RNA Viruses Host Gene Responses to Infections 1st Edition by Decheng Yang ISBN 981283379X 9789812833792

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ISBN 10: 981283379X 
ISBN 13: 9789812833792
Author: Decheng Yang

This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others.

In this text human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.

Organized into 27 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host–virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.

RNA Viruses Host Gene Responses to Infections 1st Table of contents:

• Mechanisms of RNA Virus Invasion

  • Virus entry and replication processes
  • Host cell recognition by viral proteins
  • Viral genome replication

• Host Gene Responses to RNA Virus Infections

  • Immune system activation
  • Transcriptional and translational responses
  • Cytokine production and signaling pathways

• RNA Interference and Host Defenses

  • Role of RNA interference in host defense
  • Viral countermeasures against RNA interference

• Host-Pathogen Interactions

  • Host immune evasion strategies
  • Interactions between viral proteins and host cell machinery

• Impact of RNA Virus Infections on Host Gene Expression

  • Changes in host gene expression during infection
  • Molecular pathways affected by viral replication

• Host Cellular Responses to Viral Stress

  • Stress responses in infected cells
  • Autophagy and apoptosis in RNA virus infections

• Impact of Viral Infections on Host Transcriptome

  • High-throughput sequencing and analysis
  • Differential gene expression during infections

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Decheng Yang,RNA Viruses,Host Gene