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Nerve and Muscle 4th Edition by Richard D Keynes, David J Aidley, Christopher LH Huang ISBN 0521519551 9780521519557

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Nerve and Muscle Keynes R.D. Digital Instant Download

Author(s): Keynes R.D., Aidley D.J., Huang C.L.-H.
ISBN(s): 9780521519557, 0521519551
Edition: draft, 4ed
File Details: PDF, 3.41 MB
Year: 2011
Language: english
SKU: EB-2044850 Category: Tags: , ,

Nerve and Muscle 4th Edition by Richard D Keynes, David J Aidley, Christopher LH Huang – Ebook PDF Instant Download/Delivery: 0521519551, 9780521519557
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ISBN 10: 0521519551 
ISBN 13: 9780521519557
Author: Richard D Keynes, David J Aidley, Christopher LH Huang

Written with undergraduate students in mind, the new edition of this classic textbook provides a compact introduction to the physiology of nerve and muscle. It gives a straightforward account of the fundamentals accompanied by some of the experimental evidence upon which this understanding is based. It first explores the nature of nerve impulses, clarifying their mechanisms in terms of ion flow through molecular channels in cell membranes. There then follows an account of the synaptic transmission processes by which one excitable cell influences activity in another. Finally, the emphasis turns to the consequences of excitable activity in the activation of contraction in skeletal, cardiac and smooth muscle, highlighting the relationships between cellular structure and function. This fourth edition includes new material on the molecular nature of ion channels, the activation of skeletal muscle and the function of cardiac and smooth muscle, reflecting exciting new developments in these rapidly growing fields.

Nerve and Muscle 4th Table of contents:

Chapter 1 Structural organization of the nervous system
1.1 Nervous systems
1.2 The anatomy of a neuron
1.3 Non-myelinated nerve fibres
1.4 Myelinated nerve fibres
Chapter 2 Resting and action potentials
2.1 Electrophysiological recording methods
2.2 Intracellular recording of the membrane potential
2.3 Extracellular recording of the nervous impulse
2.4 Excitation
Chapter 3 The ionic permeability of the nerve membrane
3.1 Structure of the cell membrane
3.2 Distribution of ions in nerve and muscle
3.3 The genesis of the resting potential
3.4 The Donnan equilibrium system in muscle
3.5 The active transport of ions
Chapter 4 Membrane permeability changes during excitation
4.1 The impedance change during the spike
4.2 The sodium hypothesis
4.3 Voltage-clamp experiments
4.4 Patch-clamp studies
Chapter 5 Voltage-gated ion channels
5.1 cDNA sequencing studies
5.2 The primary structure of voltage-gated ion channels
5.3 The sodium gating current
5.4 The screw-helical mechanism of voltage-gating
5.5 The ionic selectivity of voltage-gated channels
Chapter 6 Cable theory and saltatory conduction
6.1 The spread of potential changes in a cable system
6.2 Saltatory conduction in myelinated nerves
6.3 Factors affecting conduction velocity
6.4 Factors affecting the threshold for excitation
6.5 After-potentials
Chapter 7 Neuromuscular transmission
7.1 The neuromuscular junction
7.2 Chemical transmission
7.3 Post-synaptic responses
7.4 Pre-synaptic events
Chapter 8 Synaptic transmission in the nervous system
8.1 Synaptic excitation in motoneurons
8.2 Inhibition in motoneurons
8.3 Interaction of IPSPs with EPSPs
8.4 Pre-synaptic inhibition
8.5 Slow synaptic potentials
8.6 G-protein-linked receptors
8.7 Electrotonic synapses
Chapter 9 The mechanism of contraction in skeletal muscle
9.1 Anatomy
9.2 The structure of the myofibril
9.3 The sliding-filament theory
9.4 The molecular basis of contraction
Chapter 10 The activation of skeletal muscle
10.1 Ion channels in the membrane of skeletal muscle
10.2 Action potential generation in surface and tubular membranes of skeletal muscle
10.3 Excitation–contraction coupling in skeletal muscle
10.4 Involvement of Ca2+ ions in excitation–contraction coupling
10.5 Internal membrane systems
10.6 Triggering molecules for the release of sarcoplasmic reticular calcium
10.7 Tubular voltage detection mechanisms triggering excitation–contraction coupling
10.8 Calcium release from the sarcoplasmic reticulum through the ryanodine receptor
10.9 Triggering of ryanodine receptor opening through configurational coupling to the dihydropyridine receptor
10.10 Restoration of sarcoplasmic reticular calcium following repolarization
10.11 Overview of excitation–contraction coupling in skeletal muscle
Chapter 11 Contractile function in skeletal muscle
11.1 Isometric and isotonic contractions
11.2 Isometric twitch and tetanus
11.3 Isotonic contractions
11.4 Energetics of contraction
11.5 Work and power
11.6 Heat production
11.7 Efficiency
11.8 The energy source
11.9 Muscular fatigue
11.10 Energy balances during muscular exercise
11.11 Ionic and osmotic balances during muscular exercise
11.12 The effects of training
Chapter 12 Cardiac muscle
12.1 Structure and organization of cardiac cells
12.2 The electrical initiation of the heartbeat
12.3 The cardiac action potential
12.4 Ionic currents in cardiac muscle
12.5 The electrocardiogram
12.6 Cardiac excitation–contraction coupling
12.7 Nervous control of the heart
12.8 Cardiac arrhythmogenesis
Chapter 13 Smooth muscle
13.1 Structure
13.2 Excitation
13.3 Excitation–contraction coupling
13.4 Contractile mechanism
13.5 Mechanical properties

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Richard D Keynes,David J Aidley,Christopher LH Huang,Nerve,Muscle