Principles of Bacterial Pathogenesis 1st Edition by Eduardo A Groisman ISBN 0123042208 9780123042200

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ISBN 10: 0123042208 
ISBN 13: 9780123042200
Author: Eduardo A Groisman

Principles of Bacterial Pathogenesis 1st Table of contents:

Chapter 1: Evolution of Bacterial Pathogens
I. Introduction
II. The Genetic Basis of Virulence
III. Identification of Sequences Involved in Bacterial Pathogenesis
IV. Recovery of Genes Contributing to Virulence
V. The Population Genetics of Pathogens
VI. Studying Bacterial Population Genetics
VII. The Organization of Genetic Diversity in Pathogenic Microorganisms
VIII. Population Genetics of Representative Bacterial Pathogens
IX. Conclusions

Chapter 2: Germ Warfare: The Mechanisms of Virulence Factor Delivery
I. Introduction
II. The General Secretory Pathway
III. Autotransporters: Type V
IV. Two-Step Secretion: Type II
V. ABC Transporters: Type I
VI. Conjugal Transfer Systems: Type IV
VII. Contact-Dependent Secretion: Type III
VIII. Concluding Remarks

Chapter 3: Regulation of Virulence Gene Expression in Bacterial Pathogens
I. Introduction
II. Transcription Initiation
III. Regulatory Protein Families
IV. Covalent Modification of Transcription Factors
V. Regulatory Networks
VI. The Oxidative Stress Response
VII. The Modular Nature of Bacterial Regulatory Proteins
VIII. The Overlap between Genome Structure and Gene Regulation
IX. Other Classes of Protein Regulators
X. DNA Structure and Gene Regulation
XI. Stereotypical and Stochastic Events in the Control of Gene Expression
XII. The Switch Controlling Type 1 Fimbrial Expression in E. coli
XIII. Pap Pilus Gene Transcription
XIV. Contact-Dependent Gene Regulation
XV. The Virulence Gene Regulatory Cascade of S. flexneri
XVI. A Thermometer Protein from the Salmonella Virulence Plasmid
XVII. Cell-Density-Dependent Regulation
XVIII. Adaptive Mutation
XIX. Rare tRNAs and Translation Modulation
XX. Protein Splicing
XXI. Antisense RNA
XXII. Perspective
Acknowledgments

Chapter 4: Strategies to Identify Bacterial Pathogenicity Factors
I. Introduction
II. Biochemical Strategies
III. Genetic Screens
IV. Genetic Selections
V. Genomic Approaches
VI. Concluding Remarks

Chapter 5: Mechanisms of Bacterial Pathogenesis in Plants: Familiar Foes in a Foreign Kingdom
I. Introduction
II. An Overview of Bacterial Plant Pathogens and Plant Diseases
III. Tumorigenic Agrobacterium tumefaciens: Using the Type IV Secretion System to Transform the Host into a Factory for Bacterial Nutrients
IV. Necrogenic, Stealth Pathogens: Parasites Strongly Dependent on the Hrp (Type III) Protein Secretion System
V. Necrogenic, Brute-Force Pathogens: Soft-Rotters Dependent on Type II Secretion of Pectic Enzymes
VI. Other Virulence Factors of Gram-Negative Plant Pathogens Compared with Those of Animal Pathogens
VII. Host Innate Immune Systems: Common Components in Pathogen Recognition and Defense Signaling
VIII. The R Gene Surveillance System: An Innate Immune System with Elaborate Recognition Specificity
IX. Pseudomonas aeruginosa: Dual-Kingdom Pathogenesis
X. Conclusions
Acknowledgments

Chapter 6: Yersinia
I. Introduction
II. The Adhesive Factors
III. Iron Acquisition
IV. Pathogenicity Islands
V. Yst Enterotoxin
VI. The Yersinia Virulence Plasmid
VII. Conclusion
Acknowledgments

Chapter 7: Molecular Pathogenesis of Salmonellae
I. Introduction
II. History
III. Taxonomy
IV. Epidemiology and Clinical Disease
V. Clinical Course and Basic Immunology
VI. In Vitro Models of Salmonella Virulence
VII. Virulence Factors
VIII. Antibiotic-Resistant Salmonellae
IX. Salmonella-Based Vaccines
Acknowledgments

