Injectable Dispersed Systems Formulation Processing and Performance 1st Edition by Diane Burgess ISBN 0367392828 9780367392826

SECTION I: BASIC PRINCIPLES

1: Physical Stability of Dispersed Systems

2: Biopharmaceutical Principles of Injectable Dispersed Systems

3: Characterization and Analysis of Dispersed Systems

4: In Vitro/In Vivo Release from Injectable Dispersed Systems

5: In Vitro/In Vivo Correlation for Modified Release Injectable Drug-Delivery Systems

SECTION II: DOSAGE FORMS

6: Coarse Suspensions: Design and Manufacturing

7: Emulsions: Design and Manufacturing

8: Liposomes: Design and Manufacturing

9: Microspheres: Design and Manufacturing

SECTION III: CASE STUDIES

10: Case Study: Development and Scale-Up of NanoCrystal® Particles

11: Case Study: Formulation Development and Scale-Up Production of an Injectable Perfluorocarbon Emulsion

12: Case Study: A Lipid Emulsion—Sterilization

13: Case Study: Formulation of an Intravenous Fat Emulsion

14: Case Study: DOXIL, the Development of Pegylated Liposomal Doxorubicin

15: Case Study: AmBisome—A Developmental Case Study of a Liposomal Formulation of the Antifungal Agent Amphotericin B

16: Case Study: Optimization of a Liposomal Formulation with Respect to Tissue Damage

17: Case Study: In Vitro/In Vivo Release from Injectable Microspheres

18: Case Study: Biodegradable Microspheres for the Sustained Release of Proteins

SECTION IV: QUALITY ASSURANCE AND REGULATION

19: Injectable Dispersed Systems: Quality and Regulatory Considerations

20: Regulatory Considerations for Controlled Release Parenteral Drug Products: Liposomes and Micro