Genetic Analysis of Complex Diseases 2nd Edition by Jonathan L Haines, Margaret A Pericak Vance ISBN 0471781142 9780471781141

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ISBN 10: 0471781142 
ISBN 13: 9780471781141
Author: Jonathan L Haines, Margaret A Pericak Vance

The book A History of the Kennedy Space Center by Kenneth Lipartito and Orville R. Butler offers a comprehensive examination of NASA’s iconic launch facility, detailing its evolution from the early days of space exploration to the era of the Space Shuttle and beyond. While the full table of contents is not publicly available, the book’s structure is outlined as follows:

Genetic Analysis of Complex Diseases 2nd Table of contents:

1 Designing a Study for Identifying Genes in Complex Traits
Introduction
Components of a Disease Gene Discovery Study
Keys to a Successful Study
References
2 Basic Concepts in Genetics
Introduction
Historical Contributions
DNA, Genes, and Chromosomes
Genes, Mitosis, and Meiosis
Inheritance Patterns in Mendelian Disease
Genetic Changes Associated with Disease/ Trait Phenotypes
Susceptibility Versus Causative Genes
Summary
References
3 Determining the Genetic Component of a Disease
Introduction
Study Design
Approaches to Determining the Genetic Component of a Disease
Summary
References
4 Study Design for Genetic Studies
Introduction
Selecting a Study Population
Family‐Based Studies (Linkage)
Family‐Based Studies (Association)
Cohort Studies
Cross‐Sectional Studies
Case–Control Studies
Other Study Designs
Biobanks
Other Biobanks
Biospecimens for Biobanks
Summary
References
5 Responsible Conduct of Research in Genetic Studies
Introduction
Research Regulations and Genetics Research
Addressing Pertinent ELSI in Genetic Research
Practical Methods for Efficient High‐Quality Genetic Research Services
References
6 Linkage Analysis
Disease Gene Discovery
Ability to Detect Linkage
Real World Example of LOD Score Calculation and Interpretation
Disease Gene Localization
Multipoint Analysis
Effects of Misspecified Model Parameters in LOD Score Analysis
Impact of Incorrect Disease Allele Frequency
Impact of Incorrect Mode of Inheritance
Impact of Incorrect Disease Penetrance
Impact of Incorrect Marker Allele Frequency
Control of Scoring Errors
Genetic Heterogeneity
Practical Approach for Model‐Based Linkage Analysis of Complex Traits
Nonparametric Linkage Analysis
Identity by State and Identity by Descent
Methods for Nonparametric Linkage Analysis
Tests for Linkage Using Affected Sibling Pairs (ASP)
Tests Based on Identity by Descent in ASPs
Multipoint Affected Sib‐Pair Methods
Methods Incorporating Affected Relative Pairs
NPL Analysis
Fitting Population Parameters
Power Analysis and Experimental Design Considerations for Qualitative Traits
Examples of Sib‐Pair Methods for Mapping Complex Traits
Mapping Quantitative Traits
Measuring Genetic Effects in Quantitative Traits
Study Design for Quantitative Trait Linkage Analysis
Variance Components Linkage Analysis
Nonparametric Methods
The Future
References
7 Data Management
Developing a Data Organization Strategy
Database Management System (DBMS) and Structured Query Language (SQL)
Database Implementation
Other Tools for Data Management and Manipulation
Conclusion
References
8 Linkage Disequilibrium and Association Analysis
Introduction
Linkage Disequilibrium
Summary
References
9 Genome‐Wide Association Studies
Introduction
Design
Data Analysis
Conclusion
References
10 Bioinformatics of Human Genetic Disease Studies
Introduction
Common Threads Genome Analysis
Processing and Analysis of Genomic Data
Bioinformatics Resources
References
11 Complex Genetic Interactions/Data Mining/Dimensionality Reduction
Human Diseases Are Complex
Complexity of Biological Systems
Statistical and Mathematical Concepts of Complex Genetic Models
Analytic Approaches to the Detection of Complex Interactions
Conclusion
References
12 Sample Size, Power, and Data Simulation
Introduction
Sample Size and Power
Power Calculations and Simulation
Power Studies for Association Analysis
Power Simulations for Linkage Analysis

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