Reflections on a Century of Malaria Biochemistry Reflections on a Century of Malaria Biochemistry 1st Edition by Irwin W Sherman ISBN 0123743397 9780123743398

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ISBN 10: 0123743397 
ISBN 13: 9780123743398
Author: Irwin W Sherman

Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa.

This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.

* Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field
Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria

* Chronicles both biochemical successes and failures
Benefit: Allows researchers to see what has and hasn’t work which they can then apply in their own research

Reflections on a Century of Malaria Biochemistry Reflections on a Century of Malaria Biochemistry 1st Table of contents:

Chapter 1: Introduction
Chapter 2: An Introduction to Malaria Parasites
Chapter 3: The Early Years
Chapter 4: Show Me the Money
Chapter 5: In Vivo and In Vitro Models
1. Life in the Erythrocyte
2. Life Outside the Erythrocyte
3. Life in the Mosquito
Chapter 6: Malaria Pigment
Chapter 7: Chloroquine and Hemozoin
Chapter 8: Isoenzymes
Chapter 9: The Road to the Plasmodium falciparum Genome
Chapter 10: Carbohydrate Metabolism
1. Glycolysis and the Tricarboxylic Acid Cycle
2. The Pentose Phosphate Pathway
3. Pyridine Nucleotides
4. Carbon Dioxide Fixation
Chapter 11: Pyrimidines and the Mitochondrion
Chapter 12: The Road to Atovaquone
Chapter 13: The Ring Road to the Apicoplast
Chapter 14: Ribosomes and Ribosomal Ribonucleic Acid Synthesis
Chapter 15: De Novo Synthesis of Pyrimidines and Folates
Chapter 16: Salvage of Purines
Chapter 17: Polyamines
Chapter 18: New Permeability Pathways and Transport
Chapter 19: Hemoglobinases
Chapter 20: Erythrocyte Surface Membrane Proteins
1. The Road to PfEMP1
2. PfEMP1, Knobs and Adhesion
3. PfEMP1 and Rosetting
4. PfEMP1 and Placental Adhesion
5. Knob-Associated Proteins Involved with Adhesion
6. Band 3 and Adhesion
7. Adhesion and Cerebral Malaria
Chapter 21: Trafficking
Chapter 22: Erythrocyte Membrane Lipids
Chapter 23: Invasion of Erythrocytes
Chapter 24: Vitamins and Anti-Oxidant Defenses
1. Vitamin B1 (Thiamin)
2. Vitamin B6
3. Pantothenate
4. Biotin (Vitamin B7)
5. Vitamin B3 (Niacin)
6. P-Aminobenzoic Acid
7. Riboflavin
8. Vitamins A, C, D and E
9. Anti-Oxidant Defenses
Chapter 25: Shocks and Clocks
Chapter 26: Transcriptomes, Proteomes and Data Mining
1. Transcriptomes
2. Proteomes
3. Data Mining
Chapter 27: Mosquito Interactions
1. Sexual Stages in the Blood
2. Gametogenesis and Ookinete Formation
3. Oocyst and Sporozoite Formation
4. Journey to the Liver

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