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Nuclear Signaling Pathways and Targeting Transcription in Cancer 1st Edition by Rakesh Kumar ISBN 1461480396 9781461480396

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Nuclear Signaling Pathways and Targeting Transcription in Cancer 1st Edition Weiwen Long Ph.D. Digital Instant Download

Author(s): Weiwen Long Ph.D., Bert W. O’Malley M.D. (auth.), Rakesh Kumar (eds.)
ISBN(s): 9781461480396, 1461480396
Edition: 1
File Details: PDF, 8.29 MB
Year: 2014
Language: english
SKU: EB-4333182 Category: Tags: , ,

Nuclear Signaling Pathways and Targeting Transcription in Cancer 1st Edition by Rakesh Kumar – Ebook PDF Instant Download/Delivery: 1461480396, 9781461480396
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ISBN 10: 1461480396 
ISBN 13: 9781461480396
Author: Rakesh Kumar

At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the “classic” papers as well as perspectives on future directions for the field.

Nuclear Signaling Pathways and Targeting Transcription in Cancer 1st Table of contents:

Chapter 1: Introduction to Nuclear Signaling in Cancer

  • Overview of Signal Transduction

  • Role of the Nucleus in Cellular Signaling

  • Cancer and Dysregulated Nuclear Pathways

Chapter 2: Key Nuclear Receptors and Their Signaling Mechanisms

  • Steroid Hormone Receptors

  • Orphan Nuclear Receptors

  • Crosstalk with Other Signaling Pathways

Chapter 3: Transcription Factors in Cancer

  • Oncogenic Transcription Factors

  • Tumor Suppressor Transcription Factors

  • Post-translational Modifications and Regulation

Chapter 4: Epigenetic Regulation of Nuclear Signaling

  • Chromatin Remodeling Complexes

  • DNA Methylation and Histone Modifications

  • Non-coding RNAs in Transcriptional Control

Chapter 5: Signal Transduction Pathways Targeting Transcription

  • MAPK/ERK Pathway

  • PI3K/AKT/mTOR Pathway

  • Wnt/β-catenin Pathway

  • Notch Signaling

Chapter 6: Nuclear Import and Export in Cancer Cells

  • Nuclear Transport Mechanisms

  • Dysregulation in Cancer

  • Therapeutic Targeting of Nuclear Transport

Chapter 7: Targeting Transcriptional Machinery in Cancer Therapy

  • Small Molecule Inhibitors

  • Epigenetic Drugs

  • Emerging Therapeutic Strategies

Chapter 8: Resistance Mechanisms to Transcription-targeted Therapies

  • Genetic and Epigenetic Changes

  • Compensatory Pathways

  • Overcoming Drug Resistance

Chapter 9: Biomarkers and Diagnostic Tools

  • Transcriptional Signatures

  • Nuclear Protein Localization

  • Liquid Biopsies and Molecular Imaging

Chapter 10: Future Perspectives and Challenges

  • Integrative Approaches in Nuclear Signaling Research

  • Personalized Medicine and Targeted Therapy

  • Technological Advances in Targeting Transcription

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Tags: Rakesh Kumar, Nuclear Signaling, Targeting