Plasmids for therapy and vaccination 1st Edition by Martin Schleef ISBN 3527302697 978-3527302697

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Product details: 

ISBN 10:3527302697 

ISBN 13:978-3527302697

Author:Martin Schleef 

This collection of 14 essays provides coverage of diverse issues in gene therapy and vaccination using nucleic acids. Among the topics are two background articles summarizing plasmids and their structures, several articles on clinical applications, modified vector systems, the use of plasmids in fish vaccination, manufacturing of plasmids, quality control of pDNA, and the market potential for DNA therapeutics. The majority of the contributors (and the editor) are specialists in Germany, with some authors in Portugal, Canada, the UK, France, and Spain. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Table of contents: 

The Biology of Plasmids
Wolfgang Schumann

Structures of Plasmid DNA
Torsten Schmidt, Karl Friehs, Erwin Flaschel

Genetic Vaccination with Plasmid Vectors
Jörg Reimann, Marcin Kwissa, Reinhold Schirmbeck

A Liposomal iNOS-Gene Therapy Approach to Prevent Neointimal Lesion Formation in Porcine Femoral Arteries
Manfred Rüdiger, Andreas Muhs, Jens Schletter, Angela Heischmann, Andreas Herrmann, Julia Dörge, Jürgen Schrader, Heiko E. Von Der Leyen

Immunotherapy of Chronic Hepatitis B by pCMV-S2.S DNA Vaccine
Marie-Louise Michel

pSG.MEPfTRAP – A First Generation Malaria DNA Vaccine Vector
Jörg Schneider, Sarah C. Gilbert, Adrian Hill

Polyvalent Vectors for Coexpression of Multiple Genes
Peter P. Müller, André Oumard, Dagmar Wirth, Andrea Kröger, Hansjörg Hauser

Form Follows Function: The Design of Minimalistic Immunogenically Defined Gene Expression (MIDGE®) Constructs
Claas Junghans, Matthias Schroff, Sven A. Koenig-Merediz, Jens Alfken, Colin Smith, Florian Sack, Reinhold Schirmbeck, Burghardt Wittig

Synthetic Genes for Prevention and Therapy: Implications on Safety and Efficacy of DNA Vaccines and Lentiviral Vectors
Kurt Bieler, Ralf Wagner

Plasmids in Fish Vaccination
Simon R. M. Jones

Plasmid Manufacturing – An Overview
Guilherme N. M. Ferreira, Duarte M. F. Prazeres, Joaquim M. S. Cabral, Martin Schleef

Quality Control of pDNA
Andreas Fels, Ruth Baier, Andreas Richter

From Research Data to Clinical Trials
James S. Robertson, Klaus Cichutek

Market Potential for DNA Therapeutics
Jürgen M. Dobmeyer, Rita Dobmeyer

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Tags: Martin Schleef, Plasmids, therapy