Phagocytes and Cellular Immunity 1st Edition by Hans H Gadebusch ISBN 0429276575 9781000477887

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ISBN 10: 0429276575 
ISBN 13: 9781000477887
Author: Hans H Gadebusch

The immune system is an intricate network of cells, tissues, and organs that work in harmony to protect the body from infections, foreign invaders, and harmful cells. Central to this defense mechanism are phagocytes—specialized immune cells that play an indispensable role in recognizing, engulfing, and eliminating pathogens. These cells are the first line of defense against a wide range of infectious agents, such as bacteria, viruses, and fungi, and are essential to the body’s ability to mount an effective immune response.

Phagocytosis, the process by which phagocytes engulf and digest pathogens, is an essential mechanism in both innate immunity (the body’s immediate, nonspecific defense) and adaptive immunity (the more specialized, long-term immune response). Phagocytes are not only key players in the initial immune response but also help to bridge the gap between innate and adaptive immunity by presenting antigens to other immune cells, such as T cells, which then activate the adaptive immune system to fight off infections more effectively.

Phagocytes and Cellular Immunity 1st Table of contents:

Part I: Introduction to the Immune System

1. Overview of the Immune System

   • Innate vs. Adaptive Immunity
   • Cells and Organs of the Immune System
   • Primary and Secondary Immune Responses
   • The Role of Phagocytes in Immune Surveillance

2. The Basics of Cellular Immunity

   • The Role of T Cells in Cellular Immunity
   • Cell-Mediated vs. Humoral Immunity
   • How Cellular Immunity Contributes to Defense Against Infections

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Part II: Phagocytes in the Immune System

3. Introduction to Phagocytes

   • What Are Phagocytes?
   • Types of Phagocytes: Neutrophils, Macrophages, Dendritic Cells
   • Phagocyte Origin and Development
   • Phagocyte Lifespan and Function in Immune Response

4. The Process of Phagocytosis

   • Recognition of Pathogens by Phagocytes
   • Engulfment: Mechanisms of Phagocytosis
   • The Phagosome and Phagolysosome Formation
   • Killing and Digestion of Pathogens

5. Molecular Mechanisms of Phagocyte Activation

   • Receptors Involved in Phagocytosis (PRRs, Fc Receptors, etc.)
   • Signaling Pathways and Intracellular Responses
   • ROS, NO, and the Role of Reactive Oxygen and Nitrogen Species in Pathogen Killing
   • Phagocytosis in Inflammation and Immune Modulation

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Part III: Phagocytes in Cellular Immunity

6. Macrophages and Dendritic Cells in Immune Responses

   • The Role of Macrophages in Inflammation and Immunity
   • Dendritic Cells and Antigen Presentation
   • Phagocytes as Sentinel Cells and Immune Regulators

7. The Interaction Between Phagocytes and T Cells

   • Antigen Presentation to T Cells
   • Co-stimulatory Signals and T Cell Activation
   • Cytokines and the Communication Between Phagocytes and T Cells
   • The Formation of the Immunological Synapse

8. Phagocytes and Cytotoxic T Cells

   • How Phagocytes Activate Cytotoxic T Cells
   • Phagocytes in the Elimination of Infected Cells
   • The Role of Perforin, Granzyme, and Fas/FasL in Cellular Immunity

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Part IV: Pathogen Evasion and Phagocyte Dysfunction

9. Pathogen Evasion Mechanisms Against Phagocytosis

   • Escape and Inhibition Strategies Used by Pathogens
   • Intracellular Survival Mechanisms of Bacteria, Viruses, and Fungi
   • The Role of Biofilms in Immune Evasion

10. Phagocyte Dysfunction and Immunodeficiency

    • Primary and Secondary Immunodeficiencies Affecting Phagocytes
    • Chronic Granulomatous Disease (CGD) and Other Disorders
    • The Impact of Phagocyte Dysfunction on Host Defense and Inflammation
    • Therapeutic Approaches to Enhance Phagocyte Function

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Part V: Clinical Relevance and Research

11. Phagocytes in Infectious Diseases

    • Phagocyte Role in Bacterial, Viral, and Fungal Infections
    • The Impact of Phagocytosis in Specific Pathogens (e.g., Mycobacteria, Listeria)
    • Phagocytes in Chronic Infections and Latency

12. Phagocytes in Autoimmune Diseases and Inflammation

    • The Role of Phagocytes in Autoimmune Disorders
    • Phagocyte Activation in Rheumatoid Arthritis, Lupus, and Inflammatory Bowel Disease
    • Phagocytes and Tissue Damage in Chronic Inflammation

13. Phagocytes and Cancer Immunity

    • Phagocyte-Mediated Tumor Surveillance
    • The Role of Tumor-Associated Macrophages (TAMs) in Cancer Progression
    • Phagocytosis as a Therapeutic Target in Cancer Immunotherapy

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Part VI: Future Directions in Phagocyte and Cellular Immunity Research

14. Recent Advances in Phagocyte Research

    • New Insights into Phagocyte Signaling Pathways
    • Phagocyte Heterogeneity and Plasticity
    • New Technologies for Studying Phagocyte Function

15. Emerging Therapeutic Strategies Targeting Phagocytes

    • Immunomodulation and Phagocyte-Targeted Therapies
    • Gene Therapy Approaches for Phagocyte Deficiencies
    • Phagocytes in Vaccination Strategies

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Hans H Gadebusch,Phagocytes,Cellular Immunity