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Glia and Inflammation in Neurodegenerative Disease 1st Edition by MA Yenari, RG Giffard ISBN 1616688742 9781616688745

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Glia and Inflammation in Neurodegenerative Disease 1st Edition M.A. Yenari Digital Instant Download

Author(s): M.A. Yenari; R.G. Giffard
ISBN(s): 9781616688745, 1616688742
Edition: 1
File Details: PDF, 5.83 MB
Year: 2006
Language: english
SKU: EB-51369784 Category: Tags: ,

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ISBN 10: 1616688742 
ISBN 13: 9781616688745
Author: MA Yenari, RG Giffard

The brain has long been considered an immune privileged organ, meaning that inflammatory cells are excluded due to a relatively impenetrable blood brain barrier (BBB). However, this is not to say that the central nervous system is incapable of eliciting immune responses, as resident inflammatory cells exist within the brain parenchyma. Microglia have long been thought to be the brain’s resident immune cell with myeloid lineage similar to monocytes and macrophages. In this volume, the authors review the current state of knowledge with regard to immune responses and cell-cell interactions as they pertain to a variety of neurodegenerative diseases. The changing role of inflammation with development is considered. They also present a summary of the various therapeutic strategies employed both in the laboratory and at the clinical level.

Glia and Inflammation in Neurodegenerative Disease 1st Table of contents:

  • Chapter 1: Glial Cells: Types and Functions

    • Astrocytes: Their Role in Homeostasis and Neuroinflammation

    • Microglia: The Immune Cells of the Brain

    • Oligodendrocytes: Support and Myelination

    • Glial Cell Interactions and Their Impact on Neuronal Health

  • Chapter 2: The Inflammatory Response in the Brain

    • Mechanisms of Neuroinflammation

    • Acute vs. Chronic Inflammation in Neurodegeneration

    • Cytokines, Chemokines, and Inflammatory Mediators

    • The Blood-Brain Barrier and Immune Activation

  • Chapter 3: Glial Cells in Alzheimer’s Disease

    • The Role of Glia in the Pathogenesis of Alzheimer’s Disease

    • Microglial Activation and Amyloid Plaques

    • Astrocytic Dysfunction in Alzheimer’s Disease

    • Targeting Glia for Therapeutic Strategies in Alzheimer’s Disease

  • Chapter 4: Glia and Inflammation in Parkinson’s Disease

    • The Role of Microglia and Astrocytes in Parkinson’s Disease

    • Inflammation as a Driving Force of Dopaminergic Neuron Loss

    • Glial Responses to α-Synuclein Aggregation

    • Therapeutic Potential of Targeting Glia in Parkinson’s Disease

  • Chapter 5: Glia in Amyotrophic Lateral Sclerosis (ALS)

    • Glial-Mediated Inflammation in ALS Pathogenesis

    • The Role of Microglia and Astrocytes in ALS Motor Neuron Degeneration

    • Genetic Factors and Glial Dysfunction in ALS

    • Investigating Therapeutic Approaches Targeting Glia in ALS

  • Chapter 6: Glia and Multiple Sclerosis: An Inflammatory Perspective

    • The Role of Glial Cells in Multiple Sclerosis (MS)

    • Microglial Activation and Demyelination

    • Astrocytes in the Formation of Glial Scar Tissue

    • Targeting Glial-Mediated Inflammation in MS Therapy

  • Chapter 7: Glia and Inflammation in Huntington’s Disease

    • The Role of Glial Cells in Huntington’s Disease Pathogenesis

    • Inflammatory Mediators and Their Effects on Neuronal Survival

    • Targeting Glia in Huntington’s Disease: Current and Emerging Therapies

    • The Interplay Between Glial Cells and Huntingtin Protein Aggregates

  • Chapter 8: Glial Involvement in Prion Diseases

    • Prion Protein and Its Effects on Glial Function

    • Neuroinflammation in Prion Disease Pathogenesis

    • Microglial Activation in Prion Diseases: The Role of the Immune System

    • Potential Therapeutic Strategies Targeting Glia in Prion Diseases

  • Chapter 9: Glia in Traumatic Brain Injury and Neurodegeneration

    • The Role of Glial Cells Following Brain Injury

    • Acute vs. Chronic Inflammation in TBI

    • Glial Responses to Neuronal Injury and Neurodegeneration

    • Developing Therapeutic Interventions Targeting Glia After Brain Injury

  • Chapter 10: Modulating Glial Responses for Therapeutic Purposes

    • Approaches to Modulate Glial Activity in Neurodegenerative Disease

    • Immunomodulation and Inflammatory Pathways

    • Pharmacological Interventions Targeting Glial Cells

    • The Future of Glial-Based Therapeutics in Neurodegenerative Diseases

  • Chapter 11: Glial Cells as Biomarkers in Neurodegenerative Diseases

    • The Potential for Glial Cell Markers in Early Diagnosis

    • Blood and Cerebrospinal Fluid Biomarkers of Glial Activation

    • Imaging Techniques to Study Glial Cells in vivo

    • Clinical Implications of Glial Biomarkers in Disease Progression

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Tags: MA Yenari, RG Giffard, Glia, Inflammation, Neurodegenerative Disease