Magic Bullets to Conquer Malaria From Quinine to Qinghaosu 1st Edition by Irwin W Sherman ISBN 9781683670995

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ISBN 10: 
ISBN 13: 9781683670995
Author: Irwin W Sherman

“A clear, concise discourse of 300 years of malarial drug research.

• Presents a historical overview of antimalarial medicines and examines future challenges in the discovery and development of effective treatments and control strategies.
• Provides new perspectives on the creative process of drug discovery and the challenges of overcoming drug resistance.
• Discusses the use of larvicides, bednets, and DDT as well as recombinant DNA and monoclonal antibodies to block malaria transmission from mosquitoes to humans.
• Serves as a resource for microbiologists, parasitologists, pharmacologists, medicinal chemists, biochemists, physicians, and drug researchers.”

Magic Bullets to Conquer Malaria: From Quinine to Qinghaosu 1st Table of contents:

• Chapter One: The Ancient Origins of Malaria Treatment

  • The Discovery of Malaria: Early Observations and Theories
  • Traditional Remedies: Herbal Treatments in Ancient Civilizations
  • The Role of Quinine in Early Malaria Treatment
  • The First “Magic Bullet”: The Role of Peruvian Bark (Cinchona) in the 17th Century

• Chapter Two: Quinine – The First Breakthrough

  • The Isolation of Quinine: A Milestone in Malaria Treatment
  • The Rise of Quinine as the “Gold Standard”
  • Quinine’s Role in the Colonial Expansion of European Powers
  • Side Effects and Limitations of Quinine as a Treatment

• Chapter Three: The Search for Better Treatments

  • The Discovery of Synthetic Antimalarial Drugs
  • The Early 20th Century: New Hope from Chemotherapy
  • The Role of Sulfonamides and Other Early Drug Treatments
  • The Emergence of Drug Resistance and the Need for New Solutions

• Chapter Four: The Era of Chloroquine

  • The Discovery and Widespread Use of Chloroquine
  • Chloroquine as the “Magic Bullet” of the Mid-20th Century
  • The Successes and Challenges of Chloroquine in Malaria Control
  • The Rise of Chloroquine Resistance and the Search for Alternatives

• Chapter Five: Artemisinin and the Qinghaosu Revolution

  • The Origins of Qinghaosu: Traditional Use in Chinese Medicine
  • The Discovery and Isolation of Artemisinin
  • Artemisinin’s Role in Revolutionizing Malaria Treatment
  • The Mechanism of Action: How Artemisinin Targets the Malaria Parasite

• Chapter Six: Modern Treatments and Drug Combinations

  • Artemisinin-Based Combination Therapies (ACTs)
  • The Role of ACTs in Combating Malaria Resistance
  • Innovations in Drug Delivery: Slow-Release and Combination Pills
  • The Challenge of Maintaining Efficacy and Overcoming Resistance

• Chapter Seven: The Ongoing Battle Against Malaria

  • The Global Malaria Eradication Campaigns: Successes and Setbacks
  • Malaria in the 21st Century: Emerging Resistance and New Threats
  • The Role of Vaccine Development: RTS,S and Beyond
  • The Promise of Genomic Medicine and Innovative Drug Discovery

• Chapter Eight: Non-Pharmaceutical Approaches to Malaria Control

  • Insecticides and the Role of Vector Control
  • The Importance of Mosquito Nets and Environmental Measures
  • Malaria Education and Public Health Campaigns
  • The Role of International Organizations: WHO and Global Malaria Partnerships

• Chapter Nine: The Future of Malaria Treatment and Eradication

  • Advances in Gene Editing and Mosquito Control (e.g., CRISPR)
  • The Promise of a Malaria Vaccine: Current Research and Trials
  • Challenges to Global Malaria Eradication: Political, Economic, and Social Barriers
  • A Global Vision: Toward the End of Malaria by 2050

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