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Neuroscience for Neurologists 1st Edition by Patrick F Chinnery ISBN 1860946577 9781860946578

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Neuroscience for Neurologists 1st Edition Patrick F. Chinnery Digital Instant Download

Author(s): Patrick F. Chinnery
ISBN(s): 9781860946578, 1860946577
Edition: 1
File Details: PDF, 30.11 MB
Year: 2006
Language: english
SKU: EB-1114948 Category: Tag:

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ISBN 10: 1860946577 
ISBN 13: 9781860946578
Author: Patrick F Chinnery

The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time to practice neurology, it also presents new challenges. How can established general neurologists keep up-to-date with clinically relevant scientific advances, and how can the specialist remain competent outside his own field? What should trainee neurologists learn to prepare themselves for the future career?Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area.Many of the chapters are co-written by a clinician and a basic scientist, and each has been subject to peer review — both by experts in the field and a “jobbing” general neurologist. This has ensured that the contributions reflect contemporary scientific thinking which is presented in a way that is easy to digest. The book includes generous use of diagrams to help explain difficult concepts, a glossary explaining the terminology, and provides information on links to web-based resources for further information.

Neuroscience for Neurologists 1st Table of contents:

1. Neurogenetics – Single Gene Disorders

  • Genetic Linkage Analysis

  • Linkage Disequilibrium and Association

  • Mutational Spectrum

  • Molecular Genetic Tools

  • Molecular Genetic Testing

  • Animal Models

  • Web-based Information for Genetic Diagnosis and Testing

  • Outlook

  • Acknowledgements

  • References

2. Neurogenetics II: Complex Disorders

  • Guiding Principles

  • Applications to Clinical Neurology

  • Tauopathies

  • New Technologies

  • Conclusions

  • Appendix A: Human Genetic Variation

  • Appendix B: Genetic Linkage and Association Analyses

  • References

3. Functional Genomics and Proteomics: Application in Neurosciences

  • Functional Genomics

  • RNA Preparation

  • Differential Display

  • SAGE

  • Microarrays

  • Real Time Q-PCR

  • Proteomics

  • Two Dimensional Gel Electrophoresis

  • ICAT – Isotope Coded Affinity Tags

  • Protein Microarrays

  • Mass Spectrometry

  • SELDI

  • Future Prospects

  • Acknowledgements

  • References

4. Mitochondria

  • Historical Introduction

  • What are Mitochondria and What Do They Do?

  • The Genetic Basis of Mitochondrial Biogenesis

  • Mitochondrial Disease: Genotype and Phenotype

  • Mitochondrial Genetic Factors

  • Confirming Suspected Mitochondrial Disease

  • Managing Mitochondrial Disease – The Future

  • Animal Models

  • Conclusion

  • Acknowledgements

  • References

5. Nanotechnology for Neuronal Ion Channels

  • Channels – Essential for Neuronal Excitability

  • History of the Voltage Clamp Technique

  • Application to Clinical Neurology

  • Principles Behind the Techniques

  • Potential Application of the Technologies in the Future

  • Conclusions

  • Acknowledgements

  • Appendix 1: Glossary of Terms

  • Appendix 2: Associated Websites of Interest

  • References

6. Molecular and Cellular Pathways of Neurodegeneration in Motor Neurone Disease

  • What Do We Know about the Causes of Motor Neurone Degeneration?

  • Genetics of ALS/MND

  • Oxidative Stress

  • Excitotoxicity

  • Mitochondrial Dysfunction

  • Cytoskeletal Elements and Axonal Transport

  • Protein Aggregation

  • Inflammatory Cascades and the Role of Non-Neuronal Cells

  • Apoptosis

  • Cell-Specific Features of Motor Neurones Which May Predispose to Neurodegeneration

  • Conclusions

  • Acknowledgements

  • References

7. Neurodegenerative Disorders: Parkinson’s Disease and Huntington’s Disease

  • Parkinson’s Disease

  • Huntington’s Disease

  • Conclusions

  • References

8. Molecular Pathogenesis of Neuroinflammation

  • A Brief History of Immune Privilege

  • Experimental Autoimmune Encephalomyelitis (EAE) – An Animal Model

  • Contributions of Modern Techniques to EAE and MS Research

  • Microdissection and Single-Cell Molecular Analysis

  • Novel Techniques and Their Future Role in Clinical Neurology

  • Conclusion

  • Acknowledgements

  • References

9. Neurovirology

  • Introduction

  • Specific Techniques and Their Applications

  • Acknowledgements

  • References

10. Molecular Neurology of Prion Disease

  • Introduction to Prions and Historical Perspective

  • Molecular Biology of Prions

  • Application to Clinical Neurology

  • References

11. Monitoring and Interpretation of Intracranial Pressure (ICP)

  • Methods of Measurement

  • Typical Events and Trends in ICP Monitoring

  • Waveform Analysis of ICP

  • Pressure-Volume Compensatory Reserve

  • Cerebrovascular Pressure Reactivity

  • Other Methods of ICP Analysis

  • Practical Use: “Optimal CPP” and Trend Analysis

  • ICP in Hydrocephalus and Benign Intracranial Hypertension

  • Non-Invasive ICP and CPP Monitoring

  • Is ICP Monitoring Useful?

  • Acknowledgements

  • References

12. Cerebral Perfusion and Stroke

  • Cerebrovascular Anatomy

  • Measurement Methods

  • Regulation of Cerebral Circulation

  • Responses to Focal Ischaemia

  • The Ischaemic Penumbra

  • Infarction Mechanisms

  • Summary

  • References

13. A Review of Structural Magnetic Resonance Neuroimaging

  • Definition(s) of Structural MRI

  • Applications

  • The Next Ten Years

  • Conclusion

  • Acknowledgements

  • References

14. Applications of Positron Emission Tomography (PET) in Neurology

  • Principles of PET

  • Clinical Applications

  • Future Applications

  • References

15. Functional Magnetic Resonance Imaging (fMRI)

  • Principles

  • Clinical Applications

  • fMRI as a Marker of Pathological State

  • Integration with Other MRI Techniques and Future Directions

  • Acknowledgements

  • References

16. How to Spot Bias and Other Potential Problems in Randomised Controlled Trials

  • Bias

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Tags: Patrick F Chinnery, Neuroscience, Neurologists