Nuclear Receptors in Drug Metabolism 1st Edition by Wen Xie ISBN 0470086793 9780470086797

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ISBN 10: 0470086793
ISBN 13: 9780470086797
Author: Wen Xie

Nuclear Receptors in Drug Metabolism 1st Table of contents:

Chapter 1. Drug Metabolism: Significance and Challenges (by Chandra Prakash & Alfin D.N. Vaz)
1.1 Introduction
1.2 Phase I Drug‑Metabolising Enzymes
1.3 Phase II Conjugative Enzymes
1.4 Drug Efflux Transporters
1.5 Drug Uptake Transporters
1.6 Challenges in Drug Metabolism
1.7 Summary
1.8 References

Chapter 2. Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic Receptors (by Tao Li, Junichiro Sonoda & Ronald M. Evans)
2.1 Introduction
2.2 Nuclear Receptor and Orphan Nuclear Receptor Superfamily
2.3 Orphan Nuclear Receptors as Xenobiotic Receptors and Their Implications in Phase I Enzyme Regulation
2.4 Perspectives
2.5 References

Chapter 3. Nuclear Receptor‑Mediated Regulation of Phase II Conjugating Enzymes (by Olivier Barbier)
3.1 Introduction
3.2 Phase II Drug Metabolising Enzymes
3.3 The Xenosensors CAR and PXR: 2 Master Regulators of Phase II Metabolism
3.4 AhR and Nrf2, Two Important Regulators of Phase II Enzymes
3.5 PPARs and Phase II XMEs Regulation
3.6 FXR/LXR and Phase II XMEs Regulation
3.7 HNF and Phase II XMEs Regulation
3.8 Regulation of Phase II Conjugating Enzymes by Steroid and Thyroid Receptors
3.9 Concluding Remarks and Perspectives
3.10 References

Chapter 4. Nuclear Receptor‑Mediated Regulation of Drug Transporters (by Oliver Burk)
4.1 Introduction
4.2 Drug Transporters
4.3 Induction of Drug Transporters by Activation of PXR and CAR
4.4 Induction of Drug Transporters by Activation of PPARα
4.5 Molecular Mechanism of PXR‑ and CAR‑Dependent Drug Transporter Regulation
4.6 Induction of Drug Transporter Expression and Drug Disposition
4.7 Conclusions and Future Perspectives
4.8 References

Chapter 5. Structure and Function of PXR and CAR (by X. Edward Zhou & H. Eric Xu)
5.1 Introduction
5.2 Structure and Function of PXR
5.3 Structure and Function of CAR
5.4 Concluding Remarks
5.5 References

Chapter 6. Xenobiotic Receptor Co‑Factors and Coregulators (by John Y. L. Chiang)
6.1 Regulation of PXR and CAR Nuclear Translocation
6.2 Nuclear Receptor Coregulators and Epigenetic Regulation of Gene Transcription
6.3 PXR and CAR Crosstalk with other Nuclear Receptors and Transcription Factors
6.4 PXR and CAR Regulation of Lipid and Glucose Homeostasis
6.5 Conclusion
6.6 References

Chapter 7. Animal Models of Xenobiotic Nuclear Receptors and Their Utility in Drug Development (by Haibiao Gong & Wen Xie)
7.1 Introduction
7.2 PXR and CAR Loss‑of‑Function (Knockout) Mouse Models
7.3 PXR and CAR Gain‑of‑Function (Transgenic) Mouse Models
7.4 Humanized Mouse Models
7.5 Utility of Xenobiotic Mouse Models in Pharmaceutical Development
7.6 Closing Remarks
7.7 References

Chapter 8. Nuclear Receptors and Drug‑Drug Interactions with Prescription Drugs and Herbal Medicines (by Rommel G. Tirona & Richard B. Kim)
8.1 Introduction
8.2 Prescription Drugs / Drug Classes Commonly Involved in Inductive Interactions
8.3 Herbal Drug Medicines Commonly Involved in Inductive Interactions
8.4 Pharmacology of Induction
8.5 Clinical Aspects of Induction‑Type Drug Interactions
8.6 Inhibition of Nuclear Receptors in Clinical Drug Interactions
8.7 Nuclear Receptor‑Mediated Drug Side‑Effects
8.8 Perspectives
8.9 References

Chapter 9. Genetic Variants of Xenobiotic Receptors and Their Implications in Drug Metabolism and Pharmacogenetics (by Jatinder Lamba & Erin G. Schuetz)
9.1 PXR (Pregnane X Receptor) Background
9.2 PXR Gene Structure
9.3 PXR Alternative mRNAs
9.4 Genetic Variants in PXR’s Exons and their Functional Consequences
9.5 Genetic Variants in Introns 2‑8 and the 3’‑UTR of PXR and their Functional Consequences
9.6 Resequencing Strategy for the PXR Promoter and Intron 1
9.7 Genetic Variation in the PXR Promoter and 5’‑UTR and its Functional Relevance
9.8 Genetic Variation in PXR’s Intron 1 and its Functional Relevance
9.9 SNPs in PXR’s Promoter and Intron 1 Affect Putative HNF Binding Sites
9.10 PXR SNPs Have Been Associated with Intestinal and Hepatic Inflammation and Diseases
9.11 PXR Structural Variation and other Genomic Features
9.12 PXR Summary
9.13 CAR‑Background
9.14 CAR Gene Structure
9.15 CAR Alternatively Spliced RNAs
9.16 CAR Genetic Variants (SNPs) and their Functional Consequences
9.17 CAR Summary
9.18 References

Chapter 10. Beyond PXR and CAR — Regulation of Xenobiotic Metabolism by Other Nuclear Receptors (by Martin Wagner, Gernot Zollner & Michael Trauner)
10.1 Introduction
10.2 Farnesoid X Receptor (FXR)
10.3 Hepatocyte Nuclear Factor 4 (HNF4)
10.4 Vitamin D Receptor (VDR)
10.5 Glucocorticoid Receptor
10.6 Peroxisome Proliferator‑Activated Receptors (PPARs)
10.7 Aryl Hydrocarbon Receptor (AhR)
10.8 Conclusions
10.9 References

Chapter 11. Emerging Role of Retinoid‑Related Orphan Receptor (ROR) and Its Crosstalk with LXR in the Regulation of Drug‑Metabolizing Enzymes (by Taira Wada & Wen Xie)
11.1 Introduction
11.2 Orphan Nuclear Receptor RORα
11.3 A Potential Role of RORs in Xeno‑ and Endobiotic Gene Regulation
11.4 LXR and Its Regulation of Drug Metabolizing Enzymes
11.5 A Functional Cross‑Talk Between RORα and LXR in the Regulation of Xeno‑ and Endobiotic Genes
11.6 Closing Remarks

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Tags: Wen Xie, Nuclear Receptors, Drug Metabolism