Gene Environment Interactions in Psychiatry Nature Nurture Neuroscience 1st Edition by Bart Ellenbroek, Ji Un Youn ISBN 9780128017838 012801783X
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ISBN 10: 012801783X
ISBN 13: 9780128017838
Author: Bart Ellenbroek, Ji Un Youn
Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene–environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the most important psychiatric disorders in detail.
Each chapter has a similar structure that includes a general description of the disorder that is followed by an analysis of the role of genes and how they are affected by environmental factors. Each chapter ends with a description of the most relevant animal models, again focusing on gene–environment interactions.
The book concludes with a critical evaluation of the current research and an outlook for the (possible) future, offering a vignette into the fascinating world of nature, nurture, and neuroscience.
- Written to provide in-depth basic knowledge on gene–environment interactions for graduate students, postgraduate students, clinicians, and scientists
- Includes descriptions of the major psychiatric disorders
- Provides detailed descriptions of animal models and basic genetic information
- Presents well-illustrated color figures to explain complex features in a simple manner
Gene Environment Interactions in Psychiatry Nature Nurture Neuroscience 1st Edition Table of contents:
Section I: General introduction
Chapter 1: Introduction
Abstract
Introduction
Gregor Johann Mendel
Mendel’s first law of inheritance: the law of segregation
Mendel’s second law of inheritance: the law of independent assortment
The legacy of Mendel’s work
Criticism of Mendel’s work
The search for the Mendelian elements
The sex chromosomes
Beyond Mendel: the historical development of molecular genetics
A brief history of behavioral genetics
Chapter 2: The Genetic Basis of Behavior
Abstract
Introduction
The molecular structure of DNA
DNA synthesis and replication
The structure of the genome
DNA transcription
The structure of genes
mRNA processing
mRNA translation
Genetic alterations
Single Nucleotide Variations
Tandem repeat sequences
Triplet repeats
Variable Number Tandem Repeats (VNTRs)
Short insertions and deletions (indels)
Copy number variations (CNVs)
Chromosomal variations
Chapter 3: Animal Modelling in Psychiatry
Abstract
Introduction
Animal models
Validating animal models
Genetic modulation in animals
Chapter 4: The Environmental Basis of Behavior
Abstract
Introduction
Environmental factors
Timing
The prenatal period
The perinatal period
The postnatal period
The adolescent period
Evaluating the role of environmental factors in animals
Developmental differences between rodents and humans
Chapter 5: Environment Challenges and the Brain
Abstract
Introduction
Early environmental challenges and structural brain changes
Early environmental challenges and the immune system
Early environmental challenges and the hypothalamic pituitary adrenal (HPA) axis
Early environmental challenges and neurotransmitter changes
Early environmental challenges and epigenetic changes
The molecular structure of chromosomes
The histone family of proteins
Epigenetic mechanisms – introduction
Modification at the level of the nucleotides
Chemical modification at the level of the histones
Structural changes at the level of the nucleosome
Early environmental challenges and epigenetic changes
Section II: Gene-environment interactions in psychiatric disorders
Chapter 6: Drug Addiction
Abstract
Introduction
Diagnosis and symptoms
The epidemiology of drug addiction
The neurobiology of drug addiction
The pharmacological treatment of drug addiction
The aetiology of drug addiction
Animal models for drug addiction
Chapter 7: Affective Disorders
Abstract
Introduction
Major depressive disorder
Bipolar disorder (BP)
Chapter 8: Childhood Disorders
Abstract
Introduction
Attention deficit hyperactivity disorder
Autism spectrum disorders
Chapter 9: Schizophrenia
Abstract
Introduction
Diagnosis and symptoms
The epidemiology of schizophrenia
The neurobiology of schizophrenia
The pharmacological treatment of schizophrenia
The aetiology of schizophrenia
Animal models for schizophrenia
Chapter 10: Conclusions and the Road Ahead
Abstract
Introduction
The genetic revolution and psychiatry
The genetic analysis is incomplete
Genetic effects are moderated by the environment
Psychiatric disorders are heterogeneous
Looking toward the future
The future of animal modelling
Conclusion
Abbreviations
Index
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Bart Ellenbroek,Ji Un Youn,Gene Environment Interactions,Psychiatry,Nature,Nurture,Neuroscience