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Salivary Glands Development Adaptations and Disease 1st Edition by Abigail S Tucker, Isabelle Miletich ISBN 3805594062 9783805594066

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Salivary Glands Abigail S. Tucker Digital Instant Download

Author(s): Abigail S. Tucker, Isabelle Miletich
ISBN(s): 9783805594066, 3805594062
Edition: Kindle
File Details: PDF, 3.19 MB
Year: 2010
Language: english
SKU: EB-1974102 Category: Tags: ,

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Product details:

ISBN 10: 3805594062 
ISBN 13: 9783805594066
Author: Abigail S Tucker, Isabelle Miletich

Salivary glands are of utmost importance for several physiological functions ranging from the protection of teeth and surrounding soft tissues to the lubrication of the oral cavity, which is crucial for speech and perception of food taste. This publication highlights specific aspects of salivary gland development, investigating the mechanisms involved in embryonic development, the current research in stem cells, the ability of adult glands to regenerate and the signalling pathways involved in this process. Key stages of salivary gland development, moving from initiation to differentiation of the glands, are discussed, as well as unusual adaptations, ranging from making silk to making venom. The book finally provides new data on surgical techniques and diagnostic tools for clinicians involved in salivary gland disorders. Researchers and students with an interest in craniofacial sciences as well as clinicians dealing with salivary gland disorders will find this publication an excellent source of up-to-date information.

Salivary Glands Development Adaptations and Disease 1st Table of contents:

Introduction to Salivary Glands: Structure, Function and Embryonic Development
Abstract
Salivary Glands as Multifunctional Organs
Structures and Cell Types of Adult Salivary Glands
Different Salivary Glands, in Different Locations
Control of Saliva Production
The Mouse Submandibular Gland as a Model for Vertebrate Salivary Gland Development
Early Embryonic Development of Salivary Glands: Initial Bud Formation
Forming Branches to Escape Space Constraints
Turning Solid Epithelial Chords into Hollow Tubes
Conclusions and Perspectives
Rerefrences
Salivary Gland Adaptations: Modification of the Glands for Novel Uses
Abstract
Silk Production
Nest Formation
Venom Production
Venomous Saliva in Mammals
Evolution of the Venom System in Reptiles
Interactions of Glands and Teeth in the Reptilian Venom System
Conclusions
Acknowledgement
Rerefrences
Genetic Regulation of Salivary Gland Development in Drosophila melanogaster
Abstract
Salivary Gland Invagination
Salivary Gland Lumen Elongation
Salivary Gland Migration
Axon Guidance Cues in Salivary Gland Migration
Salivary Gland Mutagenesis Screens
Conclusion
Rerefrences
Extracellular Matrix and Growth Factors in Salivary Gland Development
Abstract
Three-Dimensional Cell and Tissue Models
Collagen
Laminin
Nidogen
Epimorphin
Tenascin C
Proteoglycans
Fibronectin
Integrins
Non-Integrin ECM Receptors
Growth Factor Signaling
Proteases and Protease Inhibitors
Exogenous Matrices and Tissue Engineering
ECM Alterations in Sjögren‘s Syndrome
ECM in Salivary Neoplasms
Future Directions
Acknowledgements
Rerefrences
Lumen Formation in Salivary Gland Development
Abstract
The Histology of Lumen Formation
Creating a Space
Lining the Lumen: Cell-Cell Junctions
Tight Junctions
Adherens Junctions
Apicobasal Polarity
Future Research
Rerefrences
Epithelial Stem/Progenitor Cells in the Embryonic Mouse Submandibular Gland
Abstract
Adult Salivary Gland Stem/Progenitor Cells
Embryonic Salivary Gland Stem/Progenitor Cells
SMG Expresses TFs Involved in Embryonic Stem Cell Self-Renewal
ETS and Sox-Related Transcription Factors are Expressed in the Epithelial End Bud
SMG Epithelia Contain Basal Progenitor Cells
Influence of Mesenchyme-Produced Growth Factors on Progenitor Cell Fate Decisions
Different ES-Related Maintenance Genes Are Downregulated by FGFs
FGF7 and FGF10 Control Bud-Related Maintenance/Differentiation Genes
Basal Cells Are Regulated by TGF-βs
Conclusion
Rerefrences
Salivary Gland Regeneration
Abstract
Clinical Need
Salivary Glands Are Highly Adaptable
Animal Models of Glandular Atrophy and Regeneration
Mechanisms of Maintaining Gland Size
Evidence for Regeneration following an Embryonic-Like Pathway
The Bioinformatics Approach to Studying Signalling Pathways in Regenerating Glands
MAPKs Signalling Pathway
Notch Signalling Pathway
Wnt Signalling Pathway
Stem Cell Therapies to Regenerate Salivary Glands
Bioengineering of Salivary Glands
Conclusions
Acknowledgements
Rerefrences
Salivary Gland Disease
Abstract
Salivary Gland Obstructive Disease
Salivary Gland Calculi
Treatment Modalities for Stone Removal
Management of Strictures
Tumours of the Salivary Glands
Incidence
Distribution by Site of Benign and Malignant Salivary Gland Tumours
Histological Tumour Types
Management
Sjögren’s Syndrome

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Tags: Abigail S Tucker, Isabelle Miletich, Salivary Glands