Molecular and cell biology of pain 1st Edition by Theodore Price Gregory Dussor ISBN 0128013893 9780128013892

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ISBN 10: 0128013893 
ISBN 13: 9780128013892
Author: Theodore Price Gregory Dussor

Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology.

• Written by future leaders in the pain field
• Covers a wide range of targets
• Contains provocative ideas about the future direction of the pain field.

Molecular and cell biology of pain 1st Table of contents:

Chapter One: An Introduction to Pain Pathways and Pain “Targets”
Abstract
1 An Introduction to Pain and Pain Pathways
2 Ion Channels, Receptors, and Other “Targets” for Persistent Inflammatory or Neuropathic Pain
3 Summary
Acknowledgments
Chapter Two: Peripheral Scaffolding and Signaling Pathways in Inflammatory Pain
Abstract
1 Introduction
2 Inflammatory Mediators
3 Signaling Mechanisms
4 Scaffolding Structures
5 Concluding Remarks
Chapter Three: Contribution of Mechanosensitive Ion Channels to Somatosensation
Abstract
1 The Evolution of Mechanosensing
2 MSCs in Nociceptors
3 Difficulties in Identifying Genes Encoding MSCs
4 Gating Mechanisms of MSCs
5 Role of MSCs in the Transmission of Noxious Mechanical Inputs
6 Sensitization of MSCs Is Necessary for the Induction of Mechanical Allodynia
7 Potassium-Selective MSCs in Nociceptors
Chapter Four: Sensory TRP Channels: The Key Transducers of Nociception and Pain
Abstract
1 Introduction
2 Ion Channels in the TRPV Subfamily
3 Ion Channels in the TRPM Subfamily
4 Ion Channels in the TRPA Subfamily
Acknowledgments
Chapter Five: The Contribution of Mitochondria to Sensory Processing and Pain
Abstract
1 Introduction
2 Role of Mitochondria in Normal Sensory Processing and Acute Pain
3 Clinical Evidence of Mitochondrial Dysfunction in Painful Conditions
4 Preclinical Evidence of Mitochondrial Dysfunction in Chronic Pain States
5 Future Perspectives
Acknowledgments
Chapter Six: Regulation of Gene Expression and Pain States by Epigenetic Mechanisms
Abstract
1 Introduction
2 Epigenetic Mechanisms and Gene Expression
3 Epigenetic Regulation of Synaptic Plasticity in Learning and Memory
4 Epigenetic Mechanisms and Pain States
5 Future Directions
Acknowledgments
Chapter Seven: Translational Control of Chronic Pain
Abstract
1 Introduction
2 Repair of Injured Tissue
3 Case for Axonal Translation
4 Regulation of Protein Synthesis
5 Transport and Storage of mRNAs
6 Conclusions and Perspectives
7 Translational Control of Central Sensitization
8 Conclusions
Chapter Eight: MicroRNA Biology and Pain
Abstract
1 Introduction
2 History and Biogenesis
3 Genomic Location of miRNAs
4 miRNA Nomenclature
5 miRNA Target Determination
6 miRNA Detection, Quantification, and Functional Studies
7 Circulating miRNAs
8 miRNAs and Pain
9 Challenges Associated with miRNA Research
10 Conclusions
Acknowledgments
Chapter Nine: Role of Extracellular Damage-Associated Molecular Pattern Molecules (DAMPs) as Mediators of Persistent Pain
Abstract
1 Introduction
2 High-Mobility Group Box 1
3 S100 Proteins
4 Heat-Shock Proteins
5 microRNA
6 Purine Metabolites
7 Summary and Perspective
Chapter Ten: mGluRs Head to Toe in Pain
Abstract
1 Introduction
2 Metabotropic Receptors
3 Analysis of mGluRs at Each Level of the Pain Neuraxis
4 Conclusion
Chapter Eleven: Nonneuronal Central Mechanisms of Pain: Glia and Immune Response
Abstract
1 Introduction
2 The Central Multipartite Synapse in the Mechanisms of Chronic Pain
3 Glial Activation or Reactivity: A Change in Cellular Phenotype in Pain States
4 Triggers of the Change of Glial Phenotype in Pain States
