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Radiotherapy Treatment Planning Linear Quadratic Radiobiology 1st Edition by J Donald Chapman, Alan E Nahum ISBN 1439862591 9781439862599

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Radiotherapy Treatment Planning Linear Quadratic Radiobiology 1st Edition J. Donald Chapman Digital Instant Download

Author(s): J. Donald Chapman, Alan E. Nahum
ISBN(s): 9781439862599, 1439862591
Edition: 1
File Details: PDF, 3.05 MB
Year: 2015
Language: english
SKU: EB-5086750 Category: Tags: ,

Radiotherapy Treatment Planning Linear Quadratic Radiobiology 1st Edition by J Donald Chapman, Alan E Nahum – Ebook PDF Instant Download/Delivery: 1439862591, 9781439862599
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ISBN 10: 1439862591 
ISBN 13: 9781439862599
Author: J Donald Chapman, Alan E Nahum

Understand Quantitative Radiobiology from a Radiation Biophysics PerspectiveIn the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and of

Radiotherapy Treatment Planning Linear Quadratic Radiobiology 1st Table of contents:

1. Introduction

  • General background on radiobiology, possibly introducing key concepts like radiation types, biological impact, and the clinical relevance to oncology.

2. The Generation of Quantitative Radiobiology Data

  • How radiobiology data is gathered, possibly focusing on experimental methods, cell lines, and mathematical models used.

3. Intrinsic Radiosensitivity of Proliferating and Quiescent Cells

  • Differences between how actively dividing cells (proliferating) and non-dividing cells (quiescent) respond to radiation.

4. Effects of Ionization Density and Volume

  • 4.1 Ionizations along Charged-Particle Tracks: Discussing how ionizing radiation interacts with biological tissue along particle tracks.

  • 4.2 The ABCs of Charged-Particle Radiotherapy: Fundamentals of charged-particle therapy (e.g., protons, carbon ions).

  • 4.3 The Frequency of Electron Track-Ends in Radiation Dose: Exploration of electron energy and track ends in dose distribution.

5. Impact of Fraction Size, Dose-Rate, Temperature and Overall Treatment Time on Tumor Cell Response

  • Examining how variations in treatment parameters influence tumor cell responses to radiation.

6. Ionizing Events, Molecular Targets, and Lethal Lesions

  • 6.1 Time-Scale of Radiation-Induced Cellular Damages and Their Expression: Understanding the timing and progression of radiation-induced damage.

  • 6.2 The Oxygen Effect and Oxygen Enhancement Ratio (OER): Discussing how oxygen affects radiation damage and the OER.

  • 6.3 Radiation Events—The Role of Energy Density and Ionization Volume: Insights into how radiation energy and dose volume influence outcomes.

  • 6.4 The Molecular Target(s) for Cell Inactivation: Identifying molecular targets (e.g., DNA, cell membrane).

  • 6.5 Lesions Produced in Cellular DNA by Radiation: Types of DNA damage caused by radiation and its consequences.

7. The Radiosensitivity of Tumor Cells In Vitro versus In Vivo

  • 7.1 The Radiosensitivity of Cells Irradiated in Multicellular Spheroids: Studying radiation response in 3D models.

  • 7.2 The Radiosensitivity of Rodent Tumor Cells: How rodent models are used for radiation research.

  • 7.3 Appropriate Inactivation Parameters for Modeling Human Tumor Response: Translating animal model data to human tumor behavior.

8. Modern Radiobiology and the LQ Equation

  • 8.1 Molecular Biology Factors of α- and β-Inactivation: Understanding the LQ (Linear-Quadratic) model parameters for radiation dose-response.

  • 8.2 Low Dose Hypersensitivity (LDH): Investigating the paradox of cells being more sensitive at low doses.

  • 8.3 Bystander Effects: Studying how non-irradiated cells can be affected by radiation through signaling.

9. Normal Tissue Radiobiology

  • 9.1 Information Derived from In Vitro Studies of Normal Tissue Cell Lines: Radiobiological data from normal tissue models.

  • 9.2 Therapeutic Ratio: Balancing tumor control and normal tissue damage.

  • 9.3 Fractionation: The impact of dose fractionation on normal tissue and tumor response.

  • 9.4 Functional Subunits (FSUs) and the Volume Effect: Concept of FSUs and the volume effect in normal tissue response.

  • 9.5 A Summary of the QUANTEC Study: Overview of QUANTEC recommendations on normal tissue tolerance doses.

10. Radiobiology Applied to Tumor Response Modeling

  • 10.1 Surviving Fractions after Fractionated Dose Delivery: Modeling survival fractions in fractionated radiation therapy.

  • 10.5 Future Perspectives: Speculating on advancements in radiobiology and therapy (e.g., personalized radiotherapy).

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Tags: J Donald Chapman, Alan E Nahum, Quadratic Radiobiology