Multidetector Computed Tomography in Cerebrovascular Disease CT Perfusion Imaging 1st Edition by Kenneth Miles, James D Eastwood, Matthias Konig ISBN 1842143158 9781842143155

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ISBN 10: 1842143158 
ISBN 13: 9781842143155
Author: Kenneth Miles, James D Eastwood, Matthias Konig

Multidetector Computed Tomography in Cerebrovascular Disease CT Perfusion Imaging 1st Table of contents:

1. Cerebral Perfusion Computed Tomography: A Historical Perspective

• Anatomical and Physiological Knowledge in Ancient Civilisations

• The Development of Modern Anatomy

• Anatomy and Imaging

• Physiology and the Cerebral Circulation

• Perfusion CT: Combining Anatomical Imaging and Quantitative Physiology

• References

2. Scientific Basis and Validation

• Introduction

• Theory

  • Fick Principle

  • No Outflow Assumption

  • Impulse Residue Function

  • Convolution and Deconvolution

  • Derivation of Hemodynamic Parameters from Blood Flow-Scaled IRF

• Assumptions and Issues of Concern

  • Calibration of the CT Scanner

  • Delay and Dispersion of Arterial TDC

  • Partial Volume Averaging

  • Recirculation

• Practical Issues

  • Contrast, Noise and Radiation Dose

  • Image Interval and Scanning Duration

• Validation (Accuracy) and Reproducibility

  • Animal Studies

  • Patient Studies

• Quantifying the Permeability of the Blood-Brain Barrier

• References

3. Implementing Deconvolution Analysis for Perfusion CT

• Introduction

• Deconvolution Method

• Constrained Deconvolution Method

• Effects of Delay in Arterial Input Curve

  • Tissue Curve Lags Artery Curve

  • Tissue Curve Leads Artery Curve

• Effects of Dispersion of Arterial Input Curve

• Conclusion

• References

4. Image Acquisition and Contrast Enhancement Protocols for Perfusion CT

• Introduction and Overview

• Image Acquisition

  • Overall Length of Time of the Image Series

  • The Number and Frequency of Images

  • The Number and Thickness of CT Slices

  • X-ray Exposure Factors

• Contrast Enhancement

  • Type of Contrast Medium

  • Volume and Concentration of Contrast Medium

• Summary

• References

5. Image Processing

• Introduction

• Tissue and Vascular Segmentation From CT Perfusion Maps

  • Segmentation of Cerebral Tissues

  • Segmentation of Vascular Structures

  • Segmentation of Gray and White Matter

  • Segmentation of Viable and Non-Viable Tissue

  • CBF and CBV Thresholds

• Conclusion

• References

6. Cerebrovascular Physiology and Pathophysiology

• The Control of Cerebral Blood Flow

• Biochemical Mediators of Cerebrovascular Tone

• The Blood-Brain Barrier

• Biochemical Mediators of Blood-Brain Barrier Permeability

• Acute Cerebral Ischemia

• Vasospasm in Subarachnoid Hemorrhage

• Traumatic Brain Injury

• Tumor

• Summary

• References

7. Diagnosis of Acute Stroke

• References

8. Selection of Stroke Patients for Acute Treatment Using Perfusion CT and CT Angiography

• Current Concepts About Thrombolysis

• Imaging the Acute Stroke Patient

• Perfusion CT and CT Angiography for Acute Stroke Imaging

• PCT/CTA or MRI: Which One to Choose to Select Stroke Patients for Acute Treatment?

• How to Integrate PCT/CTA Results in the Management of Acute Stroke Patients

• Conclusion

• References

9. Vasospasm After Subarachnoid Hemorrhage: Utility of Perfusion CT and CT Angiography on Diagnosis and Management

• The Burden of Vasospasm Following Intracranial Aneurysm Rupture

• Conventional Imaging of Vasospasm

• Perfusion CT and CT Angiography as an Alternative to TCD for Vasospasm Detection and Management Decision

• Conclusion

• References

10. Practical Approach to CT Perfusion Scan Analysis for the Physician

• Introduction

• CT Perfusion Scanning Strategies

• Evaluating the Data Set for Motion

• Importance of Vascular Input Regions of Interest

  • Choice of Artery

  • Choice of Vein

  • Manual Optimization of Vascular ROI Placement

• Analysis Techniques in Acute Stroke

  • Initial Analysis: Use of an Unobstructed Artery

  • Secondary Analysis: Use of the Affected Artery

  • Tissue ROIs: Gray Matter, White Matter and Mixed

  • Vascular Pixels

• Analysis Techniques in Chronic Ischemia

• Conclusion

• References

11. Combining Perfusion CT with CT Angiography

• Introduction

• CT Angiography in Acute Stroke

• CT Angiography and Perfusion Imaging are Complementary

• Acute Basilar Artery Stroke

• Whole-Brain Imaging of Perfused Cerebral Blood Volume

• Assessing Perfusion with CT Angiography Source Images

• Summary

• References

12. Comparison with Other Imaging Techniques

• Introduction

• Comparison with Xenon CT

• Comparison with Magnetic Resonance Imaging

• Comparison with Positron Emission Tomography

• Comparison with Single-Photon Emission CT

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Tags: Kenneth Miles, James D Eastwood, Matthias Konig, Computed Tomography, Cerebrovascular Disease