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Functional Lipidomics 1st Edition by Li Feng, Glenn D Prestwich ISBN 1574444670 9781574444674

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Functional Lipidomics 1st Edition Li Feng Digital Instant Download

Author(s): Li Feng, Glenn D. Prestwich
ISBN(s): 9781574444674, 1574444670
Edition: 1
File Details: PDF, 7.92 MB
Year: 2005
Language: english
SKU: EB-2164034 Category: Tags: ,

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ISBN 10: 1574444670 
ISBN 13: 9781574444674
Author: Li Feng, Glenn D Prestwich

Lipids play an essential role in cell signaling and subcellular structure. Systematic analysis of the total lipid structure of a cell or organism, the lipodome, can reveal novel avenues of therapeutic intervention and diagnosis. This analysis is best modeled after the lessons learned from proteomics. With contributions from pioneering researchers from the US, Europe, Canada, Japan, and China, Functional Lipidomics introduces lipidomics, explores the current state of the field, and provides a comprehensive background for future groundbreaking work in this burgeoning field. The first book dedicated to the topic, Functional Lipidomics first defines and introduces the field before delving deeply into the methods, processes, analyses, and research aspects. The book uncovers the biosynthesis, metabolism, and function of fatty acids, acylglyerols, glycerophospholipids, sphingolipids, terpenes, and lipids that complex with proteins. Taking both academic and industrial perspectives, the contributors elaborate upon cutting-edge approaches to lipid analysis, diagnostic approaches using lipid and lipid-binding protein patterns, and the therapeutic significance of targeting proteins involved with the lipid signaling pathway. Functional Lipidomics elucidates state-of-the-art strategies and techniques that enable us to understand biochemical patterns related to disease states, develop new targets for drug design, and identify important markers of a developmental stage, pathological condition, or disease treatment.

Functional Lipidomics 1st Table of contents:

Chapter 1: The LIPID MAPS Approach to Lipidomics
Abstract
Introduction
Background and Broad Context
Significance for Biomedical Science and Disease
Focus Areas
Introduction to Lipidomics Focus Areas
Fatty Acids and Eicosanoids Core
Neutral Lipids Core
Glycophospholipids Core
Sphingolipids and Glycosphingolipids Core
Sterols Core
Isoprenoids and Structural Lipidomics Core
Summary and Cross Talk Among Lipid Classes
Acknowledgments

Chapter 2: LC/MS Methodology in Lipid Analysis and Structural Characterization of Novel Lipid Species
Part I: Introduction
Magnetic Sector and Electric Sector
Quadrupole Mass Filters and Ion Traps
Interface to High-Pressure Liquid Chromatography (HPLC)
ESI Mechanism
Molecular Ion Species
Collisional Activation of Lipid Ions
Data Systems
Part II: Electrospray Mass Spectra of Sample Lipids
Fatty Acids
Glycerolipids
Glycerophospholipids
Sphingolipids
Sterols
Isoprenoids
Saccharolipids
Polyketides
Conclusion
Acknowledgments
References

Chapter 3: Functional Plasticity of Lipid Mediators: The Example of Endocannabinoids
The “Functional Plasticity” Concept: an Introduction
Endocannabinoids and Their Best-Known Molecular Targets
Metabolism of Endocannabinoids
Metabolic Plasticity of Endocannabinoids
Anandamide: A Typical Example
Neurotransmitter-Gated Channels
Calcium Channels
Potassium Channels
TRPV1 Channels
Anandamide as an Intracellular Messenger
Peculiarities of Bioactive Lipids and Endocannabinoids
Acknowledgments
References

Chapter 4: Eicosanoid Lipidomics
Introduction
Eicosanoids
Pathways of Arachidonic Acid Metabolism
Cyclooxygenase Products
Lipoxygenase Products
Other Oxidative Metabolites
Pathways of Eicosanoid Metabolism
ω–Oxidation
β–Oxidation
Conjugation
Detection and Quantitation
Conclusion
Acknowledgment
Reference

Chapter 5: Functional Lipidomics: Lysophosphatidic Acid as a Target for Molecular Diagnosis and Therapy of Ovarian Cancer
Summary
Introduction
Physiologic Role of LPA
LPA Receptors
LPA Metabolism
Pathophysiology of LPA in Ovarian Cancer
LPA as a Therapeutic Target
Targeting LPA Function in Patients
Conclusions
References

Chapter 6: Analysis of Lysophospholipids in Human Body Fluids
Abstract
Introduction
Lipid Preparation from Biological Samples
Sample Selection
Sample Collection and Processing
Lipid Extraction
Lipid Separation
TLC, HPLC, Solid-Phase Extraction
Lipid Analyses
Comparison of Analysis Methods
Internal Standards
Quantitative Analyses
Future Perspective
Acknowledgments
Reference

Chapter 7: Functional Lipidomics: Lessons and Examples from the Sphingolipids
Introduction and Historical Perspective
Sphingolipid Structure and Function
Bioactive Lipid Networks
Functional Integration
Scope of Lipidomics
Compartmentalization and Transport
Acknowledgments
References

Chapter 8: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Analysis of Sphingolipids
Abstract
Introduction
Biosynthesis and Turnover
LC and MS
Materials and Methods
Results and Discussion
Quantitation
Chromatography Methods
Conclusions
Acknowledgments
References

Chapter 9: Methods of Probing Phosphoinositides–Protein Interactions
Introduction to Phosphoinositide Signaling
Probe Modification Strategies
Cellular Studies
Visualization and Assays
Protein–Lipid Interaction Techniques
Closing Remarks
References

Chapter 10: Fishing for Pharmaceutically Relevant Phosphoinositide-Binding Proteins Using Chemical Proteomics
Summary
PI3K Signaling and Proteomics
Functional Proteomics
Phosphoinositide–Protein Interactions
Chemical Proteomics Strategies
Outlook
Acknowledgments
References

Chapter 11: Phosphoinositide Profiling in Complex Lipid Mixtures
Abstract
Introduction
Analytical Challenges
PI Extraction and Analysis Methods
Receptor-Based Approaches
Mass Spectrometry
Activity Measurements
Conclusions and Outlook
Acknowledgments
Abbreviations
References

Chapter 12: Multiplexed Lipid Arrays of Anti-IgM–Induced Changes in Glycerophospholipid Composition
Abstract
Introduction
Results
Mathematical and MS Analysis
Lipid Arrays
Discussion
Methods
Acknowledgment
References

Chapter 13: Specific Lipid Alterations in Alzheimer’s Disease and Diabetes
Abstract
Introduction
ESI Intrasource Separation
Shotgun Lipidomics Applications
Sulfatide and Alzheimer’s
Diabetes-Induced Lipid Changes
Conclusion
Acknowledgment
References

Chapter 14: High-Throughput Lipid Profiling to Identify and Characterize Genes Involved in Lipid Metabolism, Signaling, and Stress Response
Introduction
Profiling Platforms and Processes
Quantification and Data Handling
Functional Gene Characterization
Examples from Plant and Disease Models
Perspectives

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Tags: Li Feng, Glenn D Prestwich, Functional Lipidomics