Handbook on the Toxicology of Metals 4th Edition by Gunnar F Nordberg ISBN 0444594531 9780444594532

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ISBN 10: 0444594531 
ISBN 13: 9780444594532
Author: Gunnar F Nordberg

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more.

Volume I covers “General Considerations” and Volume II is devoted to “Specific Metals.” A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.

Handbook on the Toxicology of Metals 4th Table of contents:

Volume I – General Considerations

1. Toxicology of Metals: Concepts & Trends

   • Global burden, historical perspective, poisoning, exposure, risk assessment.

2. Chemistry, Sampling, Analytical Methods & Speciation

   • Metal definitions, periodic table, compounds, solubility, metallomics, sampling, separation, detection, QA/QC.

3. Routes of Exposure, Dose & Toxicokinetics

   • Absorption, transport, metabolism, excretion, toxicokinetic models.

4. Metal & Metal Oxide Nanoparticles

   • Characterization, toxicity testing, individual nanoparticle types (gold, silver, platinum, etc.).

5. Metals from Implanted Devices – Toxicological issues & challenges.

6. Toxic Metals in Food – Cadmium, lead, mercury, arsenic, contamination sources.

7. Exposure Assessment & Dosimetry – PBPK modeling, biomonitoring.

8. Biological Monitoring & Biomarkers – QA, reference materials, exposure & effect biomarkers.

9. Molecular Mechanisms of Metal Toxicity & Carcinogenicity – Metal binding, genotoxicity, epigenetics.

10. Dose-Effect & Dose-Response Relationships – Modeling, species extrapolation, risk assessment.

11. Interactions & Mixtures – Combined effects, age/gender/drug influences.

12. Gene-Environment Interactions – Specific metals.

13. Epidemiological Approaches – Study design, exposure & effect assessment.

14. Essential Metals: Deficiency & Toxicity – Risk assessment principles.

15. Neurotoxicology – CNS development, mechanisms of neurotoxicity.

16. Cardiovascular Effects – Metal-specific effects.

17. Renal Effects – Kidney function & metal toxicity.

18. Carcinogenicity of Metals – Principal metals, mechanisms, epigenetic effects.

19. Immunotoxicology – Immunosuppression, hypersensitivity, autoimmunity.

20. Reproductive & Developmental Effects – Mechanisms, endocrine disruption.

21. Ecotoxicology – Sources, transport, accumulation, ecosystem effects.

22. Risk Assessment – Hazard identification, dose-response, risk characterization, management.

23. Diagnosis & Treatment of Metal Poisoning

24. Prevention Principles – Work and environmental safety.

25. Developing Countries – Exposure sources, public health, remediation.

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Tags: Gunnar F Nordberg, Toxicology, Metals