually eve- thing but responsible for nothing [1]. Serotonin (5-HT) is defnitely implicated in the regulation of sleep but what does it do? Once seen as a sleep-promoting molecule, Jacob’s own work, lucidly described in this volume, radically changed our view. In fact, serotonin neurons are most active during waking; their – tivity diminishes with sleep onset and disappears during rapid eye movement (REM) sleep. Serotonin, therefore, is intimately linked to the sleep-wake cycle, but what is its role, what mechanisms are involved and what are the impli- tions for sleep medicine and psychiatry? Making progress with these diffcult questions requires a “translational” approach, which is a research paradigm where both laboratory and clinical neuroscience inform and guide each other with the ultimate aim of improving understanding and treatment of medical conditions. This volume is a superb example of translational research, where leading basic and clinical scientists – tegrate molecular, neuropharmacological and systems approaches to illuminate the reciprocal interactions of serotonin neurons and the mechanisms involved in sleep and circadian regulation. Serotonin is an ancient chemical mediator preserved through at least 500 m- lion years of evolution. In invertebrate animals such as mollusks and leeches, 5-HT cells are distributed throughout the nervous system among the various ganglia.

Serotonin and Sleep Molecular Functional and Clinical Aspects 1st Table of contents:

Chapter 1 – Introduction to Serotonin

Discovery and Overview of Serotonin

Serotonin’s Role in the Brain and Body

Synthesis and Metabolism of Serotonin

Serotonin Receptors and Their Functions

Chapter 2 – The Biology of Sleep

The Sleep Cycle: NREM and REM Sleep

Neural Mechanisms of Sleep Regulation

The Role of the Brainstem, Hypothalamus, and Thalamus

Circadian Rhythms and Sleep-Wake Regulation

Chapter 3 – Serotonin and the Sleep-Wake Cycle

Serotonin’s Role in Sleep Onset and Maintenance

Interaction Between Serotonin and Other Neurotransmitters

Serotonin’s Modulation of Sleep Architecture

Molecular Mechanisms: Serotonin Receptors and Sleep Regulation

Chapter 4 – Serotonin and Sleep Disorders

Serotonin Deficiency and Its Role in Insomnia

Serotonergic Dysfunction in Sleep Apnea and Narcolepsy

Serotonin and Restless Leg Syndrome (RLS)

The Impact of Serotonin on REM Sleep Behavior Disorder

Chapter 5 – Pharmacology of Serotonin in Sleep Regulation

Serotoninergic Drugs and Their Effects on Sleep

Serotonin Reuptake Inhibitors (SSRIs) and Sleep Patterns

Melatonin and Serotonin Interaction

Other Pharmacological Agents Affecting Serotonin and Sleep

Chapter 6 – Clinical Aspects of Serotonin and Sleep Disorders

Diagnosis of Sleep Disorders Involving Serotonin Dysfunction

Clinical Approaches to Treating Serotonergic Sleep Disorders

Use of Serotonergic Drugs in Sleep Medicine

Case Studies: Clinical Interventions and Outcomes

Chapter 7 – Serotonin and Sleep in Health and Disease

Serotonin’s Role in Healthy Sleep Patterns

Altered Serotonergic Systems in Neuropsychiatric Disorders

The Relationship Between Sleep and Psychiatric Conditions (Depression, Anxiety, etc.)

Aging and Serotonin’s Effect on Sleep in Older Adults

Chapter 8 – Experimental Approaches in Serotonin and Sleep Research

Animal Models of Serotonin and Sleep

Neuroimaging Techniques to Study Serotonin and Sleep

Genetic Approaches in Serotonin Sleep Regulation

Experimental Pharmacology in Sleep Studies

Chapter 9 – Future Directions in Serotonin and Sleep Research

Advances in Understanding the Molecular Mechanisms

Novel Therapeutic Approaches for Sleep Disorders

The Role of Genetics in Sleep Regulation

Integrating Serotonin Research with Broader Sleep Medicine

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Tags: Reidun Ursin, Jaime M Monti, SR Pandi Perumal, Barry L Jacobs, David J Nutt, Serotonin, Molecular Functional, Clinical Aspects