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Herpesviridae Viral Structure Life Cycle and Infections 1st Edition by Toma R Gluckman ISBN 1608769216 9781608769216

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Author(s): Toma R. Gluckman
ISBN(s): 9781608769216, 1608769216
Edition: 1
File Details: PDF, 3.37 MB
Year: 2009
Language: english
SKU: EB-51355828 Category: Tag:

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ISBN 10: 1608769216 
ISBN 13: 9781608769216
Author: Toma R Gluckman

The Herpesviridae are a large family of DNA viruses that cause diseases in animals, including humans. The members of this family are also known as herpesviruses. Members of the herpesviridae family include oral and genital herpes, chickenpox, Kaposis sarcoma herpesvirus (most often seen in people with HIV), and the Epstein-Barr virus (which causes infectious mononucleosis). There are eight known herpesviruses out of 100 known herpesviruses that infect humans. Herpesviruses are currently being researched for use in medical treatment, especially in the areas of gene therapy and oncology. Research is also being done into interactions between viral and host proteins, the mechanisms involved in gene regulation, and to find out how herpesviruses establish, maintain, and reactivate latency. The herpesviruses vary greatly in genomic sequence and proteins synthesised, but they all share similar genome and virion structures. This book presents the latest research from around the world in this field.

Herpesviridae Viral Structure Life Cycle and Infections 1st Table of contents:

Part I Overview of the Herpesviridae Family

  1. introduction to herpesviruses
     1.1 historical background
     1.2 taxonomy and classification
     1.3 defining characteristics of the herpesviridae

  2. viral morphology and genome organization
     2.1 capsid structure
     2.2 tegument composition
     2.3 envelope glycoproteins
     2.4 genomic architecture and gene regulation

  3. molecular evolution and phylogeny
     3.1 co-evolution with vertebrate hosts
     3.2 genomic diversity among herpesviruses
     3.3 molecular epidemiology

Part II Viral Life Cycle and Replication
4. attachment and entry mechanisms
 4.1 receptor recognition and binding
 4.2 membrane fusion and entry pathways
 4.3 host cell specificity
5. viral gene expression and genome replication
 5.1 immediate-early, early, and late gene regulation
 5.2 mechanisms of DNA replication
 5.3 role of viral and host polymerases
6. assembly, maturation, and egress
 6.1 capsid formation and nuclear egress
 6.2 envelopment and tegument acquisition
 6.3 release from host cells
7. latency and reactivation
 7.1 establishment of latency
 7.2 maintenance of latent infection
 7.3 molecular triggers of reactivation

Part III Host–Virus Interactions and Immune Evasion
8. innate immune responses to herpesviruses
 8.1 pattern recognition receptors
 8.2 interferon signaling and antiviral states
 8.3 viral countermeasures
9. adaptive immunity and viral persistence
 9.1 T-cell and B-cell responses
 9.2 immune evasion mechanisms
 9.3 latency and immune modulation
10. pathogenesis and host cell transformation
 10.1 viral modulation of apoptosis
 10.2 oncogenic herpesviruses
 10.3 chronic infection and tissue pathology

Part IV Human Herpesviruses: Individual Members
11. herpes simplex viruses (HSV-1 and HSV-2)
 11.1 epidemiology and transmission
 11.2 clinical manifestations
 11.3 antiviral therapies
12. varicella-zoster virus (VZV)
 12.1 primary infection: chickenpox
 12.2 reactivation: shingles
 12.3 vaccination strategies
13. epstein–barr virus (EBV)
 13.1 infectious mononucleosis
 13.2 EBV-associated malignancies
 13.3 immune modulation
14. cytomegalovirus (CMV)
 14.1 congenital and opportunistic infections
 14.2 viral persistence and immune evasion
 14.3 antiviral resistance
15. human herpesvirus 6 and 7 (HHV-6/HHV-7)
 15.1 roseoloviruses and neurotropism
 15.2 chromosomally integrated HHV-6
16. kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8)
 16.1 KSHV pathogenesis
 16.2 latent and lytic programs
 16.3 KSHV-associated cancers

Part V Diagnosis, Treatment, and Control
17. laboratory diagnosis of herpesvirus infections
 17.1 molecular and serological methods
 17.2 culture and antigen detection
18. antiviral therapies and resistance mechanisms
 18.1 nucleoside analogs
 18.2 helicase-primase inhibitors
 18.3 novel antiviral strategies
19. vaccines and preventive measures
 19.1 live attenuated and subunit vaccines
 19.2 vaccine challenges and future perspectives

Part VI Emerging Topics and Future Directions
20. herpesviruses in animal models
 20.1 veterinary herpesviruses
 20.2 cross-species transmission
21. novel molecular techniques in herpesvirus research
 21.1 CRISPR and reverse genetics
 21.2 single-cell and omics approaches
22. global health implications and future challenges
 22.1 reactivation in immunocompromised hosts
 22.2 potential for therapeutic eradication

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