Genetics of Apoptosis 1st Edition by Stefan Grimm ISBN 1135325030 9781859960646

Genetics of Apoptosis 1st Edition by Stefan Grimm – Ebook PDF Instant Download/Delivery: 1135325030, 9781859960646
Full download Genetics of Apoptosis 1st Edition after payment

Product details:

ISBN 10: 1135325030 
ISBN 13: 9781859960646
Author: Stefan Grimm

Genetics of Apoptosis 1st Table of contents:

Section I: Molecular Biology of Apoptosis
Chapter 1. Death receptors in apoptosis
1. Introduction
2. Death receptors and ligands
3. Induction of apoptosis by death receptors
3.1 The molecular machinery of cell death – caspases
3.2 Activation of caspases by death receptors
4. Regulation of death receptor-induced apoptosis
4.1 Expression of death and decoy receptors
4.2 Inhibition of DD signaling by silencer of death domains (SODD)
4.3 Regulation of caspase-8 by FLICE-inhibitory proteins (FLIPs)
4.4 Regulation of BID cleavage and function
4.5 lnhibitor-of-apoptosis protein (lAPs) – sequestration of Smac/DIABLO and inhibition of caspases
4.6 NF-kB – a master regulator of death receptor-induced apoptosis
4.7 The dynamic balance between death receptors and apoptosis inhibitors – a tug-of-war that determi
5. Role of death receptor-induced apoptosis in the immune system
5.1 Regulation of the immune response
5.2 Disorders of the immune system resulting from deregulation of death receptor-induced apoptosis
6. Role of death receptor-induced apoptosis in development
7. Death receptor-induced apoptosis of tumor cells
7.1 Role of death receptors/ligands in tumor surveillance
7.2 Involvement of death receptors in response of tumor cells to anticancer therapy
7.3 Targeting death receptors for treatment of cancers
8. Conclusion
Acknowledgments
Chapter 2. The role off caspases in apoptosis
1. What are caspases?
2. Types of caspases
3. Caspase structure
4. Substrate specificity of caspases
5. Caspase activation
5.1 Caspase activation by oligomerization
5.2 Activation of caspase-8
5.3 The Apaf-1/caspase-9 apoptosome
5.4 Other mechanisms
6. Regulation of caspase activation
6:1 Regulation of caspase-8 activation by FLIPs
6.2 Regulation of caspases by IAPs
6.3 Regulation by Bcl-2 family
6.4 Regulation by transcription
7. Caspase targets
8. Function of individual caspases
8.1 Caspase mutations and gene knockouts
8.2 Knockout of the caspase adaptors
Chapter 3. Making sense of the Bcl-2 family of apoptosis regulators
1. Introduction
2. Internecine warfare or private agendas
2.1 Rheostat model of dimerization
2.2 BH3 domains
2.3 Mouse genetic models
2.3 Proapoptotic functions: yeast models
2.4 Proapoptotic functions: membrane permeability
2.5 Proapoptotic functions: permeability transition pores
2.6 Proapoptotic functions: homooligomers and pores
2.7 Proapoptotic functions: different designs
2.8 Antiapoptotic functions: membrane permeability
2.9 Antiapoptotic functions: what color is your parachute?
2.10 Bcl-2 and Bax: identical twins?
3. Location, location, location
3.1 Endoplasmic reticulum targeting
3.2 Sequestration at non-mitochondrial sites
4. A finger in every pot
5. Specialists or generalists?
6. Summary
Chapter 4. Functional domains in apoptosis proteins
1. Introduction
1.1 The domain concept
1.2 Domain detection methods
1.3 Functional domains in apoptosis
2. Death ligands and receptors
2.1 The TNF family
2.2 The TNFR family
3. Adapter domains
3.1 The death domain (DD)
3.2 The death effector domain (DED)
3.3 The caspase recruitment domain (CARD)
3.4 The pyrin domain (PYD)
3.5 The Toll/IL-IR domain (TIR)
4. Caspases and inhibitors
4.1 The caspase catalytic domain
4.2 The BIR domain
5. Other important domains
5.1 The Bcl-2 motif family
5.2 The NB-ARC and NACHT NTPase domains
6. A domain-centric view of apoptosis
Section II: Cell Biology of Apoptosis
5. The role of the endoplasmic reticulum in apoptosis
1. Introduction
2. ER stress-induced apoptosis
2.1 The unfolded protein response
2. 2 ER stress-induced apoptotic signal transduction pathways
2.3 CHOP/GADD153
2.4 Caspase-12
2.5 JNK
2.6 c-Abl
2.7 BAX, BAK, and BH3-only molecules
3. Regulation of mitochondrial apoptosis by ER Ca2+ signals
3.1 ER Ca2+ release
3.2 Ca2+ signaling between the ER and mitochondria
3.3 Regulation of mitochondrial permeability transition by ER Ca2+ spikes during apoptosis
3.4 Coordination of Cyt.c release by ER-derived Ca2+ waves
3.5 Bcl-2 family members regulate ER Ca2+ homeostasis
4. Other ER regulators of apoptosis