5 Drugs with Glial Modulation Capabilities and Efficacy in Preclinical Models of Pain
6 What It Is Known of Glial Cells in Humans with Pain Conditions?
7 Glial Cells: Human Versus Rodents and Other Species
8 Clinical Data Using Glial Modulating Agents
9 Conclusions
Acknowledgments
Chapter Twelve: Synaptic Inhibition and Disinhibition in the Spinal Dorsal Horn
Abstract
1 Introduction
2 Synthesis and Handling of Inhibitory Neurotransmitters
3 GABA and Glycine Receptors
4 Driving Force and Ion Flux
5 Regulation of Intracellular Anion Concentrations
6 Mechanisms of Inhibition
7 Inhibitory Interneurons and Dorsal Horn Circuitry
8 Pathological Changes in Inhibition
9 Implications for Therapeutic Interventions
10 Summary
Chapter Thirteen: Dendritic Spine Dysgenesis in Neuropathic Pain
Abstract
1 A Brief History
2 Dendritic Spine Morphology
3 Dendritic Spines in Synaptic Function
4 Dendritic Spines in Pathology
5 Dendritic Spines in Neuropathic Pain
6 Spinal Cord Injury
7 Peripheral Nerve Injury
8 Diabetes Mellitus
9 Thermal Burn Injury
10 Molecular Control of Dendritic Spine Dysgenesis
11 Spinal Memory Mechanism in Neuropathic Pain
12 Final Perspectives
Chapter Fourteen: Commonalities Between Pain and Memory Mechanisms and Their Meaning for Understanding Chronic Pain
Abstract
1 Introduction: Pain Plasticity and “Pain Memory”
2 The Adaptive Nature of Pain Plasticity
3 The Peripheral Nociceptor as the Locus of “Pain Memory,” Focus on Translation Control
4 “Pain Memory” in the Spinal Dorsal Horn
5 Clinical Implications of Pain Memory
6 Conclusions
Acknowledgments
Chapter Fifteen: Dietary Influence on Pain via the Immune System
Abstract
1 Cytokines and Immunity
2 Cytokines and Chronic Pain
3 Obesity and Pain
4 Diet and Inflammation
5 Omega-3 and Omega-6 PUFAs
6 Saturated Fats
7 Grape Seed Extract
8 Green Tea Extract
9 Soy Products
10 Broccoli
11 Carotenoids
12 Ginger
13 Ginseng
14 Caffeine
15 Grains and Gluten
16 Ketogenic Diets
17 Dietary Interventions
18 Conclusions
Chapter Sixteen: Chemotherapy-Induced Peripheral Neuropathy
Abstract
1 Chemotherapy-Induced Neuropathy: An Introduction
2 Classes of Chemotherapeutics
3 Clinical Assessment of CIPN
4 Experimental Studies: Animal Models of CIPN
5 Experimental Studies: In Vitro Models of CIPN
6 Proposed Mechanisms Underlying CIPN
7 Challenges to CIPN Research
Chapter Seventeen: Stress and Chronic Pelvic Pain
Abstract
1 Introduction
2 Central and Peripheral Regulation of the Stress Pathway
3 Consequences of Early Life Stress
4 Irritable Bowel Syndrome
5 Interstitial Cystitis/Painful Bladder Syndrome
6 Vulvodynia
7 Chronic Prostatitis/Chronic Pelvic Pain Syndrome
8 Conclusions
Chapter Eighteen: Meningeal Afferent Signaling and the Pathophysiology of Migraine
Abstract
1 Introduction
2 Features of Migraine
3 Current Migraine Treatments
4 Anatomy of the Meningeal Afferent System
5 Migraine Pathophysiology
6 Potential Mechanisms of Dural Afferent Activation
7 Ion Channels and Dural Afferent Activation
8 Dural Afferent Input May Lead to Neuroplasticity
9 Neuroplasticity and Migraine
10 CGRP and Migraine Plasticity
11 BDNF and Migraine
12 Conclusion
Acknowledgments
Chapter Nineteen: Chronic Pain Syndromes, Mechanisms, and Current Treatments
Abstract
1 Cancer Pain
2 Central Poststroke Pain
3 Chronic Pelvic Pain
4 Complex Regional Pain Syndrome
5 Failed Back Syndrome
6 Fibromyalgia
7 Irritable Bowel Syndrome
8 Migraine
9 Multiple Sclerosis
10 Peripheral Neuropathic Pain
11 Persistent Postsurgical Pain
12 Phantom Limb Pain
13 Postherpetic Neuralgia
14 Rheumatoid Arthritis
15 Trigeminal Neuralgia
16 Future Directions

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