Chapter 8: Shigellosis: From Disease Symptoms to Molecular and Cellular Pathogenesis
I. Introduction
II. Bacteriology
III. The Somatic Antigen
IV. Epidemiology and Transmission
V. Disease Symptoms and Complications: Orientations for Future Research?
VI. Histopathology of Shigellosis: A Window on Pathogenesis
VII. Animal Models: Strengths and Weaknesses
VIII. Cellular Models of Infection: The Contribution of Shigella to the Concept of Cellular Microbiology
IX. Pathogenic Mechanisms: In Vitro Expression of the Invasive Phenotype
X. Pathogenic Mechanisms: In Vivo Expression of the Invasive Phenotype
XI. Role of Chromosomally Encoded Genes in the Virulence of Shigella
XII. Conclusions
Acknowledgments

Chapter 9: Pathogenic Escherichia coli
I. Introduction
II. Enterotoxigenic E. coli (ETEC)
III. Enteroinvasive E. coli (EIEC)
IV. Enteropathogenic Escherichia coli (EPEC)
V. Enterohemorrhagic E. coli (EHEC)
VI. Enteroaggregative E. coli (EAEC)
VII. Diffusely Adhering E. coli (DAEC)
VIII. Uropathogenic E. coli
IX. E. coli That Cause Sepsis and Meningitis
X. Conclusions

Chapter 10: Molecular Basis of Vibrio cholerae Pathogenesis
I. Introduction
II. Vibrio cholerae
III. Cholera
IV. Molecular Mechanisms of Disease
V. Natural and Induced Immunity against Vibrio cholerae Infection
VI. Future Studies: The Past Is Prologue
Acknowledgments

Chapter 11: H. pylori Pathogenesis
I. Introduction
II. Epidemiology
III. Gastric Histology and Physiology
IV. Clinical Diseases Associated with H. pylori Infection
V. Microbiology
VI. Genetic Diversity and Population Structure of H. pylori
VII. Initial Gastric Colonization
VIII. Gastric Inflammation
IX. Interactions of H. pylori with the Gastric Epithelium
X. Vacuolating Cytotoxin
XI. Persistence of H. pylori Infection
XII. Factors Influencing Development of Clinically Evident Disease
Acknowledgments

Chapter 12: Neisseria
I. Introduction
II. Natural Competence for Transformation
III. Surface Structures
IV. Tissue Colonization
V. PorB
VI. IgA1 Protease
VII. Iron Acquisition in Vivo
VIII. Immune Response
IX. Summary

Chapter 13: Bordetella
I. Introduction
II. Respiratory Infections by Bordetella Species
III. Evolutionary Relationships among Bordetella Subspecies
IV. Bordetella Virulence Factors
I. The Bordetella Type III Secretion System
V. The Bordetella–Host Interaction
VI. The BvgAS Sensory Transduction System
VII. Phenotypic Modulation
VIII. Transcriptional Control of Bvg-Regulated Genes
IX. The Role of Bvg-Mediated Signal Transduction in the Bordetella Life Cycle
Acknowledgments

Chapter 14: Pathogenesis of Haemophilus influenzae Infections
I. Introduction
II. Population Biology
III. Molecular Determinants of Pathogenicity
IV. Pathogenesis
V. Conclusions

Chapter 15: Pathogenic Mechanisms in Streptococcal Diseases
I. Introduction
II. Three Basic Mechanisms of Pathogenesis: Example of S. pyogenes
III. Steps Common to All Three Pathogenic Mechanisms
IV. First Mechanism: Invasion and Multiplication in Tissue
V. Second Mechanism: Toxin-Mediated Disease
VI. Third Mechanism: Immunopathological-Based Diseases
VII. Concluding Remarks

Chapter 16: Listeria monocytogenes
I. General Overview of Listeria monocytogenes and Listeriosis
II. Genetic Tools and Cell Biology Techniques to Study L. monocytogenes Infection
III. Molecular Mechanisms for Entry and Spread of L. monocytogenes in Nonphagocytic Cells
IV. Regulation of L. monocytogenes Virulence Gene Expression
V. Conclusion

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