Nociceptin opioid 1st Edition by Gerald Litwack ISBN 2014100012 9782014100013

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ISBN 10: 2014100012 
ISBN 13: 9782014100013
Author: Gerald Litwack

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones.  A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on nociceptin opioid.

Nociceptin opioid 1st Table of contents:

Chapter One: Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception
Abstract
1 Nociception in Brief
2 Prospecting the Importance of the N-Terminal Tetrapeptide of Nociceptin(1–17)
3 Other Modifications to Nociceptin(1–17)
4 The Importance of Structure in Nociceptin Analogues
5 Recent Advances in ORL-1 Active Nociceptin Peptides
6 The Development of New Helix-Constrained Nociceptin Analogues
7 Biological Properties of Helical Nociceptin Mimetics
8 Concluding Remarks
Chapter Two: Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors
Abstract
1 Introduction
2 The Vertebrate Opioid Receptor Sequence Database
3 The Human Genome and the Evolution of Opioid Receptors
4 The Molecular Evolution of Vertebrate Opioid Family Receptors
5 Future Directions
6 Conclusions
Acknowledgments
Chapter Three: Ancestral Vertebrate Complexity of the Opioid System
Abstract
1 Introduction
2 Opioid Peptide Family
3 Opioid Receptor Family
4 Discussion: Complexity, Coevolution, and Divergence
5 Conclusions
Acknowledgement
Chapter Four: Synthesis and Biological Activity of Small Peptides as NOP and Opioid Receptors’ Ligands: View on Current Developments
Abstract
1 Introduction
2 Endogenous Opioid Peptides and Receptors: Nociceptin and NOP Receptor Ligands
3 Hexapeptides with NOP Receptor Affinity
4 Solid-Phase Peptide Synthesis
5 Conclusions
Acknowledgment
Chapter Five: Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein
Abstract
1 Introduction
2 Biological Activity by NST Through G Protein-Coupled Receptor
3 Pain Regulation Through an NST-Interacting Protein
4 Conclusions
Acknowledgment
Chapter Six: Nociceptin and Meiosis during Spermatogenesis in Postnatal Testes
Abstract
1 Introduction
2 Regulation of Nociceptin Expression by FSH Signaling in Sertoli Cells
3 Function of Nociceptin During Meiosis in Spermatocytes
4 Nociceptin is a Novel Paracrine Factor that is Induced in Sertoli Cells and Mediates to Germ Cells the Effect of FSH on Spermatogenesis
5 Nociceptin is a Novel Extrinsic Factor Inducing Rec8 Phosphorylation and Chromosome Dynamics During Meiosis in Spermatocytes
6 Conclusions
Acknowledgments
Chapter Seven: Orphanin FQ-ORL-1 Regulation of Reproduction and Reproductive Behavior in the Female
Abstract
1 Introduction
2 Ovarian Hormone Regulation of Reproductive Behavior and Neuroendocrine Feedback Loops
3 OFQ/N-ORL-1 Regulation of Sexual Receptivity
4 Ovarian Steroid Regulation of OFQ/N and ORL-1 Expression and Signaling
5 OFQ/N-ORL-1 Regulation of GnRH and LH Release During Positive and Negative Feedback
6 Conclusions
Acknowledgments
Chapter Eight: Effects of Nociceptin and Nocistatin on Uterine Contraction
Abstract
1 Roles of PNOC, N/OFQ, and NST in Different Peripheral Tissues
2 Presence of PNOC, N/OFQ, and NST in Uterine Tissue
3 The Effects and Mechanisms of Action of N/OFQ and NST on Uterine Contractility
4 Conclusions
Chapter Nine: Nociceptin/Orphanin FQ-NOP Receptor System in Inflammatory and Immune-Mediated Diseases
Abstract
1 A Brief Overview of the Immune Response
2 N/OFQ and Its Receptor
3 N/OFQ and NOP Receptor Expression in Leukocytes
4 Effects of NOP Receptor Activation on the Immune Response
5 NOP Receptor Activation and Inflammatory and Autoimmune Diseases
6 Molecular Mechanisms Underlying N/OFQ Actions on Immune Functions
7 Relationship Between N/OFQ, Stress, and HPA Axis
8 Conclusions
Acknowledgments
Chapter Ten: Endogenous Nociceptin System Involvement in Stress Responses and Anxiety Behavior
Abstract
1 Introduction
2 The Neuroanatomical Basis of Fear Conditioning
3 Evidence for a Role of Nociceptin in Fear Learning and Memory
4 Nociceptin and Neurochemical Substrates of Fear Conditioning: Focus on Biogenic Amines
5 Maternal Adaptations of the Nociceptin System
6 Conclusions
Chapter Eleven: The Neuronal Circuit Between Nociceptin/Orphanin FQ and Hypocretins/Orexins Coordinately Modulates Stress-Induced Analgesia and Anxiety-Related Behavior
Abstract
1 Introduction
2 The N/OFQ System
3 The Hypocretins/Orexins System
4 Interaction Between the N/OFQ and Hcrt Systems
5 Conclusions
Acknowledgments
Chapter Twelve: Nociceptin/Orphanin-FQ Modulation of Learning and Memory
Abstract
1 Introduction
2 N/OFQ Modulation of Mnemonic Functions
3 Mechanisms of N/OFQ-Mediated Modulation of Cognitive Functions
4 Conclusion and Remarks

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