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From Biotechnology to Genomes The Meaning of the Double Helix 1st Edition by Philippe Goujon ISBN 9810243286 9789810243289

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Author(s): Philippe Goujon
ISBN(s): 9789810243289, 9810243286
Edition: 1st
File Details: PDF, 45.55 MB
Year: 2001
Language: english
SKU: EB-922434 Category: Tag:

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ISBN 10: 9810243286 
ISBN 13: 9789810243289
Author: Philippe Goujon

Aimed at scientists and non-specialised readers alike, this book retraces the source of national and international biotechnology programmes by examining the origins of biotechnology and its political and economic interpretation by large nations. With a foreword by André Goffeau, who initiated the European Yeast Genome Project, the book describes the achievements of the first genetic and physical maps, as well as the political and scientific genesis of the American Human Genome Project. Following these advances, the author discusses the European biotechnology strategy, the birth and implementation of European biotechnology programmes and the yeast genome project. After a detailed description of scientific policy and administrative, technical and scientific achievements, the principal stages of the yeast project and its major benefits are discussed. This enables the reader to obtain a panoramic view of this developing discipline at the dawn of the twenty-first century, as well as a better knowledge of the means deployed at international level. The conclusion gives a very detailed account of the genesis and early stages of this new scientific and technological field called genomics which appears to be a key component of modern industry. By using an epistemological analysis, the conclusion poses the problem of a new representation of life and critically appraises the limitations and deficiencies.

From Biotechnology to Genomes The Meaning of the Double Helix 1st Table of contents:

1 The Invention of Biotechnology
1.1 The Origins of Biotechnology
1.2 The Emergence of a New Concept of Life
1.3 From Zymotechnology to Biotechnology
1.4 The Engineering of Nature – Towards the Best of all Possible Worlds
1.5 Technique, Biology and the Development of Biotechnics
1.6 The Recognition of Biotechnology by the Institutions

2 Political Interpretations of Biotechnology and the Birth of the First Research Programs
2.1 The Example of the United States
2.2 Biotechnology in Japan: Economic Success and Ecological Failure
2.3 Germany and the Political Aspect of Biotechnology
2.4 The British Development of Biotechnology: Delayed Political Reaction
2.5 The French Reaction
2.6 The European Community and Biotechnology – The Emergence of the First European Biotechnology Program

3 The Foundations of the Heralded Revolution
3.1 From the Frontiers of Genetics to the Birth of Molecular Biology
3.2 The Secret of Life: DNA
3.3 The First Sequencing of a Protein: Insulin
3.4 Techniques of DNA Sequencing
3.5 Gene Money, or the Miracles Expected of Biotechnology
3.6 The Japanese Threat and the Human Frontier Science Program

4 Attack on the Genomes: The First Genetic and Physical Maps
4.1 The Problem of Gene Localization
4.2 Polymorphic Markers, Gene Mapping and the Great Gene Hunt
4.3 Towards a Complete Linkage Map
4.4 Physical Genome Mapping: The Reconstruction of a Complicated Puzzle
4.5 The First Physical Maps of Large Genomes
4.6 Towards a Physical Map of the Human Genome

5 The Human Genome Project and the International Sequencing Programs
5.1 The Ultimate Challenge: The Human Genome Project
5.2 The Department of Energy Initiative
5.3 The NIH Genome Project
5.4 HUGO, or the Difficulties of International Coordination
5.5 The Importance of Model Organisms
5.6 The International Dimensions of Genome Research: The First Stirrings in Other Countries

6 European Biotechnology Strategy and Sequencing the Yeast Genome
6.1 Towards a New European Research Policy for Biotechnology
6.2 The 1980s: An Implementation of the 1983 Strategy?
6.3 BAP’s First Year
6.4 The Revision of the BAP Program
6.5 The Origins and Nature of the Yeast Genome Sequencing Project
6.6 Critical Discussions and the Adoption of the Yeast Genome Sequencing Project

7 The Decryption of Life
7.1 The Structure and Organization of the European Yeast Genome Sequencing Network
7.2 A World First – The Sequence for a Whole Eucaryote Chromosome: Chromosome III of the Yeast Saccharomyces cerevisiae
7.3 The Complete Sequence of the Genome and the Intensification of European Efforts
7.4 After the Sequence – The Challenge of Functional Analysis
7.5 Sequences, Sequences and More Sequences
7.6 From Science to Economics

8 Conclusion: The Dreams of Reason or the New Biology’s Dangerous Liaisons
8.1 Fascination but Anxiety Concerning Progress in the Life Sciences
8.2 Reductionism vis-a-vis the Complexity of Life
8.3 From Science to Ideology – The Dangers of “The Genetic All”
8.4 The Health Excuse – A New Utopia?
8.5 Behind Gene Therapy – The Dangerous Liaisons of the New Biology
8.6 Convenient Reductionism
8.7 The Reasons Behind an Ideology

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Tags: Philippe Goujon, Biotechnology, Genomes, Double Helix