Molecular and Cellular Basis of Metastasis Road to Therapy 1st Edition by Danny R Welch, Paul B Fisher ISBN 0128041404 9780128041406

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ISBN 10: 0128041404 
ISBN 13: 9780128041406
Author: Danny R Welch, Paul B Fisher

Molecular and Cellular Basis of Metastasis Road to Therapy 1st Table of contents:

Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here
Abstract
1 Introduction
2 Preclinical In Vitro and In Vivo Models of Metastasis
3 Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level)
4 Approaches Used to Detect Metastatic Lesions (on a Clinical Level)
5 Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics)
6 Challenges Faced in Detecting Metastatic Cells
7 Conclusions and Future Directions
Acknowledgments
Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment
Abstract
1 Introduction
2 Models to Study Tumor Cell Dormancy
3 Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy
4 Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment
5 Endosteal and Perivascular Niches Support Cancer Cell Dormancy
6 Reactivation from Dormancy
7 The Immune System and Dormancy
8 Summary and Outlook
Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches
Abstract
1 Introduction
2 Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations
3 Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis
4 Conclusions
Acknowledgments
Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action
Abstract
Concluding Thoughts
Acknowledgments
Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy
Abstract
1 Introduction
2 Key Players
3 Invasion and Intravasation
4 Survival and Extravasation
5 Ectopic Growth
6 Therapeutic Implications
Acknowledgments
Chapter Six: MicroRNA and Metastasis
Abstract
1 MicroRNAs
2 miRNAs in Cancer
3 miRNA Regulation of Metastasis
4 miRNAs as Therapeutic Targets
Chapter Seven: Plasticity of Cancer Cell Invasion—Mechanisms and Implications for Therapy
Abstract
1 Introduction
2 Cancer Types and Their Migration Modes
3 Cancer Cell Migration as a Plastic and Adaptive Process
4 Therapeutic Targeting of Cancer Cell Migration—Implications for Anticancer Therapy
5 Conclusions
6 Future Implications
Acknowledgments
Chapter Eight: Cytokine Regulation of Metastasis and Tumorigenicity
Abstract
1 Introduction
2 Interleukins
3 Chemokines
4 Chemokines in Therapy
5 Interferons
6 Tumor Necrosis Factor
7 Closing Remarks

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Tags: Danny R Welch, Paul B Fisher, Cellular Basis, Metastasis Road