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Gene Delivery and Therapy for Neurological Disorders 1st Edition by Xuenong Bo ,Joost Verhaagen ISBN 1493953168 978-1493953165

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Gene Delivery and Therapy for Neurological Disorders 1st Edition Xuenong Bo Digital Instant Download

Author(s): Xuenong Bo, Joost Verhaagen (eds.)
ISBN(s): 9781493923052, 1493923056
Edition: 1
File Details: PDF, 7.97 MB
Year: 2015
Language: english
SKU: EB-4967612 Category: Tags: ,

Gene Delivery and Therapy for Neurological Disorders 1st Edition by Xuenong Bo ,Joost Verhaagen – Ebook PDF Instant Download/Delivery:1493953168 978-1493953165
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Product details: 

ISBN 10:1493953168 

ISBN 13:978-1493953165

Author:Xuenong Bo ,Joost Verhaagen 

This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors’ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson’s and Alzheimer’s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work.  Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab.

Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

Table of contents: 

1 Adeno-Associated Vectors for Gene Delivery to the Nervous System.
Pádraig J. Mulcahy, Christopher Binny, Bartosz Muszynski,Evangelia Karyka, and Mimoun Azzouz
2 Lentiviral Vectors for Gene Delivery to the Nervous System
Ioanna Eleftheriadou and Nicholas D. Mazarakis
3 Gene Therapy for Parkinson’s Disease: AAV5-Mediated Deliveryof Glial Cell Line-Derived Neurotrophic Factor (GDNF) 
Bas Blits, Deniz Kirik, Harald Petry, and Stephan Hermening
4 Gene Delivery and Gene Therapy for Alzheimer’s Disease
Maya Woodbury, Tomomi Kiyota, and Tsuneya Ikezu
5 Gene Therapy for Huntington’s Disease 
 Angela Wu, Dahna M. Fong, and Deborah Young
6 Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury
Xuenong Bo and Yi Zhang
7 Gene Delivery to Neurons of the Dorsal Root GangliaUsing Adeno-Associated Viral Vectors.
Nitish D. Fagoe, Ruben Eggers, Joost Verhaagen,and Matthew R. J. Mason
8 Targeted Gene Therapy for Ischemic Stroke
Fanxia Shen and Hua Su
9 Adeno-Associated Viral Gene Therapy for Retinal Disorders
Samantha R. de Silva, Michelle E. McClements, Mark W. Hankins,and Robert E. MacLaren
10 Gene Therapy for Epilepsies
En-Ju D. Lin and Matthew J. During
11 AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement
Diane Golebiowski, Allison M. Bradbury, Churl-Su Kwon,Imramsjah M. J. van der Bom, Lorelei Stoica, Aime K. Johnson,Diane U. Wilson, Heather L. Gray-Edwards, Judith A. Hudson, Jacob A. Johnson, Ashley N. Randle, Brian K. Whitlock, James L. Sartin, Anna Luisa Kühn, Matthew Gounis, Wael Asaad, Douglas R. Martin,and Miguel Sena-Esteves
12 Gene Therapy in Spinal Muscular Atrophy (SMA) ModelsUsing Intracerebroventricular Injection into Neonatal Mice .
Monir Shababi, Erkan Y. Osman, and Christian L. Lorson
13 Gene Therapy for Chronic Pain: How to Manipulateand Unravel Pain Control Circuits from the Brain? 
Isabel Martins and Isaura Tavares
14 Gene Therapy Approaches Using Reproducible and Fully PenetrantLentivirus-Mediated Endogenous Glioma Models
 John Lynes, Carl Koschmann, Mia Wibowo, Vandana Saxena,Marianela Candolfi, Mariela A. Moreno Ayala, Maria G. Castro,and Pedro R. Lowenstein

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Xuenong Bo,Joost Verhaagen,Gene,Delivery