Rapid Eye Movement Sleep Regulation and Function 1st Edition by Carlos Schenck, Birgit Hogl, Aleksandar Videnovic ISBN 3319901524 9783319901527

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ISBN 10: 3319901524 
ISBN 13: 9783319901527
Author: Carlos H. Schenck, Birgit Högl, Aleksandar Videnovic

This book describes a sleep disorder belonging to the category of parasomnias (i.e. the sleep behavioral and experiential disorders) characterized by abnormal vocal and motor behaviors in the context of vivid dreams and loss of the customary muscle atonia during the stage of sleep called REM sleep. REM-atonia – one of the defining features of REM sleep, along with rapid-eye-movements and a highly activated brain state – serves a protective function, preventing the dreamer from acting-out dreams and becoming injured. REM sleep behavior disorder (RBD) was first described in 1986 by Schenck and colleagues; since then the understanding of the condition has increased exponentially, also pointing out its strong association with the development of neurodegenerative disorders characterized by alpha synuclein deposition, such as Parkinson’s disease, Dementia with Lewy bodies, and Multiple System Atrophy. Furthermore, RBD is now considered one of the earliest markers of ongoing alpha synuclein neurodegeneration, and provides a window of opportunity for testing disease modifying therapies that may slow down or halt the progression of these disorders for which there is currently no cure.

Additionally, RBD is today known to be present in more than 50% of patients with narcolepsy-cataplexy, and can also be triggered by the most commonly prescribed antidepressant medications (e.g. SSRIs, venlafaxine). RBD has been documented as occurring, with variable frequency, with virtually every category of neurologic disease and has also helped expand the field of dream research.

The volume Editors have pioneered scientific and clinical advances in the field and, partnering with leading sleep clinicians and researchers on this book, have produced an invaluable guide to specialists in sleep medicine, neurology, psychiatry and psychology. There are also strong contributions in this book by leading basic science researchers, and so this book should also appeal to neuroscientists. As stated in the book, “RBD is situated at a strategic and busy crossroads of sleep medicine and the neurosciences. RBD offers great breadth and depth of research opportunities, including extensive inter-disciplinary and multinational research opportunities…RBD is an ‘experiment of Nature’ in which knowledge from the study of motor-behavioral dyscontrol during REM sleep, with dream-enactment, has cast a broad and powerful light on a multitude of Central Nervous System disturbances, their evolution, and their comorbidities.”

Rapid Eye Movement Sleep Regulation and Function 1st Table of contents:

Part I. Introduction
1. RBD: Historical Perspective
2. The Human Dimension of RBD
3. The Foundation of the International RBD Study Group (IRBDSG)
Part II. RBD: Clinical Spectrum
4. Clinical Aspects of Idiopathic RBD
5. REM Sleep Behavior Disorder Associated with Parkinson’s Disease and Multiple System Atrophy
6. REM Sleep Behavior Disorder Associated with Dementia with Lewy Bodies
7. RBD and Non-synuclein Neurodegenerative Disorders: A Critical Appraisal
8. RBD Associated with Paraneoplastic Neurological Syndromes and Autoimmune Disorders
9. Lesional RBD
10. RBD, Antidepressant Medications, and Psychiatric Disorders
11. REM Sleep Behavior Disorder in Narcolepsy
12. Acute REM Sleep Behavior Disorder
13. Physiological Substrates of RBD Subtypes
14. RBD in Childhood and Adolescence
15. RBD in Adults Under 50 Years Old
16. RBD: Gender Implications
17. RBD: A Window into the Dreaming Process
Part III. Diagnosis and Treatment
18. Diagnosis of REM Sleep Behavior Disorder
19. Instruments for Screening, Diagnosis and Assessment of RBD Severity and Monitoring Treatment Outcome
20. Selective Polysomnographic Findings in REM Sleep Behavior Disorder (RBD) and Parkinson’s Disease
21. Video Analysis of Behaviors and Movements in RBD
22. Clinical Vignettes: Illustrative, Unusual, and Challenging RBD Cases
23. Management of a Patient with RBD
24. Melatonin Therapy of RBD
25. Clonazepam and Other Therapies of RBD
26. Differential Diagnosis and Related Disorders: RBD Mimics
27. Parasomnia Overlap Disorder: RBD and NREM Parasomnias
28. Status Dissociatus and Its Relation to RBD
Part IV. Clinical Research and Issues in RBD
29. Local Cortical Activations During REM Sleep and Implications for RBD
30. Brain Imaging in RBD
31. The Electromyographic Diagnosis of REM Sleep Without Atonia and REM Sleep Behavior Disorder
32. RBD and the Autonomic Nervous System
33. Cardiac Scintigraphy in RBD
34. Neuropsychological Aspects: Cognition in RBD
35. Neuropsychological Aspects: Impulse-Control Disorders and Other Neuropsychiatric Features in RBD
36. Biomarkers of Neurodegenerative Disease in Idiopathic RBD
37. RBD, Gastric Peptides, and Gastric Motility
38. Gait and Postural Disorders in REM Sleep Behavior Disorder
Part V. RBD: Basic Science
39. Neural Circuitry Regulating REM Sleep and Its Implication in REM Sleep Behavior Disorder
40. Neuropathology of REM Sleep Behavior Disorder
41. Genetics of REM Sleep Behavior Disorder
42. Animal Models of REM Sleep Behavior Disorder
43. REM Sleep Behavior Disorder: The Link Between Synucleinopathies and REM Sleep Circuits
Part VI. Challenges and Opportunities
44. Toward Disease Modification Trials in RBD: Challenges and Opportunities
45. RBD: Future Directions in Research and Clinical Care and Counseling

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