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Medicinal Natural Products A Biosynthetic Approach 2nd Edition by Paul M Dewick ISBN 0470846275 9780470846278

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Medicinal Natural Products A Biosynthetic Approach 2nd Edition Paul M. Dewick Digital Instant Download

Author(s): Paul M. Dewick
ISBN(s): 9780470846278, 0470846275
Edition: 2
File Details: PDF, 5.37 MB
Year: 2002
Language: english
SKU: EB-50027354 Category: Tag:

Medicinal Natural Products A Biosynthetic Approach 2nd Edition by Paul M Dewick – Ebook PDF Instant Download/Delivery: 0470846275, 9780470846278
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ISBN 10: 0470846275
ISBN 13: 9780470846278
Author: Paul M Dewick

Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations.
* Adopts a novel biosynthetic theme rather than a traditional descriptive approach
* Includes extensive further reading at the end of the chapter
* Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products
* Includes the latest developments in the field
* New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids
* User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations

Medicinal Natural Products A Biosynthetic Approach 2nd Table of contents:

1 About this book, and how to use it
The subject
The aim
The approach
The topics
The figures
Further reading
What to study
What to learn
Nomenclature
Conventions regarding acids, bases, and ions
Some common abbreviations
Further reading
2 Secondary metabolism: the building blocks and construction mechanisms
Primary and secondary metabolism
The building blocks
The construction mechanisms
Alkylation reactions: nucleophilic substitution
Alkylation reactions: electrophilic addition
Wagner–Meerwein rearrangements
Aldol and Claisen reactions
Imine formation and the Mannich reaction
Amino acids and transamination
Decarboxylation reactions
Oxidation and reduction reactions
Dehydrogenases
Oxidases
Monooxygenases
Dioxygenases
Amine oxidases
Baeyer–Villiger monooxygenases
Phenolic oxidative coupling
Halogenation reactions
Glycosylation reactions
Elucidating biosynthetic pathways
Further reading
3 The acetate pathway: fatty acids and polyketides
Fatty acid synthase: saturated fatty acids
Unsaturated fatty acids
Uncommon fatty acids
Prostaglandins
Thromboxanes
Leukotrienes
Polyketide synthases: generalities
Polyketide synthases: macrolides
Polyketide synthases: linear polyketides and polyethers
Diels–Alder cyclizations
Polyketide synthases: aromatics
Cyclizations
Post-polyketide synthase modifications
Starter groups
Further reading
4 The shikimate pathway: aromatic amino acids and phenylpropanoids
Aromatic amino acids and simple benzoic acids
Phenylpropanoids
Cinnamic acids and esters
Lignans and lignin
Phenylpropenes
Benzoic acids from C6C3 compounds
Coumarins
Aromatic polyketides
Styrylpyrones, diarylheptanoids
Flavonoids and stilbenes
Flavonolignans
Isoflavonoids
Terpenoid quinones
Further reading
5 The mevalonate and methylerythritol phosphate pathways: terpenoids and steroids
Mevalonic acid and methylerythritol phosphate
Hemiterpenes (C5)
Monoterpenes (C10)
Irregular monoterpenes
Iridoids (C10)
Sesquiterpenes (C15)
Diterpenes (C20)
Sesterterpenes (C25)
Triterpenes (C30)
Triterpenoid saponins
Steroids
Stereochemistry and nomenclature
Cholesterol
Phytosterols
Vitamin D
Steroidal saponins
Cardioactive glycosides
Bile acids
Adrenocortical hormones/corticosteroids
Semi-synthesis of corticosteroids
Progestogens
Oestrogens
Androgens
Tetraterpenes (C40)
Higher terpenoids
Further reading
6 Alkaloids
Alkaloids derived from ornithine
Polyamines
Pyrrolidine and tropane alkaloids
Pyrrolizidine alkaloids
Alkaloids derived from lysine
Piperidine alkaloids
Quinolizidine alkaloids
Indolizidine alkaloids
Alkaloids derived from nicotinic acid
Pyridine alkaloids
Alkaloids derived from tyrosine
Phenylethylamines and simple tetrahydroisoquinoline alkaloids
Modified benzyltetrahydroisoquinoline alkaloids
Phenethylisoquinoline alkaloids
Terpenoid tetrahydroisoquinoline alkaloids
Amaryllidaceae alkaloids
Alkaloids derived from tryptophan
Simple indole alkaloids
Simple β-carboline alkaloids
Terpenoid indole alkaloids
Quinoline alkaloids
Pyrroloindole alkaloids
Ergot alkaloids
Alkaloids derived from anthranilic acid
Quinazoline alkaloids
Quinoline and acridine alkaloids
Alkaloids derived from histidine
Imidazole alkaloids
Alkaloids derived by amination reactions
Acetate-derived alkaloids
Phenylalanine-derived alkaloids
Terpenoid alkaloids
Steroidal alkaloids
Purine alkaloids
Caffeine
Saxitoxin and tetrodotoxin
Further reading
7 Peptides, proteins, and other amino acid derivatives
Peptides and proteins
Ribosomal peptide biosynthesis
Peptide hormones
Thyroid hormones
Hypothalamic hormones
Anterior pituitary hormones
Posterior pituitary hormones
Pancreatic hormones
Interferons
Opioid peptides
Ribosomal peptide toxins
Enzymes
Non-ribosomal peptide biosynthesis
Modified peptides: penicillins, cephalosporins, and other ß-lactams
Penicillins
Cephalosporins
Other β-lactams
Cyanogenic glycosides
Glucosinolates
Cysteine sulfoxides
Further reading
8 Carbohydrates
Monosaccharides
Oligosaccharides
Polysaccharides
Aminosugars and aminoglycosides
Further reading

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