Introducing Genetics From Mendel to Molecules 2nd Edition by Alison Thomas ISBN 9781317417262 1317417267
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ISBN 10: 1317417267
ISBN 13: 9781317417262
Author: Alison Thomas
Introducing Genetics From Mendel to Molecules 2nd Edition Table of contents:
Chapter 1 Introduction
1.1 Key concepts in genetics
Chapter 2 Monohybrid Inheritance
2.1 Key principles of genetic inheritance
2.2 A genetic explanation of the monohybrid cross
2.3 Representing genetic crosses
2.4 A Punnett square
2.5 Mendel’s First Law of Segregation
2.6 Predicting the outcome of crosses
2.7 Chance and probability in genetics
2.8 The importance of large numbers
2.9 The test cross
Summary
Problems
Chapter 3 Extensions to Monohybrid Inheritance
3.1 Multiple allelism
3.2 Incomplete dominance
3.3 Representing crosses involving incomplete dominance
3.4 Explaining incomplete dominance
3.5 Redefining dominance relationships
3.6 Co-dominance
3.7 Lethal alleles
3.8 Are lethal alleles recessive or dominant?
3.9 Human pedigrees
3.10 The multiplication rule
Summary
Problems
Chapter 4 Dihybrid Inheritance
4.1 Two genes – two characters
4.2 Test cross
4.3 Two genes – one trait
4.4 Complementary genes
4.5 Epistasis
4.6 The chi-squared (χ2) test
Summary
Problems
Chapter 5 The Chromosomal Basis of Inheritance
5.1 The structure of chromosomes
5.2 The number of chromosomes
5.3 Homologous pairs of chromosomes
5.4 Diploid and haploid cells
5.5 Two types of nuclear division
5.6 Mitosis
5.7 The biological significance of mitosis
5.8 Meiosis
5.9 The biological significance of meiosis
5.10 Revisiting Mendel’s laws
Summary
Problems
Chapter 6 Sex Determination and Sex Linkage
6.1 Sex-determining chromosomes
6.2 Other sex-determining mechanisms
6.3 The Y chromosome and sex determination in humans
6.4 The expression of X-linked genes
6.5 Representing crosses involving X-linked genes
6.6 Sex-linked inheritance patterns
6.7 Pedigree analysis of human X-linked recessive inheritance
6.8 Human X-linked dominant inheritance
6.9 Inactivation of the X chromosome
6.10 Y-linked inheritance
Summary
Problems
Chapter 7 Linkage and Chromosome Mapping
7.1 Linkage and recombination
7.2 Representing dihybrid crosses involving linked genes
7.3 Explaining Morgan’s results
7.4 The use of the test cross inlink age studies
7.5 Producing chromosomal maps
7.6 Using a trihybrid test cross to map genes
7.7 Interference and coefficient of coincidence
7.8 A few comments on physical mapping
7.9 Mapping human genes
Summary
Problems
Chapter 8 Variation in Chromosomal Number and Structure
8.1 Changes in chromosome number: terminology
8.2 Aneuploidy
8.3 Monosomy
8.4 Trisomy
8.5 Polyploidy
8.6 Origins of polyploidy
8.7 Producing an autopolyploid
8.8 Producing an allopolyploid
8.9 Changes in chromosome structure
8.10 Changes in the arrangement of genes
8.11 Changes in the number of genes on a chromosome
8.12 Fluorescent in situ hybridization
Summary
Problems
Chapter 9 The Principles of Quantitative Genetics
9.1 Multifactorial traits: some definitions
9.2 Representing multifactorial traits
9.3 Calculating the mean
9.4 Calculating the variance
9.5 Calculating the standard deviation
9.6 Genes or environment
9.7 Partitioning phenotypic variance
9.8 Heritability index
9.9 Partitioning genetic varianceVp = Vg + Ve
9.10 Narrow-sense heritability
9.11 Investigating multifactorial traits in humans
Summary
Problems
Chapter 10 An Introduction to Population Genetics
10.1 Population genetics: some definitions
10.2 Calculating allele frequencies
10.3 The Hardy–Weinberg law
10.4 Calculating genotype frequencies
10.5 Testing for equilibrium
10.6 Disturbances of the Hardy–Weinberg equilibrium
10.7 Mutation
10.8 Migration
10.9 Genetic drift: random changes in small populations
10.10 Selection
Summary
Problems
Chapter 11 Heredity at the Molecular Level
11.1 The structure of DNA –a summary
11.2 The biochemical nature of nucleotides
11.3 The double helix
11.4 DNA packaging
11.5 Replicating DNA
11.6 Details of DNA replication
Summary
Problems
Chapter 12 From Genes to Proteins
12.1 Information flow from gene to protein – a summary
12.2 The biochemical nature of RNA
12.3 Producing RNA: transcription
12.4 The different forms of RNA
12.5 Exons and introns
12.6 The genetic code
12.7 Producing the protein: translation
12.8 The causes and consequences of mutation
Summary
Problems
Chapter 13 Manipulating DNA
13.1 An overview of recombinant DNA technology
13.2 Restriction enzymes
13.3 Vectors
13.4 Creating a recombinant DNA molecule
13.5 Introducing the recombinant DNA molecule into a host cell
13.6 The production of human recombinant proteins
13.7 The production of transgenic crops
13.8 The polymerase chain reaction
13.9 DNA sequencing
Summary
Problems
Solutions to Problems
Appendix
Glossary
Further Reading
Index
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