Genome Duplication 1st edition by Melvin DePamphilis, Stephen D Bell ISBN 978-0415442060

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ISBN 13: 978-0415442060

Author: Melvin DePamphilis, Stephen D. Bell

Genome Duplication provides a comprehensive and readable overview of the underlying principles that govern genome duplication in all forms of life, from the simplest cell to the most complex multicellular organism.

Using examples from the three domains of life – bacteria, archaea, and eukarya – Genome Duplication shows how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it: semi-conservative DNA replication by the replication fork. The text shows how the replication fork determines where organisms begin genome duplication, how they produce a complete copy of their genome each time a cell divides, and how they link genome duplication to cell division.

Genome Duplication explains how mistakes in genome duplication are associated with genetic disorders and cancer, and how understanding genome duplication, its regulation, and how the mechanisms differ between different forms of life, is critical to the understanding and treatment of human disease.

Table of contents: 

1. Genomes 
2. Three Domains of Life 
3. Replication Forks 
4. Replication Proteins: Leading-Strand Synthesis 
5. Replication Proteins: Lagging-Strand Synthesis 
6. Termination 
7. Chromatin Assembly, Cohesion, and Modification 
8. Replicons 
9. Replication Origins 
10. Origin Paradigms 
11. Initiation 
12. Cell Cycles 
13. Checkpoints 
14. Human Disease 
15. Evolution of Cellular Replication Machines

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Genome Duplication 1st edition

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Melvin DePamphilis,Stephen D Bell,Genome,Duplication