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Metallo Drugs Development and Action of Anticancer Agents 1st Edition by Astrid Sigel, Helmut Sigel ISBN 3110469847 9783110469844

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Metallo Drugs Development and Action of Anticancer Agents 1st Edition Astrid Sigel Digital Instant Download

Author(s): Astrid Sigel, Helmut Sigel
ISBN(s): 9783110469844, 3110469847
Edition: 1
File Details: PDF, 10.20 MB
Year: 2018
Language: english
SKU: EB-10848388 Category: Tags: ,

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ISBN 10: 3110469847 
ISBN 13: 9783110469844
Author: Astrid Sigel, Helmut Sigel

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic … not forgetting that it also provides excellent information for teaching.

Metallo Drugs Development and Action of Anticancer Agents 1st Table of contents:

1. Introduction to the Wider Field of Metallo-Drugs
Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel

2. Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions
Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel

3. Polynuclear Platinum Drugs: Covalent and Non-covalent DNA-Binding Agents
Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel

4. Different Drugs, Different Actions: The Actions and Consequences of Trans and Cationic Platinum Drugs
Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel

5. Platinum(IV) Drugs
Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel

6. The Ruthenium Drugs KP1019 and NAMI-A: Our Current Understanding of Their Actions
Babak and Wee Han

7. Ruthenium Piano-Stool Organometallic Drugs
Venkatesh and Peter J. Sadler

8. The Gold Drugs
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

9. Titanium Drugs
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

10. Vanadium Drugs
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

11. Non-covalent Metallo-Drugs: Targeting Junction Structures
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

12. Metallo-Drugs that Target Proteins
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

13. Non-canonical Nucleic Acid Targets: Metallo-Drugs that Act on Quadruplexes
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

14. Targeting, Delivery and Nanoscience of Metallo-Drugs
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

15. Metallo-Intercalators
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott

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Tags: Astrid Sigel, Helmut Sigel, Metallo Drugs, Anticancer Agents