Sale!

Principles of stem cell biology and cancer future applications and therapeutics 1st Edition by Tarik Regad, Thomas Sayers, Robert Rees ISBN 1118670620 9781691932139

Original price was: $50.00.Current price is: $35.00.

Principles of stem cell biology and cancer future applications and therapeutics 1st Edition Robert C. Rees Digital Instant Download

Author(s): Robert C. Rees, TarikRegad, Thomas Sayers, (eds.)
ISBN(s): 9781691932139, 1118670620
Edition: 1
File Details: PDF, 7.05 MB
Year: 2015
Language: english
SKU: EB-5310972 Category: Tags: , , ,

Principles of stem cell biology and cancer future applications and therapeutics 1st Edition by Tarik Regad, Thomas Sayers, Robert Rees – Ebook PDF Instant Download/Delivery: 1118670620, 9781691932139
Full download Principles of stem cell biology and cancer future applications and therapeutics 1st Edition after payment

Product details:

ISBN 10: 1118670620 
ISBN 13: 9781691932139
Author: Tarik Regad, Thomas Sayers, Robert Rees

Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Principles of stem cell biology and cancer future applications and therapeutics 1st Table of contents:

Part I: Stem Cells
Chapter 1: Isolation and Characterization of Human Embryonic Stem Cells and Future Applications in Tissue Engineering Therapies
1.1 Derivation of human embryonic stem cells from the ICM
1.2 Basic characterization of hESCs
1.3 Stem cell quality and culture adaptation with reference to cancer
1.4 Future applications in tissue-engineering therapies
1.5 Conclusions
References
Chapter 2: Epigenetics, Stem Cell Pluripotency and Differentiation
2.1 Introduction
2.2 Epigenetic regulation of the pluripotent state
2.3 Epigenetic changes during differentiation
2.4 Reprogramming of somatic cells to pluripotency: reversing the epigenetic landscape
2.5 Epigenetics, stem cells and cancer
2.6 Conclusions
Acknowledgements
References
Chapter 3: Stem Cell Niche and Microenvironment
3.1 Concept of the stem cell niche
3.2 Organization of the niche
3.3 Relationship between niche and stem cells
3.4 Instructive niche effect
3.5 Cancer stem cell niche
3.6 Conclusions
References
Chapter 4: Haematopoietic Stem Cells in Therapy
4.1 Introduction
4.2 Established clinical use of HSCs: common indications of HSCT in children
4.4 Conclusions
References
Chapter 5: Isolation and Identification of Neural Stem/Progenitor Cells
5.1 Introduction
5.2 Stem cell concept
5.3 Neural stem cells
5.4 The neurosphere assay: a gold-standard assay
5.5 Limitations of the NSA
5.6 The neural colony-forming cell assay: enumeration of actual NSCs
5.7 Purification strategies: the quest for a cellular identity
5.8 Conclusions
References
Part II: Cancer Stem Cells
Chapter 6: The Role of Epithelial– Mesenchymal Transition in Cancer Metastasis
6.1 Introduction
6.2 Fundamental components of the cellular and molecular programme of EMT in cancer
6.3 The role of EMT in metastasis
6.4 Epithelial–mesenchymal plasticity
6.5 Association between EMT and CSCs
6.6 Role of hypoxia in the induction of EMT and in supporting metastasis of cells that have undergone EMT
6.7 EMT and resistance to cancer treatment
6.8 Conclusions
References
Chapter 7: Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in the Metastatic Niche
7.1 Introduction
7.2 Tumour microenvironment and CSCs
7.3 Isolation and identification of MSCs
7.4 Plasticity and the differentiation potential of MSCs
7.5 The role of MSCs in breast cancer
7.6 Induction of EMT and expansion of breast CSCs by MSCs
7.7 EMT and MET CSC plasticity in migration and metastasis
7.8 Signalling crosstalk between MSCs and breast CSCs
7.9 Conclusions
References
Chapter 8: Isolation and Identification of Neural Cancer Stem/Progenitor Cells
8.1 Definition of a neural stem cell: functional and marker-based
8.2 Cancer stem cell hypothesis
8.3 Identification of neural CSCs
8.4 Identification of BTICs
8.5 Current CSC markers
8.6 Isolation of neural CSCs
8.7 Role of the microenvironment in tumour progression
8.8 Epigenetic mechanisms of BTIC regulation
8.9 The therapeutic utility of identifying BTICs
References
Chapter 9: Colon Stem Cells in Colorectal Cancer
9.1 Background
9.2 CRCSCs
9.3 Conclusions
Acknowledgements
References
Chapter 10: Prostate Cancer and Prostate Cancer Stem Cells
10.1 Development and origin of the prostate
10.2 Adult prostate stem cells
10.3 Prostate cancer and prostate cancer stem cells
10.4 Conclusions
References
Chapter 11: Stem Cells and Pancreatic Cancer
11.1 Introduction
11.2 Pancreas
11.3 In search of a cell of origin: mouse models of pancreatic cancer
11.4 Current methods of detection
11.5 Markers
11.6 Signalling pathways mediating PCSCs
11.7 Therapeutics (future directions)
References
Chapter 12: NANOG in Cancer Development
12.1 Introduction
12.2 The function of NANOG in ESCs
12.3 NANOG and cancer development
12.4 NANOG1 versus NANOGP8 in cancer development
12.5 Evidence for the unique biochemical properties of NANOG protein
12.6 Conclusions
Acknowledgments
References
Chapter 13: Liver Cancer Stem Cells and Hepatocarcinogenesis
13.1 Introduction
13.2 Liver progenitor cells and their function
13.3 Cancer stem cells and their functional aspects
13.4 Future perspectives
References
Chapter 14: Basic Science of Liver Cancer Stem Cells and Hepatocarcinogenesis
14.1 Introduction
14.2 Experimental evidence of LCSCs
14.3 Conclusions
References
Chapter 15: Cancer Stem Cell Biomarkers
15.1 Cancer stem cells
15.2 Choice of CSC biomarkers
15.3 Imperfect markers
15.4 Conclusions
References
Chapter 16: Interactomic Analysis of the Stem Cell Marker NANOG in a Prostate Cancer Setting
16.1 Introduction
16.2 Methodological background
16.3 Results and development of networks
16.4 Discussion

People also search for Principles of stem cell biology and cancer future applications and therapeutics 1st:

    
principles of cancer biology kleinsmith pdf
    
principles of cancer genetics
    
principles of biosciences
    
principles of stem cell biology and cancer
    
applying the principles of stem-cell biology to cancer

Tags:

Tarik Regad,Thomas Sayers,Robert Rees,Principles,cell biology,cancer