Parkinson Disease Molecular Mechanisms Underlying Pathology 1st Edition by Patrik Verstreken ISBN 9780128038055 0128038055
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ISBN 10: 0128038055
ISBN 13: 9780128038055
Author: Patrik Verstreken
Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson’s pathology.
This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms.
Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.
- Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology
- Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies
- Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease
- Includes approximately 25 color Illustrations and diagrams to explain concepts and models
- Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease
Parkinson’s Disease Molecular Mechanisms Underlying Pathology 1st Edition Table of contents:
Chapter 1: The Neurogenetics of Parkinson’s Disease and Putative Links to Other Neurodegenerative Disorders
Abstract
1. Introduction
2. Definition of (Genetic) Parkinson’s Disease
3. Classification and Nomenclature of Monogenic Parkinson’s Disease
4. Monogenic Forms of Parkinson’s Disease and Parkinsonism
5. PARK-SNCA
6. PARK-LRRK2
7. PARK-VPS35
8. PARK-Parkin
9. PARK-PINK1
10. PARK-DJ-1
11. Recent Novel Parkinson’s Disease Candidate Genes
12. Systematic and Regularly Updated Overview of Parkinson’s Disease Mutations
13. Reduced Penetrance and Variable Expressivity of Genetic Parkinson’s Disease
14. Genetic Association Studies
15. Candidate Gene Studies in Parkinson’s Disease
16. Genome-Wide Association Studies
17. Gene–Environment Interactions in Parkinson’s Disease
18. Lessons Learned From Other Monogenic Neurodegenerative Diseases
19. Translational Genetics: From Animal Models to Personalized Treatments
20. Most Important Questions for Future Perspectives of PD Neurogenetics
Chapter 2: Electron Transport Chain
Abstract
1. Introduction
2. Glycolysis in the Cytosol
3. Impact of Electron Transport Chain Dysfunction on Neuronal Function
4. What Have the Genetics Taught Us About Electron Transport Chain Dysfunction and the Sporadic Forms of Parkinson’s Disease?
5. Correlation Between Findings Obtained Using Different Animal Models
6. Therapeutic Pathways Targeting the Electron Transport Chain
7. Conclusions
List of Abbreviations
Chapter 3: Mitochondrial Fission and Fusion
Abstract
1. Introduction
2. Fission and Fusion Machinery
3. Functions of Fission and Fusion in Neurons
4. Fission and Fusion is Linked to Neurodegeneration
5. PD Genes and Mitochondrial Morphology
6. Mitochondrial Dynamics and Mitochondrial Turnover
7. Therapeutic Potential of Targeting Fission and Fusion
8. Conclusions
Chapter 4: Axonal Mitochondrial Transport
Abstract
1. Prelude
2. On the Distribution of Power: Mitochondria to Match Supply and Demand
3. Mitochondrial Movement is Essential for Maintaining a Healthy Mitochondrial Population in Neurons
4. A Motor/Adaptor Complex Enables and Regulates Mitochondrial Trafficking
5. Linking PD and Mitochondrial Transport: Mitochondrial Dysfunction Causes Mitochondrial Arrest
6. Do Other Forms of PD Involve Defects in Mitochondrial Movement?
7. Summary: The Virtuous and Vicious Cycles that Link Mitochondrial Transport and Mitochondrial Health
Chapter 5: Mitophagy
Abstract
1. Introduction
2. Mitochondrial Quality Control
3. PINK1 and Parkin
4. PINK1-Parkin-Mediated Mitophagy
5. PINK1 and/or Parkin-Independent Selective Mitophagy
6. Methods to Detect Mitophagy
7. Outstanding Questions
Chapter 6: Autophagy
Abstract
1. Introduction
2. Lessons from the Genetics of Parkinsons Disease
3. Ageing and Autophagy
4. Autophagy in the Nervous System: Friend or Foe?
5. Autophagy Induction to Promote Neuronal Survival
6. Conclusions
Chapter 7: Endocytosis and Synaptic Function
Abstract
1. Introduction
2. The Synaptic Vesicle Cycle and PD
3. Exosome Release
4. Summary
Chapter 8: Neuroinflammation as a Potential Mechanism Underlying Parkinsons Disease
Abstract
1. Introduction
2. The Role of Glial Cells in PD
3. Involvement of Proinflammatory Substances and Oxidative Stress in PD
4. Infiltration of Lymphocytes in PD
5. Involvement of PD-related Genes in Neuroinflammation
6. Potential Antiinflammatory Treatments for PD
7. Summary and Conclusions
Acknowledgments
Chapter 9: Protein Translation in Parkinson’s Disease
Abstract
1. Protein Translation and its Regulation in Neurons
2. PD-Linked Mutations and Their Impact on Protein Translation
3. Protein Translation and Neurotoxicity in Parkinson’s Disease
4. Future Directions
Acknowledgments
Index
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Patrik Verstreken,Parkinson Disease,Molecular Mechanisms,Pathology