Peptide Based Drug Design 1st Edition by Laszlo Otvos ISBN 1588299902 9781588299901
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ISBN 10: 1588299902
ISBN 13: 9781588299901
Author: Laszlo Otvos
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.
Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.
Peptide Based Drug Design 1st Table of contents:
Peptide-Based Drug Design: Here and Now
Laszlo Otvos Jr.
Pages 1-8
Strategies for the Discovery, Isolation, and Characterization of Natural Bioactive Peptides from the Immune System of Invertebrates
Philippe Bulet
Pages 9-29
Sequence Analysis of Antimicrobial Peptides by Tandem Mass Spectrometry
Christin Stegemann, Ralf Hoffmann
Pages 31-46
The Spot Technique: Synthesis and Screening of Peptide Macroarrays on Cellulose Membranes
Dirk F.H. Winkler, William D. Campbell
Pages 47-70
Analysis of Aβ Interactions Using ProteinChip Technology
Eleni Giannakis, Lin-Wai Hung, Keyla Perez Camacaro, David P. Smith, Kevin J. Barnham, John D. Wade
Pages 71-86
NMR in Peptide Drug Development
Jan-Christoph Westermann, David J. Craik
Pages 87-113
Molecular Dynamics Simulations of Peptides
Jeffrey Copps, Richard F. Murphy, Sandor Lovas
Pages 115-126
Short Linear Cationic Antimicrobial Peptides: Screening, Optimizing, and Prediction
Kai Hilpert, Christopher D. Fjell, Artem Cherkasov
Pages 127-159
Investigating the Mode of Action of Proline-Rich Antimicrobial Peptides Using a Genetic Approach: A Tool to Identify New Bacterial Targets Amenable to the Design of Novel Antibiotics
Marco Scocchi, Maura Mattiuzzo, Monica Benincasa, Nikolinka Antcheva, Alessandro Tossi, Renato Gennaro
Pages 161-176
Serum Stability of Peptides
Håvard Jenssen, Stein Ivar Aspmo
Pages 177-186
Preparation of Glycosylated Amino Acids Suitable for Fmoc Solid-Phase Assembly
Mare Cudic, Gayle D. Burstein
Pages 187-208
Synthesis of O-Phosphopeptides on Solid Phase
David Singer, Ralf Hoffmann
Pages 209-222
Peptidomimetics: Fmoc Solid-Phase Pseudopeptide Synthesis
Predrag Cudic, Maciej Stawikowski
Pages 223-246
Synthesis of Toll-Like Receptor-2 Targeting Lipopeptides as Self-Adjuvanting Vaccines
Brendon Y. Chua, Weiguang Zeng, David C. Jackson
Pages 247-261
Synthesis of a Multivalent, Multiepitope Vaccine Construct
Laszlo Otvos Jr
Pages 263-273
Cysteine-Containing Fusion Tag for Site-Specific Conjugation of Therapeutic and Imaging Agents to Targeting Proteins
Marina V. Backer, Zoia Levashova, Richard Levenson, Francis G. Blankenberg, Joseph M. Backer
Pages 275-294
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Tags: Laszlo Otvos, Peptide, Drug Design