4.1 BAP31
4.2 BIK
4.3 The reticulon family
4.4 Presenilins
5. Concluding remarks
Chapter 6. Mitochondria in apoptosis induction
1. Introduction
2. The mitochondria
3. Apoptosis pathways
4. The Bcl-2 protein family
5. Structure and channel-forming activity
6. Activation of the multidomain Bcl-2 proteins
7. BH3-domain-only’ proteins as multidomain protein activators
8. How do the multidomain Bcl-2 proteins trigger the release of proteins from the intermembrane spac
8.1 Release mechanisms
8.2 Bax channels
8.3 Bax-VDAC channels
8.4 Bax-ANT channels
8.5 The permeability transition pore
9. Activities of the mitochondrial proteins released
10. Bax and mitochondrial respiration
11. Conclusion
Section III: Cell Death in Model Systems
Chapter 7. Regulators and applications of yeast apoptosis
1. Introduction
2. Expression of metazoan apoptotic genes induces cell death in yeast
3. Mutations leading to apoptosis in yeast
4. ROS are central regulators of yeast apoptosis
5. DNA damage induces yeast apoptosis
6. Speculations about the origin of apoptosis
7. Apoptosis and aging in yeast
8. Applications of yeast apoptosis to plant research
9. Applications of yeast apoptosis for medical research
10. Perspectives
Chapter 8. Evolution of cell death: caspase-mediated mechanisms in early metazoans; noncaspase mecha
1. Introduction
2. Cell death in Cnidaria and Porifera
2.1 Apoptosis in Hydra regulates cell numbers
2.2 Apoptosis during gamete development in Hydra
2.3 Apoptosis during metamorphosis in Hydractinia
2.4 Programmed cell death in Porifera
3. Cell death in single-celled eukaryotes
3.1 Differentiation and cell death in D. discoideum
3.2 Programmed cell death in Tetrahymena
3.3 Programmed cell death in Trypanosoma
4. Conclusions
Acknowledgments
Chapter 9. Programmed cell death in C. elegans
1. Introduction
2. Identity and origin of cells undergoing programmed cell death during the somatic development of C
3. Identity and origin of cells undergoing programmed cell death in the C. elegans germ line
4. Identification and quantification of programmed cell death in C. elegans
5. Mutants define four distinct steps in the core apoptotic pathway
6. Four genes, egl-1, ced-3, ced-4, and ced-9, define a genetic pathway needed for (almost) all prog
7. egl-1, ced-3, ced-4, and ced-9 are functionally conserved throughout evolution
8. EGL-1, CED-3, CED-4, and CED-9 are part of a molecular framework regulating programmed cell death
9. Modulators and downstream components of the cell-death pathway
10. The regulation of programmed cell death in specific cell types
11. Germ-line cell death
12. Genes required for the engulfment of dying cells
13. Potential functions of programmed cell death in C. elegans
14. Conclusion
Acknowledgments
Chapter 10. Apoptosis in Drosophila
1. Introduction
2. Genetic screens uncover genes important in developmental apoptosis
3. How Rpr, Hid, Grim, and Ski initiate apoptosis
4. Caspases are required for Rpr-, Grim-, Hid-, and Ski-induced apoptosis
5. Modifiers of caspase activation: the mitochondrial pathway
6. How is the mitochondrial pathway activated?
7. Moving upstream: regulation of Rpr, Hid, Grim, and Ski activity
8. What is the role of apoptosis in Drosophila development?
9. Conclusions
Chapter 11. Cell-culture systems in apoptosis
1. Introduction: advantages of cell culture to investigate apoptosis
2. Cell-culture approaches to isolate genes in apoptosis
2.1 Correlative strategy
2.2 Selection strategies
2.3 Screening strategy
3. Conclusions
Chapter 12. Caspase-independent cell death
1. Introduction
2. Four patterns of death: from apoptosis to necrosis
3. Death programs beyond caspases
4. Signaling in caspase-independent PCD
4.1 Noncaspase proteases as mediators of PCD
4.2 Death receptors as triggers of alternative PCD
4.3 Mitochondrial control of caspase-independent PCD
5. The significance of the program: removal of corpses
6. Complex control of tumor cell death
6.1 Alternative death pathways in cancer
6.2 Designing new therapies based on alternative PCD pathways
7. Alternative cell death in the nervous system
8. Evolution of cell-death principles
9. Conclusion

People also search for Genetics of Apoptosis 1st:

    
genes of apoptosis
    
x-linked inhibitor of apoptosis (xiap) deficiency
    
3 steps of apoptosis
    
what are the four stages of apoptosis
    
4 types of cell death

Tags:

Stefan Grimm,Genetics,Apoptosis